ASIP and MC5R

Number of citations: 0 (PubMedID 9058374)
Data Source: HPRD (in vitro)

		ASIP	MC5R
Name		agouti signaling protein	melanocortin 5 receptor
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Protein Binding Hormone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Epigenetic Regulation Of Gene Expression Melanin Biosynthetic Process Pigmentation Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Melanin Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		None	Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		None	Bremelanotide
GWAS		Blood protein levels ( 30072576 ) Breast cancer ( 22976474 ) Burning and freckling ( 18488028 ) Facial pigmentation ( 25705849 ) Freckles ( 18488028 ) Freckling ( 20585627 ) Hair color ( 20585627 ) Low tan response ( 29739929 ) Melanoma ( 21983787 28212542 ) Nevus count or cutaneous melanoma ( 30429480 ) Non-melanoma skin cancer ( 29739929 ) Red vs. non-red hair color ( 18488028 ) Skin colour saturation ( 25963972 ) Skin pigmentation ( 28300201 ) Skin sensitivity to sun ( 18488028 25963972 ) Tanning ( 23548203 ) Vitiligo ( 27723757 )	Depression in smokers ( 30219690 ) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334 ) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814 )
Interacting Genes		6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R	3 interacting genes: AGRP ASIP POMC
Entrez ID		434	4161
HPRD ID		02562	08965
Ensembl ID		ENSG00000101440	ENSG00000176136
Uniprot IDs		P42127	P33032
PDB IDs		1Y7J 1Y7K 2KZA 2L1J	8INR 8IOD
GO Terms Enriched among Interactors		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Feeding Behavior G Protein-coupled Receptor Signaling Pathway Regulation Of Behavior Hormone Binding Neuropeptide Binding Plasma Membrane Corticotropin Receptor Activity Homoiothermy Response To Melanocyte-stimulating Hormone Memory T Cell Extravasation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway T Cell Extravasation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Regulation Of Eating Behavior UV Protection Signal Transduction UV-damage Excision Repair Ubiquitin Protein Ligase Binding Melanin Biosynthetic Process Melanin Metabolic Process Positive Regulation Of Feeding Behavior Membrane Locomotor Rhythm Positive Regulation Of Bone Resorption Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Platelet Aggregation Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Localization To Cell-cell Junction	Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Feeding Behavior Neuropeptide Signaling Pathway Long-day Photoperiodism Melanocortin Receptor Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Extracellular Space Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Response To Peptide Hormone Generation Of Precursor Metabolites And Energy Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Positive Regulation Of Melanin Biosynthetic Process Extracellular Region Positive Regulation Of Feeding Behavior Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Response To Hormone Pigment Granule Localization Pigment Granule Transport Establishment Of Melanosome Localization Signaling Cell Communication Melanosome Localization Cell-cell Signaling Melanosome Transport Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Positive Regulation Of Behavior Eating Behavior Maternal Process Involved In Female Pregnancy Epigenetic Programming Of Gene Expression G Protein-coupled Receptor Signaling Pathway Melanosome Organization