ASIP

Description		agouti signaling protein
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Epigenetic Regulation Of Gene Expression Melanin Biosynthetic Process Pigmentation Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Melanin Biosynthetic Process
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 18488028 25963972) Tanning ( 23548203) Vitiligo ( 27723757)
Interacting Genes		6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		434
HPRD ID		02562
Ensembl ID		ENSG00000101440
Uniprot IDs		P42127
PDB IDs		1Y7J 1Y7K 2KZA 2L1J
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Feeding Behavior G Protein-coupled Receptor Signaling Pathway Regulation Of Behavior Hormone Binding Neuropeptide Binding Plasma Membrane Corticotropin Receptor Activity Homoiothermy Response To Melanocyte-stimulating Hormone Memory T Cell Extravasation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway T Cell Extravasation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Regulation Of Eating Behavior UV Protection Signal Transduction UV-damage Excision Repair Ubiquitin Protein Ligase Binding Melanin Biosynthetic Process Melanin Metabolic Process Positive Regulation Of Feeding Behavior Membrane Locomotor Rhythm Positive Regulation Of Bone Resorption Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Platelet Aggregation Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Localization To Cell-cell Junction
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