ASIP

Gene Name		agouti signaling protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space
	Molecular Function	Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Genetic Imprinting
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 22976474) Burning and freckling ( 18488028) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Melanoma ( 21983787) Red vs. non-red hair color ( 18488028) Skin sensitivity to sun ( 18488028) Tanning ( 23548203)
Protein-protein Interactions		6 interactors: F11R MC1R MC2R MC3R MC4R MC5R
Entrez ID		434
HPRD ID		02562
Ensembl ID		ENSG00000101440
Uniprot IDs		P42127
PDB IDs		1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Feeding Behavior Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Homoiothermy Regulation Of Blood Pressure Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Protein Kinase A Signaling UV-damage Excision Repair Establishment Of Endothelial Intestinal Barrier Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Response To Stimulus Regulation Of Grooming Behavior Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Rho GTPase Activity UV Protection Positive Regulation Of Bone Resorption Regulation Of Protein Kinase A Signaling Positive Regulation Of Rap GTPase Activity Regulation Of Protein Kinase C Signaling Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Negative Regulation Of Ras GTPase Activity Response To Radiation Regulation Of Rap GTPase Activity Secondary Metabolite Biosynthetic Process Intestinal Absorption Sodium Ion Homeostasis Temperature Homeostasis Regulation Of Rap Protein Signal Transduction
Tagcloud ?		agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1