ASIP and F11R

Number of citations of the paper that reports this interaction (PubMedID 11447115)
43

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ASIP	F11R
Description		agouti signaling protein	F11 receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Protein-containing Complex Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Epigenetic Regulation Of Gene Expression Melanin Biosynthetic Process Pigmentation Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Melanin Biosynthetic Process	Regulation Of Cytokine Production System Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Cell Differentiation Epithelial Cell Differentiation Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Symbiont Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Biological Quality Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Bicellular Tight Junction Assembly
Pathways			Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 18488028 25963972) Tanning ( 23548203) Vitiligo ( 27723757)	Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)
Interacting Genes		6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R	30 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B
Entrez ID		434	50848
HPRD ID		02562	12038
Ensembl ID		ENSG00000101440	ENSG00000158769
Uniprot IDs		P42127	Q6FIB4 Q9Y624
PDB IDs		1Y7J 1Y7K 2KZA 2L1J	1NBQ 3EOY 3TSZ 4ODB
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Feeding Behavior G Protein-coupled Receptor Signaling Pathway Regulation Of Behavior Hormone Binding Neuropeptide Binding Plasma Membrane Corticotropin Receptor Activity Homoiothermy Response To Melanocyte-stimulating Hormone Memory T Cell Extravasation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway T Cell Extravasation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Regulation Of Eating Behavior UV Protection Signal Transduction UV-damage Excision Repair Ubiquitin Protein Ligase Binding Melanin Biosynthetic Process Melanin Metabolic Process Positive Regulation Of Feeding Behavior Membrane Locomotor Rhythm Positive Regulation Of Bone Resorption Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Platelet Aggregation Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Localization To Cell-cell Junction	Localization Within Membrane Plasma Membrane Membrane Cell-cell Junction Organization Establishment Of Protein Localization To Membrane Cell-cell Junction Assembly Cell Junction Assembly Cell Junction Organization Protein Insertion Into ER Membrane Cell Junction Cellular Localization Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Bicellular Tight Junction Tight Junction Assembly Tight Junction Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Membrane Regulation Of Insulin Secretion Protein Insertion Into Membrane Cellular Component Maintenance Establishment Of Protein Localization Establishment Of Endothelial Intestinal Barrier Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Peptide Hormone Secretion Protein Targeting Cell-cell Junction Regulation Of Actin Filament-based Process Cell Adhesion Molecule Binding Cell-cell Junction Maintenance Signaling Receptor Binding Anchoring Junction Intracellular Protein Localization Regulation Of Protein Localization Positive Regulation Of Calcium Ion Import Regulation Of Cell Junction Assembly Regulation Of Hormone Secretion Regulation Of Protein Secretion Glial Cell Migration Apical Junction Complex Regulation Of Actin Filament Organization Negative Regulation Of Protein Catabolic Process Melanocortin Receptor Binding Epithelial Cell Development Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway
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