MC4R and AGRP

Number of citations of the paper that reports this interaction (PubMedID 12815165)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo, in vitro)

		MC4R	AGRP
Description		melanocortin 4 receptor	agouti related neuropeptide
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Neuronal Cell Body
	Molecular Function	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Type 1 Melanocortin Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Feeding Behavior Regulation Of Metabolic Process Insulin Secretion Response To Food Response To Insulin Positive Regulation Of Bone Resorption Regulation Of Feeding Behavior Regulation Of Eating Behavior Response To Melanocyte-stimulating Hormone	Neuropeptide Signaling Pathway Circadian Rhythm Feeding Behavior Adult Feeding Behavior Hormone-mediated Signaling Pathway Response To Insulin Eating Behavior Long-day Photoperiodism Maternal Process Involved In Female Pregnancy Regulation Of Feeding Behavior Positive Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Bremelanotide Setmelanotide
Diseases
GWAS		Adult body size ( 32376654) Antipsychotic drug-induced weight gain ( 22566560) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat percentage ( 26833246) Body mass index ( 18454148 19079260 19079261 20935630 23563607 23669352 24064335 24348519 24861553 25673413 25953783 26426971 26961502 28448500 28552196 28892062 29273807 29381148 31453325) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Childhood body mass index ( 26604143 33045005) Childhood onset type 2 diabetes ( 33479058) Cobalt levels ( 26025379) Coffee consumption ( 31046077) Coffee consumption (cups per day) ( 31837886) Coronary artery disease ( 26343387 33020668) Daytime sleep phenotypes ( 27126917) Dentures ( 31235808) Diastolic blood pressure ( 27841878) Fat body mass ( 24064335) Fatty acid desaturase activity (serum) ( 30453627) Femoral neck bone mineral density ( 30172743) Free thyroxine concentration ( 30367059) Fruit consumption ( 32066663) Hand grip strength ( 29691431) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 28334899 30698716 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heel bone mineral density ( 30598549) Height ( 20881960 25282103 25429064 31562340) Hip circumference ( 25673412 28552196 31453325) Hip circumference variance ( 31453325) Leg fat mass and leg lean mass (pleiotropy) ( 32719433) Leg lean mass (fat adjusted) ( 32719433) Metabolic syndrome ( 31589552) Myocardial infarction ( 33532862) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 19151714 23563607) Obesity (early onset extreme) ( 20421936 23563609) Obesity (extreme) ( 30677029) Obesity-related traits ( 22013104) Systolic blood pressure ( 30224653) Total body bone mineral density ( 30172743) Triglyceride levels ( 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 28869590 30054458 30297969 30718926 32499647) Ulna and radius bone mineral density ( 30172743) Urate levels ( 23263486 31578528) Waist circumference ( 19557197 25673412 28552196 31453325) Waist circumference and related phenotypes ( 18454146) Waist circumference variance ( 31453325) Waist-hip ratio ( 25673412) Weight ( 19079260)	Blood protein levels ( 30072576) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		20 interacting genes: AGRP AIG1 ASIP ATP6V0E2 ATRNL1 CD81 GRK2 IL1RAP MAL MC1R NPC1 NPY PDIA6 PLLP POMC PRKACA TMEM19 TMEM94 TSPAN3 YIPF3	4 interacting genes: GHRL MC3R MC4R MC5R
Entrez ID		4160	181
HPRD ID		01116	09079
Ensembl ID		ENSG00000166603	ENSG00000159723
Uniprot IDs		P32245	C6SUN5 O00253
PDB IDs		6W25 7AUE 7F53 7F54 7F55 7F58 7PIU 7PIV 8QJ2 8WKY 8WKZ	1HYK 1MR0
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior Positive Regulation Of Feeding Behavior Neuropeptide Hormone Activity Positive Regulation Of Behavior Regulation Of Feeding Behavior Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding G Protein-coupled Receptor Signaling Pathway Pigmentation Adult Behavior Structural Constituent Of Myelin Sheath G Protein-coupled Receptor Binding Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Feeding Behavior Neuropeptide Signaling Pathway Symbiont Entry Into Host Cell Membrane Chemical Homeostasis Regulation Of Appetite Photoperiodism Membrane Raft Organization Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Relaxation Of Smooth Muscle Biological Process Involved In Interaction With Host Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Signaling Receptor Binding Long-day Photoperiodism Secondary Metabolic Process Melanocortin Receptor Binding Cell Communication Cellular Response To Lipoprotein Particle Stimulus Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Protein Insertion Into Plasma Membrane Plasma Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Intracellular Monoatomic Ion Homeostasis Short-day Photoperiodism Intracellular Monoatomic Cation Homeostasis Cyclodextrin Metabolic Process Positive Regulation Of Oxytocin Production P-type Magnesium Transporter Activity Magnesium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Macroautophagy Plasma Membrane Cholesterol Binding	Melanocortin Receptor Activity Regulation Of Feeding Behavior Melanocyte-stimulating Hormone Receptor Activity Regulation Of Behavior Regulation Of Eating Behavior Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neuropeptide Binding G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Peptide Hormone Secretion Peptide Secretion Feeding Behavior Hormone Transport Hormone Secretion Peptide Transport Ghrelin Receptor Binding Cortisol Secretion Positive Regulation Of Gastric Mucosal Blood Circulation Homoiothermy Amide Transport Response To Melanocyte-stimulating Hormone Growth Hormone-releasing Hormone Activity Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Small Intestinal Transit Positive Regulation Of Growth Rate Signal Release Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Bone Development Positive Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation Of Eating Behavior Positive Regulation Of Cortisol Secretion Positive Regulation Of Response To Food Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Appetite Regulation Of Gastric Motility Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Neuronal Dense Core Vesicle Lumen Regulation Of Growth Rate Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Blood Circulation Growth Hormone Secretion Positive Regulation Of Corticotropin Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Corticotropin Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Gastric Acid Secretion Positive Regulation Of Growth Hormone Secretion
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