ASIP and MC1R

Number of citations of the paper that reports this interaction (PubMedID 9058374)
0

Data Source:
HPRD (in vivo)

		ASIP	MC1R
Description		agouti signaling protein	melanocortin 1 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Ubiquitin Protein Ligase Binding Hormone Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Epigenetic Regulation Of Gene Expression Melanin Biosynthetic Process Pigmentation Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Melanin Biosynthetic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway UV Protection Regulation Of Gene Expression Sensory Perception Of Pain Negative Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Melanin Biosynthetic Process Pigmentation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Feeding Behavior UV-damage Excision Repair Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Feeding Behavior
Pathways			Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Afamelanotide CZEN 002 Bremelanotide
Diseases
GWAS		Blood protein levels ( 30072576) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 18488028 25963972) Tanning ( 23548203) Vitiligo ( 27723757)	Basal cell carcinoma ( 27539887 21700618 31174203) Black vs. non-black hair color ( 26184321) Black vs. red hair color ( 18483556) Blond vs. brown hair color ( 17952075) Blond vs. brown/black hair color ( 30531825) Brain morphology (MOSTest) ( 32665545) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Cutaneous squamous cell carcinoma ( 27424798) Facial pigmentation ( 25705849) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 20585627 29662168 23548203) Hair morphology traits ( 30166351) Hemoglobin levels ( 32327693) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Melanoma ( 19578364 21983787 28212542 24980573) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-melanoma skin cancer ( 29739929 23548203) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Perceived skin darkness ( 25963972) Red vs non-red hair color ( 26184321 17952075) Red vs. brown/black hair color ( 30531825) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972 17952075) Squamous cell carcinoma ( 26829030) Sunburns ( 23548203) Tanning ( 23548203 19340012) Vitiligo ( 22561518 27723757) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R	3 interacting genes: ASIP MC4R POMC
Entrez ID		434	4157
HPRD ID		02562	01118
Ensembl ID		ENSG00000101440	ENSG00000258839
Uniprot IDs		P42127	Q01726 Q1JUL4
PDB IDs		1Y7J 1Y7K 2KZA 2L1J	7F4D 7F4F 7F4H 7F4I
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Feeding Behavior G Protein-coupled Receptor Signaling Pathway Regulation Of Behavior Hormone Binding Neuropeptide Binding Plasma Membrane Corticotropin Receptor Activity Homoiothermy Response To Melanocyte-stimulating Hormone Memory T Cell Extravasation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway T Cell Extravasation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Regulation Of Eating Behavior UV Protection Signal Transduction UV-damage Excision Repair Ubiquitin Protein Ligase Binding Melanin Biosynthetic Process Melanin Metabolic Process Positive Regulation Of Feeding Behavior Membrane Locomotor Rhythm Positive Regulation Of Bone Resorption Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Platelet Aggregation Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Localization To Cell-cell Junction	Response To Melanocyte-stimulating Hormone Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Pigmentation Feeding Behavior Melanocortin Receptor Binding Regulation Of Leukocyte Mediated Cytotoxicity Positive Regulation Of Oxytocin Production Positive Regulation Of Neutrophil Mediated Killing Of Fungus Carbohydrate Homeostasis T Cell Antigen Processing And Presentation Glucose Homeostasis Melanocyte-stimulating Hormone Receptor Activity Cellular Pigmentation Type 1 Melanocortin Receptor Binding Positive Regulation Of Killing Of Cells Of Another Organism Membrane To Membrane Docking T Cell Extravasation Melanocortin Receptor Activity Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Receptor-mediated Virion Attachment To Host Cell T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Response To Peptide Hormone Regulation Of Eating Behavior Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Adult Feeding Behavior Extracellular Space Virion Attachment To Host Cell Adhesion Of Symbiont To Host Cell Signaling Receptor Binding Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Melanin Biosynthetic Process Adhesion Of Symbiont To Host Positive Regulation Of Bone Resorption Positive Regulation Of Cellular Extravasation Cellular Extravasation Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Regulation Of Hormone Levels Regulation Of Appetite Pigment Granule Localization Neuropeptide Binding
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