MC4R and ATRNL1

Number of citations of the paper that reports this interaction (PMID 14531729)
4

Data Source:
HPRD (two hybrid, in vitro)

		MC4R	ATRNL1
Gene Name		melanocortin 4 receptor	attractin-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Ubiquitin Protein Ligase Binding Neuropeptide Binding	Receptor Activity Carbohydrate Binding
	Biological Process	Diet Induced Thermogenesis Energy Reserve Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Feeding Behavior Insulin Secretion Positive Regulation Of CAMP Biosynthetic Process Response To Insulin Positive Regulation Of Bone Resorption Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Antipsychotic drug-induced weight gain ( 22566560) Body mass index ( 22344221 23563607 19079260 19079261 23669352 18454148 20935630) HDL cholesterol ( 20686565) Height ( 20881960) Obesity ( 23563607 19151714) Obesity (early onset extreme) ( 23563609) Obesity (extreme) ( 20421936) Obesity and blood pressure ( 22013104) Urate levels ( 23263486) Waist circumference ( 19557197) Waist circumference and related phenotypes ( 18454146) Weight ( 19079260)	Information processing speed ( 21130836)
Protein-Protein Interactions		9 interactors: ADRBK1 AGRP ASIP ATRNL1 IL1RAP MC1R NPY POMC PRKACA	1 interactors: MC4R
Entrez ID		4160	26033
HPRD ID		01116	12504
Ensembl ID		ENSG00000166603	ENSG00000107518
Uniprot IDs		P32245	Q5VV63
PDB IDs		2IQP 2IQR 2IQS 2IQU 2IQV 2IQW
Enriched GO Terms of Interacting Partners?		Adult Feeding Behavior G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Feeding Behavior Cell Surface Receptor Signaling Pathway Signal Transduction Signaling Cell Communication Neuropeptide Signaling Pathway Feeding Behavior Pigmentation Cellular Response To Stimulus Regulation Of Feeding Behavior Positive Regulation Of Behavior Melanin Biosynthetic Process Melanin Metabolic Process Adult Behavior Regulation Of Appetite Secondary Metabolite Biosynthetic Process Regulation Of Behavior Regulation Of The Force Of Heart Contraction Response To Stimulus Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Peptidyl-threonine Phosphorylation Activation Of Phospholipase C Activity Blood Circulation Positive Regulation Of Phospholipase C Activity Response To Light Stimulus Pigment Biosynthetic Process Cellular Pigmentation Cell-cell Signaling Positive Regulation Of CAMP Biosynthetic Process Cellular Response To Organic Substance Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Phospholipase Activity Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Generation Of Precursor Metabolites And Energy Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Positive Regulation Of Lipase Activity Regulation Of CAMP Biosynthetic Process Response To Radiation Single-organism Behavior Cellular Response To Light Stimulus Regulation Of Tumor Necrosis Factor Production Phenol-containing Compound Metabolic Process Regulation Of CAMP Metabolic Process Histone H3-T6 Phosphorylation	Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior Regulation Of Feeding Behavior Positive Regulation Of Bone Resorption Response To Dietary Excess Positive Regulation Of Tissue Remodeling Regulation Of Bone Resorption Insulin Secretion Regulation Of Bone Remodeling Positive Regulation Of CAMP Biosynthetic Process Peptide Hormone Secretion Regulation Of Tissue Remodeling Positive Regulation Of CAMP Metabolic Process Peptide Secretion Positive Regulation Of Cyclic Nucleotide Metabolic Process Hormone Secretion Regulation Of CAMP Biosynthetic Process Hormone Transport Peptide Transport Feeding Behavior Regulation Of CAMP Metabolic Process Protein Secretion Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Amide Transport Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Regulation Of Hormone Levels Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Generation Of Precursor Metabolites And Energy Response To Nutrient Levels Response To Peptide Hormone Response To Extracellular Stimulus Response To Peptide Secretion By Cell Behavior Secretion
Tagcloud ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s
Tagcloud (Difference) ?		5i correcting d90n delta88 f261s functionally g98r hek293 i102s i335s impermeable inactivating intracellularly ipsen mc3r mc4rs melanocortin misrouted mutants n274s opioid permeable pharmacoperone rescue rescued retained s58c trafficking y157s
Tagcloud (Intersection) ?