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MC4R
Gene Name
melanocortin 4 receptor
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Melanocortin Receptor Activity
Melanocyte-stimulating Hormone Receptor Activity
Protein Binding
Peptide Hormone Binding
Ubiquitin Protein Ligase Binding
Neuropeptide Binding
Biological Process
Diet Induced Thermogenesis
Energy Reserve Metabolic Process
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Feeding Behavior
Insulin Secretion
Positive Regulation Of CAMP Biosynthetic Process
Response To Insulin
Positive Regulation Of Bone Resorption
Negative Regulation Of Feeding Behavior
Regulation Of Grooming Behavior
Pathways
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
Signaling by GPCR
GPCR downstream signaling
Peptide ligand-binding receptors
G alpha (s) signalling events
Class A/1 (Rhodopsin-like receptors)
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Drugs
Diseases
GWAS
Antipsychotic drug-induced weight gain (
22566560
)
Body mass index (
22344221
23563607
19079260
19079261
23669352
18454148
20935630
)
HDL cholesterol (
20686565
)
Height (
20881960
)
Obesity (
23563607
19151714
)
Obesity (early onset extreme) (
23563609
)
Obesity (extreme) (
20421936
)
Obesity and blood pressure (
22013104
)
Urate levels (
23263486
)
Waist circumference (
19557197
)
Waist circumference and related phenotypes (
18454146
)
Weight (
19079260
)
Protein-protein Interactions
9 interactors:
ADRBK1
AGRP
ASIP
ATRNL1
IL1RAP
MC1R
NPY
POMC
PRKACA
Entrez ID
4160
HPRD ID
01116
Ensembl ID
ENSG00000166603
Uniprot IDs
P32245
PDB IDs
2IQP
2IQR
2IQS
2IQU
2IQV
2IQW
Enriched GO Terms of Interacting Partners
?
Adult Feeding Behavior
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Feeding Behavior
Cell Surface Receptor Signaling Pathway
Signal Transduction
Signaling
Cell Communication
Neuropeptide Signaling Pathway
Feeding Behavior
Pigmentation
Cellular Response To Stimulus
Regulation Of Feeding Behavior
Positive Regulation Of Behavior
Melanin Biosynthetic Process
Melanin Metabolic Process
Adult Behavior
Regulation Of Appetite
Secondary Metabolite Biosynthetic Process
Regulation Of Behavior
Regulation Of The Force Of Heart Contraction
Response To Stimulus
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Peptidyl-threonine Phosphorylation
Activation Of Phospholipase C Activity
Blood Circulation
Positive Regulation Of Phospholipase C Activity
Response To Light Stimulus
Pigment Biosynthetic Process
Cellular Pigmentation
Cell-cell Signaling
Positive Regulation Of CAMP Biosynthetic Process
Cellular Response To Organic Substance
Positive Regulation Of CAMP Metabolic Process
Positive Regulation Of Phospholipase Activity
Positive Regulation Of Dense Core Granule Biogenesis
Negative Regulation Of The Force Of Heart Contraction By Chemical Signal
Generation Of Precursor Metabolites And Energy
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Regulation Of Phospholipase Activity
Regulation Of Striated Muscle Contraction
Positive Regulation Of Lipase Activity
Regulation Of CAMP Biosynthetic Process
Response To Radiation
Single-organism Behavior
Cellular Response To Light Stimulus
Regulation Of Tumor Necrosis Factor Production
Phenol-containing Compound Metabolic Process
Regulation Of CAMP Metabolic Process
Histone H3-T6 Phosphorylation
Tagcloud
?
5i
correcting
d90n
delta88
f261s
functionally
g98r
hek293
i102s
i335s
impermeable
inactivating
intracellularly
ipsen
mc3r
mc4rs
melanocortin
misrouted
mutants
n274s
opioid
permeable
pharmacoperone
rescue
rescued
retained
s58c
trafficking
y157s