ASIP and MC3R

Number of citations of the paper that reports this interaction (PubMedID 9058374)
0

Data Source:
HPRD (in vitro)

		ASIP	MC3R
Description		agouti signaling protein	melanocortin 3 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Neuropeptide Hormone Activity Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding	G Protein-coupled Receptor Activity Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Epigenetic Regulation Of Gene Expression Melanin Biosynthetic Process Pigmentation Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Melanin Biosynthetic Process	Regulation Of Heart Rate Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Circadian Regulation Of Gene Expression Homoiothermy Locomotor Rhythm Rhythmic Process Sodium Ion Homeostasis Regulation Of Feeding Behavior
Pathways			Peptide ligand-binding receptors G alpha (s) signalling events Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs			Bremelanotide
Diseases
GWAS		Blood protein levels ( 30072576) Breast cancer ( 22976474) Burning and freckling ( 18488028) Facial pigmentation ( 25705849) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Low tan response ( 29739929) Melanoma ( 21983787 28212542) Nevus count or cutaneous melanoma ( 30429480) Non-melanoma skin cancer ( 29739929) Red vs. non-red hair color ( 18488028) Skin colour saturation ( 25963972) Skin pigmentation ( 28300201) Skin sensitivity to sun ( 18488028 25963972) Tanning ( 23548203) Vitiligo ( 27723757)	Adult body size ( 32376654) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: F11R MC1R MC2R MC3R MC4R MC5R	4 interacting genes: AGRP ASIP CFTR POMC
Entrez ID		434	4159
HPRD ID		02562	01115
Ensembl ID		ENSG00000101440	ENSG00000124089
Uniprot IDs		P42127	P41968
PDB IDs		1Y7J 1Y7K 2KZA 2L1J	8IOC 8KIG
Enriched GO Terms of Interacting Partners?		Melanocortin Receptor Activity Melanocyte-stimulating Hormone Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Regulation Of Feeding Behavior G Protein-coupled Receptor Signaling Pathway Regulation Of Behavior Hormone Binding Neuropeptide Binding Plasma Membrane Corticotropin Receptor Activity Homoiothermy Response To Melanocyte-stimulating Hormone Memory T Cell Extravasation Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway T Cell Extravasation Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Regulation Of Eating Behavior UV Protection Signal Transduction UV-damage Excision Repair Ubiquitin Protein Ligase Binding Melanin Biosynthetic Process Melanin Metabolic Process Positive Regulation Of Feeding Behavior Membrane Locomotor Rhythm Positive Regulation Of Bone Resorption Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Platelet Aggregation Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Positive Regulation Of Homotypic Cell-cell Adhesion Protein Localization To Cell-cell Junction	Type 1 Melanocortin Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding Adult Feeding Behavior Neuropeptide Hormone Activity Signaling Receptor Binding Pigmentation Neuropeptide Signaling Pathway Feeding Behavior Long-day Photoperiodism Melanocortin Receptor Binding Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Oxytocin Production Adult Behavior Hormone-mediated Signaling Pathway Positive Regulation Of Anion Channel Activity Positive Regulation Of Neutrophil Mediated Killing Of Fungus Response To Melanocyte-stimulating Hormone Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Cellular Pigmentation Positive Regulation Of Killing Of Cells Of Another Organism Transepithelial Water Transport Regulation Of Hormone Secretion Positive Regulation Of Tooth Mineralization Regulation Of Corticosterone Secretion Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Neutrophil Mediated Cytotoxicity Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Peptide Hormone Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Generation Of Precursor Metabolites And Energy Positive Regulation Of Melanin Biosynthetic Process Amelogenesis Extracellular Space ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Positive Regulation Of Feeding Behavior Melanin Biosynthetic Process Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Melanin Metabolic Process Regulation Of Melanin Biosynthetic Process Epigenetic Programming In The Zygotic Pronuclei Cellular Response To Forskolin
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