ASIP and MC2R

Number of citations of the paper that reports this interaction (PMID 9058374)
19

Data Source:
HPRD (in vitro)

		ASIP	MC2R
Gene Name		agouti signaling protein	melanocortin 2 receptor (adrenocorticotropic hormone)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Type 3 Melanocortin Receptor Binding Type 4 Melanocortin Receptor Binding	Melanocortin Receptor Activity Corticotropin Receptor Activity Protein Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Signal Transduction Cell-cell Signaling Adult Feeding Behavior Hormone-mediated Signaling Pathway Melanosome Transport Melanosome Organization Regulation Of Molecular Function, Epigenetic Melanin Biosynthetic Process Genetic Imprinting	Placenta Development G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors G alpha (s) signalling events Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes
Drugs			Cosyntropin Corticotropin
Diseases
GWAS		Breast cancer ( 22976474) Burning and freckling ( 18488028) Freckles ( 18488028) Freckling ( 20585627) Hair color ( 20585627) Melanoma ( 21983787) Red vs. non-red hair color ( 18488028) Skin sensitivity to sun ( 18488028) Tanning ( 23548203)
Protein-Protein Interactions		6 interactors: F11R MC1R MC2R MC3R MC4R MC5R	2 interactors: ASIP POMC
Entrez ID		434	4158
HPRD ID		02562	06304
Ensembl ID		ENSG00000101440	ENSG00000185231
Uniprot IDs		P42127	Q01718
PDB IDs		1Y7J 1Y7K 2IQW 2KZA 2L1J
Enriched GO Terms of Interacting Partners?		Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Coupled Receptor Signaling Pathway Regulation Of Feeding Behavior Regulation Of Phosphorus Metabolic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Signal Transduction Signaling Cell Communication Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Stimulus Homoiothermy Regulation Of Blood Pressure Regulation Of Behavior Positive Regulation Of Feeding Behavior Regulation Of Metabolic Process Positive Regulation Of Protein Kinase A Signaling UV-damage Excision Repair Establishment Of Endothelial Intestinal Barrier Diet Induced Thermogenesis Negative Regulation Of Feeding Behavior Response To Stimulus Regulation Of Grooming Behavior Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Positive Regulation Of Protein Kinase C Signaling Negative Regulation Of Rho GTPase Activity UV Protection Positive Regulation Of Bone Resorption Regulation Of Protein Kinase A Signaling Positive Regulation Of Rap GTPase Activity Regulation Of Protein Kinase C Signaling Response To Dietary Excess Melanin Biosynthetic Process Melanin Metabolic Process Negative Regulation Of Ras GTPase Activity Response To Radiation Regulation Of Rap GTPase Activity Secondary Metabolite Biosynthetic Process Intestinal Absorption Sodium Ion Homeostasis Temperature Homeostasis Regulation Of Rap Protein Signal Transduction	Cellular Pigmentation Pigmentation Regulation Of Molecular Function, Epigenetic Regulation Of Corticosterone Secretion Generation Of Precursor Metabolites And Energy Adult Feeding Behavior Melanin Biosynthetic Process Cell-cell Signaling Melanin Metabolic Process Regulation Of Appetite Melanosome Organization Secondary Metabolite Biosynthetic Process Pigment Granule Organization Genetic Imprinting Melanosome Transport Peptide Hormone Processing Pigment Granule Transport Establishment Of Melanosome Localization Regulation Of Glycogen Metabolic Process Negative Regulation Of Tumor Necrosis Factor Production Melanosome Localization Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Pigment Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Lipid Transport Neuropeptide Signaling Pathway Regulation Of Tumor Necrosis Factor Production Feeding Behavior Phenol-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Hormone-mediated Signaling Pathway Peptide Metabolic Process Regulation Of Carbohydrate Metabolic Process Adult Behavior Regulation Of Blood Pressure Hormone Metabolic Process Establishment Of Vesicle Localization Glucose Homeostasis Negative Regulation Of Cytokine Production Vesicle Organization Vesicle Localization
Tagcloud ?		agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	acth adrenocorticotropic ancestry collaborative constitute contributions corticotropin cortisol critical critically employing eunice ga genotype gestation gg ill illness kennedy nucleotide observational pediatric personalized portion rs1941088 shriver tag variability varies
Tagcloud (Difference) ?		agouti albinism atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1	acth adrenocorticotropic ancestry collaborative constitute contributions corticotropin cortisol critical critically employing eunice ga genotype gestation gg ill illness kennedy nucleotide observational pediatric personalized portion rs1941088 shriver tag variability varies
Tagcloud (Intersection) ?