FBN2 and SLC27A6

Data Source: HiPPIP (Novel)

		FBN2	SLC27A6
Name		fibrillin 2	solute carrier family 27 member 6
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Extracellular Matrix	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Sarcolemma
	Molecular Function	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid Transmembrane Transporter Activity Fatty Acid Transmembrane Transporter Activity Ligase Activity Very Long-chain Fatty Acid-CoA Ligase Activity Arachidonate-CoA Ligase Activity
	Biological Process	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Transport Long-chain Fatty Acid Transport Long-chain Fatty Acid Import Into Cell
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Transport of fatty acids
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome	None
GWAS		Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )	Appendicular lean mass ( 33097823 ) Atrial fibrillation ( 29892015 30061737 ) Brain morphology (MOSTest) ( 32665545 ) Congenital right-sided heart lesions ( 33201861 ) Cortical surface area (MOSTest) ( 32665545 ) Night sleep phenotypes ( 27126917 ) PR interval ( 32439900 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1	6 interacting genes: CHD3 CUTC RACK1 TMEM62 TNFRSF10C VIM
Entrez ID		2201	28965
HPRD ID		00416	09173
Ensembl ID		ENSG00000138829	ENSG00000113396
Uniprot IDs		P35556	B2R8P6 Q9Y2P4
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity	None