FBN2 and ELN

Number of citations of the paper that reports this interaction (PMID 10825173)
14

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		FBN2	ELN
Gene Name		fibrillin 2	elastin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Elastic Fiber
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Positive Regulation Of Osteoblast Differentiation Bone Trabecula Formation	Respiratory Gaseous Exchange Blood Circulation Cell Proliferation Organ Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix	Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs			Rofecoxib
Diseases
GWAS		Height ( 21998595) Obesity (extreme) ( 19553259) Temperament ( 22832960)
Protein-Protein Interactions		7 interactors: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2	21 interactors: ASS1 BGN CKMT2 CLU DCN ELANE FBLN1 FBLN2 FBN1 FBN2 FCN1 FKBP10 LGALS3 LOX LOXL1 LYZ MAGEH1 MFAP2 NID2 PRTN3 SPINK1
Entrez ID		2201	2006
HPRD ID		00416	00556
Ensembl ID		ENSG00000138829	ENSG00000049540
Uniprot IDs		P35556	B3KRT8 B4E3S4 E7EN65 E7ENM0 G3V0G6 G5E950 P15502 Q59H17 Q6ZUN2 Q8NBI4
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of BMP Signaling Pathway Dendrite Regeneration Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Maintenance Of Protein Location Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Sequestering Of BMP In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway System Development Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Extracellular Fibril Organization Kidney Development SMAD Protein Complex Assembly Negative Regulation Of Signaling Renal System Development Paraxial Mesoderm Morphogenesis Stress Fiber Assembly Multicellular Organismal Development Nodal Signaling Pathway Urogenital System Development Anatomical Structure Development Organ Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Platelet Formation Embryonic Foregut Morphogenesis Platelet Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Response To Other Organism Response To Biotic Stimulus Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Response To Bacterium Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Extracellular Negative Regulation Of Signal Transduction Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Chondroitin Sulfate Biosynthetic Process Regulation Of Calcium Ion Import Chondroitin Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Interleukin-8 Production Response To External Stimulus Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Lipid Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Peptide Cross-linking Defense Response Negative Regulation Of Endocytosis Multicellular Organismal Development Argininosuccinate Metabolic Process Negative Regulation Of Immunological Synapse Formation Positive Regulation Of Tau-protein Kinase Activity Regulation Of Neuronal Signal Transduction Microglial Cell Proliferation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process System Development Response To Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Collagen Catabolic Process Wound Healing Immune System Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Neurofibrillary Tangle Assembly Protein Deamination Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Cellular Response To Amine Stimulus Neutrophil Mediated Killing Of Fungus
Tagcloud ?		aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Difference) ?		aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1	additive amounts bioactive compound cosmetics curcuma curcumin detroit elastic elastin enhance extract fbn1 fibers fibrillin fibroblast food foods generally herbal longa medicine mum polyphenol promoters rhizome spice tropoelastin yellow
Tagcloud (Intersection) ?