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FBN2
Description
fibrillin 2
Image
No pdb structure
GO Annotations
Cellular Component
Microfibril
Extracellular Region
Extracellular Space
Extracellular Matrix
Molecular Function
Hormone Activity
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Extracellular Matrix Constituent Conferring Elasticity
Biological Process
Placenta Development
Glucose Metabolic Process
Signal Transduction
Embryonic Limb Morphogenesis
Positive Regulation Of Bone Mineralization
Limb Morphogenesis
Sequestering Of TGFbeta In Extracellular Matrix
Glucose Homeostasis
Camera-type Eye Development
Positive Regulation Of Osteoblast Differentiation
Embryonic Eye Morphogenesis
Bone Trabecula Formation
Regulation Of Trophoblast Cell Migration
Pathways
Degradation of the extracellular matrix
Elastic fibre formation
Molecules associated with elastic fibres
Molecules associated with elastic fibres
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Diseases
Congenital contractural arachnodactyly (CCA) ; Beals syndrome
GWAS
Atrial fibrillation (
29892015
)
Beard thickness (
26926045
)
Brain morphology (MOSTest) (
32665545
)
Breastfeeding duration (
25475840
)
Central corneal thickness (
32528159
)
Cortical surface area (MOSTest) (
32665545
)
Diastolic blood pressure (
27841878
)
Heel bone mineral density (
30598549
)
Height (
21998595
31562340
)
Heschl's gyrus morphology (
25130324
)
Hip circumference adjusted for BMI (
34021172
)
Intraocular pressure (
29617998
)
Medication use (beta blocking agents) (
31015401
)
Medication use (calcium channel blockers) (
31015401
)
Medication use (diuretics) (
31015401
)
Multiple system atrophy (
27629089
)
Night sleep phenotypes (
27126917
)
Obesity (extreme) (
19553259
)
Pulse pressure (
30578418
27841878
)
Refractive error (
32231278
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Severe aplastic anemia (
32004448
)
Subcortical volume (MOSTest) (
32665545
)
Systemic lupus erythematosus (
32771030
)
Systolic blood pressure (
30578418
28135244
27841878
)
Temperament (
22832960
)
Waist circumference adjusted for body mass index (
34021172
)
Novel Interacting Genes
15 novel interacting genes:
CMBL
CSF2
DPYSL5
DUSP5
FDPS
ITGA2
NDUFB6
NRG2
RNF14
SEMA3F
SIRPA
SLC27A6
SNRPB
TRIM24
UBE2B
Interacting Genes
8 interacting genes:
ELN
FBN1
LTBP1
MATN2
MFAP2
MFAP5
SMAD2
THBS1
Entrez ID
2201
HPRD ID
00416
Ensembl ID
ENSG00000138829
Uniprot IDs
P35556
PDB IDs
Enriched GO Terms of Interacting Partners
?
Extracellular Matrix Structural Constituent
Microfibril
Extracellular Matrix
Sequestering Of TGFbeta In Extracellular Matrix
Embryonic Eye Morphogenesis
Embryonic Organ Morphogenesis
Post-embryonic Eye Morphogenesis
Fibrinogen Binding
Animal Organ Morphogenesis
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Sequestering Of Extracellular Ligand From Receptor
Eye Morphogenesis
Extracellular Matrix Constituent Conferring Elasticity
Extracellular Negative Regulation Of Signal Transduction
Sensory Organ Morphogenesis
Endoderm Formation
Extracellular Region
Ubiquitin-like Protein Transferase Activity
Laminin Binding
Transforming Growth Factor Beta Binding
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Cell Adhesion Mediated By Integrin
Extracellular Matrix Binding
Fibronectin Binding
Response To Monosaccharide
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Response To Nutrient Levels
Integrin Binding
Cell Migration
Regulation Of Smooth Muscle Cell Proliferation
Aortic Valve Morphogenesis
Negative Regulation Of Developmental Process
Response To Carbohydrate
Granulocyte Macrophage Colony-stimulating Factor Receptor Binding
Histone H3K23ac Reader Activity
Tagcloud
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