FBN2

Gene Name		fibrillin 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Positive Regulation Of Osteoblast Differentiation Bone Trabecula Formation
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix
Drugs
Diseases
GWAS		Height ( 21998595) Obesity (extreme) ( 19553259) Temperament ( 22832960)
Protein-protein Interactions		7 interactors: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2
Entrez ID		2201
HPRD ID		00416
Ensembl ID		ENSG00000138829
Uniprot IDs		P35556
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of BMP Signaling Pathway Dendrite Regeneration Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Maintenance Of Protein Location Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Sequestering Of BMP In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway System Development Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Extracellular Fibril Organization Kidney Development SMAD Protein Complex Assembly Negative Regulation Of Signaling Renal System Development Paraxial Mesoderm Morphogenesis Stress Fiber Assembly Multicellular Organismal Development Nodal Signaling Pathway Urogenital System Development Anatomical Structure Development Organ Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Platelet Formation Embryonic Foregut Morphogenesis Platelet Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification
Tagcloud ?		aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1