FBN2 and SIRPA

Data Source: HiPPIP (Novel)

		FBN2	SIRPA
Name		fibrillin 2	signal regulatory protein alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Extracellular Matrix	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding
	Biological Process	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome	None
GWAS		Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )	Aortic root size ( 21223598 ) Basophil percentage of granulocytes ( 27863252 ) Blood protein levels ( 30072576 ) High light scatter reticulocyte count ( 32888494 ) Liver enzyme levels (alanine transaminase) ( 24124411 ) Mean platelet volume ( 19820697 22139419 27863252 32888494 ) Platelet count ( 29403010 ) Platelet distribution width ( 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Novel Interactors		15 novel interactors: CMBL CSF2 DPYSL5 DUSP5 FDPS ITGA2 NDUFB6 NRG2 RNF14 SEMA3F SIRPA SLC27A6 SNRPB TRIM24 UBE2B	2 novel interactors: FBN2 RRM1
Interacting Genes		8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1	60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM
Entrez ID		2201	140885
HPRD ID		00416	03912
Ensembl ID		ENSG00000138829	ENSG00000198053
Uniprot IDs		P35556	P78324
PDB IDs		Not available	2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity	Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton