FBN2 and MFAP5

Number of citations: 0 (PubMedID 12122015)
Data Source: HPRD (two hybrid)

		FBN2	MFAP5
Name		fibrillin 2	microfibril associated protein 5
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Microfibril Extracellular Region Extracellular Space Extracellular Matrix	Microfibril Extracellular Region Extracellular Matrix
	Molecular Function	Hormone Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Extracellular Matrix Constituent Conferring Elasticity	Extracellular Matrix Structural Constituent
	Biological Process	Placenta Development Glucose Metabolic Process Signal Transduction Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Limb Morphogenesis Sequestering Of TGFbeta In Extracellular Matrix Glucose Homeostasis Camera-type Eye Development Positive Regulation Of Osteoblast Differentiation Embryonic Eye Morphogenesis Bone Trabecula Formation Regulation Of Trophoblast Cell Migration	Embryonic Eye Morphogenesis Definitive Hemopoiesis Supramolecular Fiber Organization
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	None
Diseases		Congenital contractural arachnodactyly (CCA) ; Beals syndrome	None
GWAS		Atrial fibrillation ( 29892015 ) Beard thickness ( 26926045 ) Brain morphology (MOSTest) ( 32665545 ) Breastfeeding duration ( 25475840 ) Central corneal thickness ( 32528159 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) Heel bone mineral density ( 30598549 ) Height ( 21998595 31562340 ) Heschl's gyrus morphology ( 25130324 ) Hip circumference adjusted for BMI ( 34021172 ) Intraocular pressure ( 29617998 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (calcium channel blockers) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Multiple system atrophy ( 27629089 ) Night sleep phenotypes ( 27126917 ) Obesity (extreme) ( 19553259 ) Pulse pressure ( 30578418 27841878 ) Refractive error ( 32231278 ) Response to fenofibrate (total cholesterol levels) ( 27002377 ) Severe aplastic anemia ( 32004448 ) Subcortical volume (MOSTest) ( 32665545 ) Systemic lupus erythematosus ( 32771030 ) Systolic blood pressure ( 30578418 28135244 27841878 ) Temperament ( 22832960 ) Waist circumference adjusted for body mass index ( 34021172 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2 THBS1	4 interacting genes: FBLN1 FBN1 FBN2 MEGF6
Entrez ID		2201	8076
HPRD ID		00416	03063
Ensembl ID		ENSG00000138829	ENSG00000197614
Uniprot IDs		P35556	B3KW70 F5GYX4 F5H413 Q13361
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Extracellular Matrix Structural Constituent Microfibril Extracellular Matrix Sequestering Of TGFbeta In Extracellular Matrix Embryonic Eye Morphogenesis Embryonic Organ Morphogenesis Post-embryonic Eye Morphogenesis Fibrinogen Binding Animal Organ Morphogenesis Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Eye Morphogenesis Extracellular Matrix Constituent Conferring Elasticity Extracellular Negative Regulation Of Signal Transduction Sensory Organ Morphogenesis Endoderm Formation Extracellular Region Ubiquitin-like Protein Transferase Activity Laminin Binding Transforming Growth Factor Beta Binding Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Mediated By Integrin Extracellular Matrix Binding Fibronectin Binding Response To Monosaccharide Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Response To Nutrient Levels Integrin Binding Cell Migration Regulation Of Smooth Muscle Cell Proliferation Aortic Valve Morphogenesis Negative Regulation Of Developmental Process Response To Carbohydrate Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Histone H3K23ac Reader Activity	Sequestering Of TGFbeta In Extracellular Matrix Calcium Ion Binding Extracellular Matrix Structural Constituent Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Extracellular Matrix Constituent Conferring Elasticity Microfibril Embryonic Eye Morphogenesis Extracellular Matrix Eye Morphogenesis Maintenance Of Protein Location Sensory Organ Morphogenesis Maintenance Of Location Camera-type Eye Development Basement Membrane Extracellular Region Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hormone Activity Embryonic Organ Morphogenesis Eye Development Glucose Metabolic Process Integrin Binding Negative Regulation Of Transformation Of Host Cell By Virus Activation Of Protein Kinase A Activity Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hexose Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Sensory Organ Development Regulation Of Transformation Of Host Cell By Virus Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Monosaccharide Metabolic Process Carbohydrate Homeostasis Glucose Homeostasis Sequestering Of BMP In Extracellular Matrix Positive Regulation Of Response To Food Positive Regulation Of Appetite Elastic Fiber Negative Regulation Of Osteoclast Development Fibrinogen Binding Post-embryonic Eye Morphogenesis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Bone Trabecula Formation Negative Regulation Of Signal Transduction Peptidase Activator Activity Blood Coagulation, Fibrin Clot Formation Regulation Of Osteoclast Development Regulation Of Cellular Response To Growth Factor Stimulus Protein-containing Complex Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling