FBN2 and MFAP2

Number of citations of the paper that reports this interaction (PMID 15044481)
9

Data Source:
HPRD (two hybrid, in vitro)

		FBN2	MFAP2
Gene Name		fibrillin 2	microfibrillar-associated protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Microfibril Extracellular Region Proteinaceous Extracellular Matrix Extracellular Matrix	Microfibril Extracellular Region
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Fibronectin Binding Fibrinogen Binding
	Biological Process	Anatomical Structure Morphogenesis Extracellular Matrix Disassembly Extracellular Matrix Organization Embryonic Limb Morphogenesis Positive Regulation Of Bone Mineralization Sequestering Of TGFbeta In Extracellular Matrix Positive Regulation Of Osteoblast Differentiation Bone Trabecula Formation	Extracellular Matrix Organization Platelet Formation
Pathways		Molecules associated with elastic fibres Elastic fibre formation Degradation of the extracellular matrix	Molecules associated with elastic fibres Elastic fibre formation
Drugs
Diseases
GWAS		Height ( 21998595) Obesity (extreme) ( 19553259) Temperament ( 22832960)	Height ( 20881960 23563607) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		7 interactors: ELN FBN1 LTBP1 MATN2 MFAP2 MFAP5 SMAD2	5 interactors: BGN COL4A3 ELN FBN1 FBN2
Entrez ID		2201	4237
HPRD ID		00416	01137
Ensembl ID		ENSG00000138829	ENSG00000117122
Uniprot IDs		P35556	P55001
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Sequestering Of TGFbeta In Extracellular Matrix Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Extracellular Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of BMP Signaling Pathway Dendrite Regeneration Extracellular Matrix Disassembly Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Maintenance Of Protein Location Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Zygotic Specification Of Dorsal/ventral Axis Sequestering Of BMP In Extracellular Matrix Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Mesoderm Development Primary MiRNA Processing Regulation Of Nodal Signaling Pathway Common-partner SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway System Development Negative Regulation Of Signal Transduction Anatomical Structure Morphogenesis Extracellular Fibril Organization Kidney Development SMAD Protein Complex Assembly Negative Regulation Of Signaling Renal System Development Paraxial Mesoderm Morphogenesis Stress Fiber Assembly Multicellular Organismal Development Nodal Signaling Pathway Urogenital System Development Anatomical Structure Development Organ Development Production Of MiRNAs Involved In Gene Silencing By MiRNA Platelet Formation Embryonic Foregut Morphogenesis Platelet Morphogenesis Foregut Morphogenesis Regulation Of Activin Receptor Signaling Pathway Paraxial Mesoderm Development Response To Cholesterol Dorsal/ventral Axis Specification	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Sequestering Of TGFbeta In Extracellular Matrix Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction Blood Vessel Remodeling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Tissue Remodeling Maintenance Of Protein Location Regulation Of Cellular Response To Growth Factor Stimulus Endothelial Cell Apoptotic Process Sequestering Of BMP In Extracellular Matrix Organ Development Kidney Development Blood Circulation Renal System Development Dermatan Sulfate Biosynthetic Process Bone Trabecula Formation Urogenital System Development Dermatan Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Stress Fiber Assembly Glomerular Basement Membrane Development Bone Trabecula Morphogenesis System Development Chondroitin Sulfate Biosynthetic Process Skeletal System Development Chondroitin Sulfate Proteoglycan Biosynthetic Process Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Bone Mineralization Cell Proliferation Anatomical Structure Morphogenesis Positive Regulation Of Biomineral Tissue Development Negative Regulation Of BMP Signaling Pathway Peptide Cross-linking Trabecula Morphogenesis Developmental Process Respiratory Gaseous Exchange Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Metabolic Process Glomerulus Development Collagen Catabolic Process
Tagcloud ?		aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1	capturing clu elastic encompassing etiopathogenesis europeans extraocular fbn1 fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp snps tgm2 unrelated
Tagcloud (Difference) ?		aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c dmrta1 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae tt2 tt3 tt4 v1	capturing clu elastic encompassing etiopathogenesis europeans extraocular fbn1 fibrillar genotyped german glaucoma haplotypes intron italian likewise ltbp2 microfibrillopathy nominally nongenetic pex pexg pseudoexfoliation replicate rs2279590 snp tgm2 unrelated
Tagcloud (Intersection) ?		snps