FANCF and ICAM1

Data Source: HiPPIP (Novel)

		FANCF	ICAM1
Name		FA complementation group F	intercellular adhesion molecule 1
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Fanconi Anaemia Nuclear Complex	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	DNA Repair DNA Damage Response Interstrand Cross-link Repair	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Fanconi Anemia Pathway PKR-mediated signaling	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		None	Natalizumab Hyaluronic acid Nafamostat
Diseases		Fanconi anemia	Allograft rejection
GWAS		Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465 )	Blood protein levels ( 30072576 ) Crohn's disease ( 21102463 ) Height ( 31562340 ) Inflammatory bowel disease ( 23128233 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Low white blood cell count (conditioned on rs2814778) ( 29596498 ) Lymphocyte count ( 27863252 32888494 ) Monocyte count ( 32888494 ) Pulse pressure ( 27841878 ) Soluble ICAM-1 ( 18604267 21533024 31217265 ) White blood cell count ( 32888494 )
Interacting Genes		13 interacting genes: CTBP1 FAAP100 FAAP20 FANCA FANCB FANCC FANCE FANCG FANCL HES1 MARK3 OLFM2 TCP11	16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2
Entrez ID		2188	3383
HPRD ID		04589	00996
Ensembl ID		ENSG00000183161	ENSG00000090339
Uniprot IDs		A3KME0 Q9NPI8	A0A384MEK5 P05362
PDB IDs		2IQC 7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV	1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7
GO Terms Enriched among Interactors		Fanconi Anaemia Nuclear Complex Interstrand Cross-link Repair DNA Repair Chromatin DNA Metabolic Process DNA Damage Response Cellular Response To Stress Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription Corepressor Binding Ovarian Follicle Development Negative Regulation Of Pancreatic A Cell Differentiation N-box Binding Negative Regulation Of Cell Fate Determination Positive Regulation Of Mitotic Cell Cycle, Embryonic Trochlear Nerve Development Macromolecule Metabolic Process Response To Stress Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Oculomotor Nerve Development Cajal-Retzius Cell Differentiation Negative Regulation Of Forebrain Neuron Differentiation Hindbrain Morphogenesis Renal Interstitial Fibroblast Development Nucleus Cardiac Neural Crest Cell Development Involved In Outflow Tract Morphogenesis Regulation Of Timing Of Neuron Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Ureteric Bud Morphogenesis Negative Regulation Of Lymphoid Progenitor Cell Differentiation Negative Regulation Of Inner Ear Receptor Cell Differentiation Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Pro-B Cell Differentiation Regulation Of Mitotic Cell Cycle, Embryonic HLH Domain Binding Metanephric Nephron Tubule Morphogenesis Midbrain-hindbrain Boundary Morphogenesis Stomach Neuroendocrine Cell Differentiation Response To Aroclor 1254 Regulation Of Forebrain Neuron Differentiation Ascending Aorta Morphogenesis Lateral Inhibition Comma-shaped Body Morphogenesis T Cell Antigen Processing And Presentation Regulation Of Sperm Capacitation Notch Signaling Pathway	Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion