MYC and BCL2

Number of citations of the paper that reports this interaction (PMID 15210690)
27

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (in vitro)

		MYC	BCL2
Gene Name		v-myc avian myelocytomatosis viral oncogene homolog	B-cell CLL/lymphoma 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Protein Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Myelin Sheath Pore Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Complex Binding Protein Dimerization Activity Repressing Transcription Factor Binding E-box Binding	Protease Binding Protein Binding Transcription Factor Binding Channel Activity Channel Inhibitor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter MAPK Cascade Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Mesenchymal Cell Proliferation Energy Reserve Metabolic Process Chromatin Remodeling Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Cellular Iron Ion Homeostasis Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Positive Regulation Of Cell Proliferation Response To Gamma Radiation Gene Expression Regulation Of Gene Expression Oxygen Transport Regulation Of Telomere Maintenance Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To UV Cellular Response To Drug Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Epithelial Cell Proliferation Chromosome Organization Negative Regulation Of Cell Division Canonical Wnt Signaling Pathway Response To Growth Factor Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Response To DNA Damage Stimulus	Protein Polyubiquitination Ossification Ovarian Follicle Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response B Cell Homeostasis Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment Response To Ischemia Renal System Process Protein Dephosphorylation Melanin Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Humoral Immune Response Cellular Response To DNA Damage Stimulus Actin Filament Organization Axonogenesis Female Pregnancy Cell Aging Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Radiation Response To Toxic Substance Post-embryonic Development Response To Iron Ion Response To UV-B Response To Gamma Radiation Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cochlear Nucleus Development Gland Morphogenesis Regulation Of Transmembrane Transporter Activity Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Drug Response To Hydrogen Peroxide T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Spleen Development Thymus Development Digestive Tract Morphogenesis Developmental Growth Oocyte Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Organic Substance Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt Cyclin E associated events during G1/S transition binding of TCF/LEF:CTNNB1 to target gene promoters TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway RNF mutants show enhanced WNT signaling and proliferation G1/S Transition Signaling by NOTCH1 XAV939 inhibits tankyrase, stabilizing AXIN Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Mitotic G1-G1/S phases FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer S Phase Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer NOTCH1 Intracellular Domain Regulates Transcription Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex TCF dependent signaling in response to WNT Signaling by NOTCH1 PEST Domain Mutants in Cancer Cyclin A:Cdk2-associated events at S phase entry Signaling by WNT in cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer	Activation of BAD and translocation to mitochondria Inflammasomes The NLRP1 inflammasome Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Programmed Cell Death Activation of BH3-only proteins BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Innate Immune System Intrinsic Pathway for Apoptosis
Drugs			Ibuprofen Paclitaxel Docetaxel Rasagiline
Diseases
GWAS		Bladder cancer ( 20972438) Breast cancer ( 23535729) Colorectal cancer ( 23266556) Multiple sclerosis ( 21833088) Ovarian cancer ( 23535730 20852632) Urinary bladder cancer ( 20348956 18794855)	Cardiac Troponin-T levels ( 23247143)
Protein-Protein Interactions		126 interactors: ACTL6A ATAD2 AXIN1 BCL2 BIN1 BRCA1 BRD3 BTRC CCNH CCNT1 CDC6 CDCA7L CDK1 CDK4 CDK6 CDK8 CDKN2A CEBPA CEBPB CEP57 CREB1 CREBBP CSNK2A1 CSNK2A2 DNMT3A EFNB1 ELF3 EP300 EP400 FBXO8 FBXW7 FBXW8 GCN1L1 GPX2 GSK3A GSK3B GTF2B GTF2F1 GTF2I HNRNPD HSP90AA1 HUWE1 ING4 KAT2A KAT2B KAT5 KDM1A KIAA1524 KIDINS220 KPNA2 LDOC1 MAP2K1 MAPK1 MAPK3 MAPK7 MAPK8 MAX MED1 MED12 MED14 MED16 MEN1 MINA MLH1 MOK MXD1 MXI1 MYCBP MYCBP2 NEK11 NFYB NFYC NMI NOTCH3 NUCB1 PAK2 PARP10 PFDN5 PLAU PML POLR2A PRDX1 PSMC3 RAF1 RB1 RBL1 RELA RUVBL1 SAP130 SF3B1 SKP1 SKP2 SMAD2 SMAD3 SMARCA2 SMARCA4 SMARCB1 SMARCC1 SNIP1 SNRNP70 SP1 SPAG9 SUPT3H TADA2A TAF1B TAF5 TAF9 TBP TFAP2A TFAP2B TIAM1 TONSL TP73 TRIM6 TRRAP TUBA1A TUBA1B TUBA3C TUBA4A TUBA8 UBB USP37 YEATS4 YY1 ZBTB17 ZNF281	83 interactors: ATP2A2 BAD BAG1 BAG3 BAG4 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS EPHB2 FKBP8 HNRNPD HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPID PPP1CA PPP2CA PPP2R4 PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RRAS RTN4 SF1 SMN1 SOD1 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2
Entrez ID		4609	596
HPRD ID		01818	01045
Ensembl ID		ENSG00000136997	ENSG00000171791
Uniprot IDs		P01106	C9JHD5 P10415
PDB IDs		1A93 1EE4 1MV0 1NKP 2A93 2OR9	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4LXE
Enriched GO Terms of Interacting Partners?		Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Viral Process Regulation Of Cellular Process Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cell Cycle Negative Regulation Of Biosynthetic Process Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Gene Expression Cellular Response To Stress Mitotic Cell Cycle Histone Acetylation Negative Regulation Of Transcription, DNA-templated Chromatin Organization Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Regulation Of Cell Cycle Internal Protein Amino Acid Acetylation	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Death Negative Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Response To Growth Factor Signal Transduction Cell Communication Response To Abiotic Stimulus Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Intracellular Signal Transduction Apoptotic Mitochondrial Changes Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Response To Stress Regulation Of Catalytic Activity Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Permeability
Tagcloud ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast	adenocarcinomas anthracene carcinogenic chorionic dawley dimethylbenz dmba elevation exists glands gonadotropin hcg ice iu makes mammary modulated myc ovaries phenomenon probed programmed rnas sprague trpm2 virgin xl xs
Tagcloud (Difference) ?		augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks nmi potentiate recruitment reveal screen stat stat1 stat2 stat5 stat5b stats yeast	adenocarcinomas anthracene carcinogenic chorionic dawley dimethylbenz dmba elevation exists glands gonadotropin hcg ice iu makes mammary modulated ovaries phenomenon probed programmed rnas sprague trpm2 virgin xl xs
Tagcloud (Intersection) ?		myc