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MYC and RB1
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
55
Data Source:
BioGRID
(fluorescent resonance energy transfer)
HPRD
(in vivo)
MYC
RB1
Description
MYC proto-oncogene, bHLH transcription factor
RB transcriptional corepressor 1
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Nuclear Body
Axon
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Myc-Max Complex
RNA Polymerase II Transcription Repressor Complex
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Spindle
Cytosol
Cyclin/CDK Positive Transcription Elongation Factor Complex
SWI/SNF Complex
PML Body
Rb-E2F Complex
Chromatin Lock Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
Transcription Coregulator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein-containing Complex Binding
Protein Dimerization Activity
E-box Binding
DNA-binding Transcription Factor Binding
SCF Ubiquitin Ligase Complex Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
Transcription Corepressor Activity
Protein Binding
Enzyme Binding
Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Phosphoprotein Binding
Molecular Adaptor Activity
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Importin-alpha Family Protein Binding
Disordered Domain Specific Binding
DNA-binding Transcription Factor Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
B Cell Apoptotic Process
NK T Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of B Cell Apoptotic Process
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
DNA Damage Response
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Radiation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Regulation Of Cell Cycle Process
Positive Regulation Of Gene Expression
Myotube Differentiation
Wnt Signaling Pathway
RRNA Metabolic Process
Protein Processing
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Stress-activated MAPK Cascade
Protein-DNA Complex Disassembly
Cellular Response To UV
Cellular Response To Interferon-alpha
Skeletal Muscle Cell Differentiation
Middle Ear Morphogenesis
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Alkaloid
Pigmentation
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Fibroblast Apoptotic Process
Negative Regulation Of Monocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Skeletal System Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Chromosome Organization
Negative Regulation Of Cell Division
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Negative Regulation Of Transcription Initiation By RNA Polymerase II
ERK1 And ERK2 Cascade
Response To Growth Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of MiRNA Transcription
Regulation Of Somatic Stem Cell Population Maintenance
Positive Regulation Of Acinar Cell Proliferation
Acinar Cell Proliferation
Positive Regulation Of Apoptotic Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Growth
Tissue Homeostasis
Chondrocyte Differentiation
Aortic Valve Morphogenesis
Chromatin Organization
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Smoothened Signaling Pathway
Ras Protein Signal Transduction
Spermatogenesis
Regulation Of Mitotic Cell Cycle
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Glial Cell Proliferation
Cell Differentiation
Neuron Differentiation
Negative Regulation Of Cell Growth
Sister Chromatid Biorientation
Neuron Projection Development
Heterochromatin Formation
Developmental Process
Cellular Response To Insulin Stimulus
Maintenance Of Mitotic Sister Chromatid Cohesion
Glial Cell Apoptotic Process
Skeletal Muscle Cell Differentiation
Neuron Maturation
Enucleate Erythrocyte Differentiation
Regulation Of Lipid Kinase Activity
Myoblast Differentiation
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Cell Cycle
Positive Regulation Of Mitotic Metaphase/anaphase Transition
Negative Regulation Of Smoothened Signaling Pathway
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Digestive Tract Development
Cell Morphogenesis Involved In Neuron Differentiation
Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Inflammatory Response
Striated Muscle Cell Differentiation
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Regulation Of Cell Cycle
Negative Regulation Of Glial Cell Proliferation
Protein Localization To Chromosome, Centromeric Region
Cellular Response To Xenobiotic Stimulus
Regulation Of Centromere Complex Assembly
Hepatocyte Apoptotic Process
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Extracellular Matrix Organization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Collagen Fibril Organization
Negative Regulation Of Myofibroblast Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Transcription of E2F targets under negative control by DREAM complex
Signaling by ALK
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Binding of TCF/LEF:CTNNB1 to target gene promoters
MAPK6/MAPK4 signaling
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
TFAP2 (AP-2) family regulates transcription of cell cycle factors
RUNX3 regulates WNT signaling
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
Regulation of CDH1 mRNA translation by microRNAs
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Condensation of Prophase Chromosomes
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Oncogene Induced Senescence
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
RUNX2 regulates osteoblast differentiation
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Defective translocation of RB1 mutants to the nucleus
Replication of the SARS-CoV-1 genome
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Replication of the SARS-CoV-2 genome
Nuclear events stimulated by ALK signaling in cancer
Positive Regulation of CDH1 Gene Transcription
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Acetylsalicylic acid
Dimethyl sulfoxide
Doconexent
Nadroparin
Diseases
Penile cancer
Breast cancer
Laryngeal cancer
Oral cancer
Multiple myeloma
Kaposi's sarcoma
Ovarian cancer
Choriocarcinoma
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Burkitt lymphoma
Small cell lung cancer
Osteosarcoma
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Chronic myeloid leukemia (CML)
Breast cancer
Osteosarcoma
Hepatocellular carcinoma
Small cell lung cancer
Esophageal cancer
Glioma
Bladder cancer
GWAS
Alcohol use disorder (
30940813
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
23817571
)
Asthma (
34103634
32296059
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Bladder cancer (
20972438
)
Breast cancer (
29059683
23535729
)
Chronic lymphocytic leukemia (
23770605
)
Colorectal cancer (
24737748
25990418
26151821
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Diffuse large B cell lymphoma (
25261932
)
Endometrial cancer (
30093612
27135401
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometrial endometrioid carcinoma (
27135401
)
Glioblastoma (
29743610
)
Glioma (
29743610
)
Height (
25429064
)
Multiple sclerosis (
21833088
)
Non-glioblastoma glioma (
29743610
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Ovarian cancer (
20852632
23535730
)
Pancreatic cancer (
27579533
29422604
25086665
)
Prostate cancer (
24753544
)
Prostate cancer (early onset) (
24740154
)
Prostate-specific antigen levels (
28139693
)
Prostate-specific antigen levels (conditioned on lead SNPs) (
28139693
)
Renal cell carcinoma (
24220699
)
Serum alkaline phosphatase levels (
33547301
)
Urinary bladder cancer (
24861552
18794855
20348956
)
Birth weight (
27680694
31043758
)
Chronic kidney disease (
26420894
)
Diastolic blood pressure (
34074324
)
Lymphocyte count (
32888494
)
Offspring birth weight (
31043758
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Interacting Genes
182 interacting genes:
ACTL6A
AKT1
APP
ARAF
ARNT
ATAD2
ATG5
AURKA
AXIN1
BCL2
BIN1
BRCA1
BRD3
CBLC
CCAR2
CCNE1
CCNT1
CDC6
CDC73
CDCA7L
CDK1
CDK6
CDK8
CDKN1B
CDKN2A
CDKN2B
CDKN2C
CEBPA
CEBPB
CEP57
CHD8
CHUK
CIP2A
CREBBP
CSNK2A1
CSNK2A2
DACH1
DNMT3A
EFNB1
ELF3
ELP3
EP300
EP400
EPHA2
ERBB2
FBXO32
FBXO8
FBXW7
FBXW8
FGFR4
FZR1
GCN1
GLIS1
GLIS2
GPX2
GRM1
GSK3A
GSK3B
GTF2F1
GTF2I
HIF1A
HNRNPD
HSP90AA1
IKBKB
ING4
KAT2A
KAT2B
KAT5
KDELR2
KDM1A
KIDINS220
LATS2
LDOC1
MAP2K1
MAP2K5
MAPK1
MAPK14
MAPK3
MAPK7
MAPK8
MAX
MDM2
MED1
MED16
MEN1
MET
MLH1
MOK
MXD1
MXI1
MYCBP
MYCBP2
NDRG1
NEK11
NF2
NFIC
NFYB
NFYC
NMI
NONO
NOTCH3
NUCB1
OTUB1
PAK2
PARP10
PCGF6
PDGFRA
PFDN5
PIK3CA
PLAU
PLK1
PML
PPP2CA
PPP3R1
PRDX1
PSMC3
PTEN
RAF1
RASSF1
RB1
RBL1
RELA
RIOX2
SAP130
SENP2
SF3B1
SKP1
SKP2
SMAD2
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SNIP1
SNRNP70
SOX3
SOX4
SP1
SPAG9
STK11
SUPT3H
TADA2A
TAF12
TAF1B
TAF9
TBP
TEAD2
TERT
TFAP2A
TFAP2B
TIAM1
TONSL
TP53
TP73
TRIB3
TRIM6
TRIM63
TRIP12
TRRAP
TSC1
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
UBB
UBE3B
UBR5
USP1
USP2
USP36
USP37
USP45
USP7
VDR
WT1
YAF2
YBX1
YY1
ZBTB17
ZNF281
194 interacting genes:
AATF
ABL1
AHR
ANKS1A
AR
ARID3B
ATF2
BAAT
BAG1
BDP1
BNC2
BRCA1
BRF1
CASP10
CASP2
CASP3
CASP6
CASP7
CASP8
CASP9
CBX4
CCDC180
CCNA1
CCNA2
CCNB1
CCNC
CCND1
CCND2
CCND3
CCNE1
CCNT2
CDC27
CDK1
CDK14
CDK2
CDK3
CDK4
CDK5
CDK6
CDK9
CDKN1A
CDKN1C
CEBPA
CEBPB
CEBPD
CEBPE
CHEK1
CHN2
CLNK
CORO2A
CREG1
CTBP1
CTSV
CUX1
DGKZ
DNMT1
DVL1
DYRK1A
E2F1
E2F2
E2F3
E2F4
E4F1
EID1
ELF1
ENC1
EP300
FANCC
FBP1
FBP2
FOS
FOXM1
FRK
FZR1
GALNT12
GTF3C2
HBP1
HDAC1
HDAC3
HIF1A
HMGA2
HMGB1
HSPA8
ID2
INS
IRF3
JUN
KAT2B
KAT5
KDM4A
KDM5A
KDM5B
KEAP1
KMT5C
L3MBTL1
LEF1
LIN54
LIN9
LMNA
MAPK1
MAPK14
MAPK3
MAPK9
MCM7
MDM2
MDM4
MNAT1
MNDA
MORF4L1
MORF4L2
MRPS18B
MYC
MYOD1
NCF1
NCOA6
NDC80
NEFM
ORC1
PA2G4
PAX2
PAX5
PAX6
PELP1
PHB1
PIK3R1
PIK3R3
PLA2G12A
PML
POLA1
PPARG
PPIA
PPP1CA
PPP1CB
PPP1CC
PPP1R26
PPP1R9B
PRDM2
PRKCB
PRKRA
PRMT2
PSMD10
PURA
RABGAP1L
RACK1
RAF1
RASA1
RBAK
RBBP4
RBBP5
RBBP6
RBBP7
RBBP8
RBBP9
RING1
RINT1
RNF123
RNF40
RUNX2
SERPINB2
SHC1
SKP2
SMARCA4
SMARCB1
SMYD2
SNAPC1
SNAPC3
SNW1
SP1
SP3
SPI1
SPIB
STAT3
STX17
SUV39H1
TAF1
TASOR
TBP
TFAP2A
TGM2
THOC1
TMPO
TOP2A
TRAP1
TRIM27
TRIM28
TRIP11
TRMO
UBE2I
UBTF
USP4
USP7
VDR
XPA
ZBTB16
Entrez ID
4609
5925
HPRD ID
01818
01574
Ensembl ID
ENSG00000136997
ENSG00000139687
Uniprot IDs
P01106
A0A2R8YFL6
A0A3B3IS71
P06400
PDB IDs
1A93
1EE4
1MV0
1NKP
2A93
2OR9
4Y7R
5I4Z
5I50
6C4U
6E16
6E24
6G6J
6G6K
6G6L
7T1Y
7T1Z
8J2Q
8OTS
8OTT
8Q1N
8WLG
8X8S
8X8V
1AD6
1GH6
1GUX
1H25
1N4M
1O9K
1PJM
2AZE
2QDJ
2R7G
3N5U
3POM
4CRI
4ELJ
4ELL
9DGK
9DHC
9DHF
9DHU
Enriched GO Terms of Interacting Partners
?
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Nucleoplasm
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cell Population Proliferation
Cellular Response To Stress
Regulation Of Cellular Response To Stress
Regulation Of DNA Metabolic Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Regulation Of Apoptotic Process
DNA-binding Transcription Factor Binding
Regulation Of Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Chromatin Organization
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Stability
Protein Modification Process
Regulation Of Protein Modification Process
Chromatin Binding
Nucleoplasm
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Nucleus
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Biosynthetic Process
Cellular Response To Stress
Regulation Of Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
DNA Damage Response
Chromatin
Chromatin Binding
Positive Regulation Of Transcription By RNA Polymerase II
Nucleic Acid Metabolic Process
Regulation Of Cell Population Proliferation
Regulation Of Programmed Cell Death
DNA-templated Transcription
Regulation Of Apoptotic Process
Macromolecule Metabolic Process
Chromatin Remodeling
Chromatin Organization
Regulation Of Mitotic Cell Cycle
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Intracellular Signal Transduction
DNA Binding
Transcription Cis-regulatory Region Binding
Nucleobase-containing Compound Metabolic Process
Response To Stress
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