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MYC and AURKA
Number of citations of the paper that reports this interaction (PubMedID
28205554
)
55
Data Source:
BioGRID
(fluorescent resonance energy transfer, proximity labelling technology)
MYC
AURKA
Description
MYC proto-oncogene, bHLH transcription factor
aurora kinase A
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Spindle
Nuclear Body
Axon
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Myc-Max Complex
RNA Polymerase II Transcription Repressor Complex
Kinetochore
Spindle Pole
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Centriole
Microtubule Organizing Center
Spindle
Cytosol
Cytoskeleton
Microtubule
Spindle Microtubule
Plasma Membrane
Cilium
Postsynaptic Density
Microtubule Cytoskeleton
Membrane
Basolateral Plasma Membrane
Midbody
Spindle Pole Centrosome
Chromosome Passenger Complex
Ciliary Basal Body
Germinal Vesicle
Cell Projection
Neuron Projection
Axon Hillock
Pronucleus
Perinuclear Region Of Cytoplasm
Spindle Midzone
Mitotic Spindle
Meiotic Spindle
Mitotic Spindle Pole
Glutamatergic Synapse
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
Core Promoter Sequence-specific DNA Binding
Transcription Coregulator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein-containing Complex Binding
Protein Dimerization Activity
E-box Binding
DNA-binding Transcription Factor Binding
SCF Ubiquitin Ligase Complex Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Histone H3S10 Kinase Activity
Protein Heterodimerization Activity
Protein Serine Kinase Activity
Molecular Function Activator Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Branching Involved In Ureteric Bud Morphogenesis
B Cell Apoptotic Process
NK T Cell Proliferation
Positive Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of B Cell Apoptotic Process
Chromatin Remodeling
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Transcription By RNA Polymerase II
Intracellular Iron Ion Homeostasis
DNA Damage Response
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Radiation
Response To Xenobiotic Stimulus
Regulation Of Gene Expression
Regulation Of Cell Cycle Process
Positive Regulation Of Gene Expression
Myotube Differentiation
Wnt Signaling Pathway
RRNA Metabolic Process
Protein Processing
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Stress-activated MAPK Cascade
Protein-DNA Complex Disassembly
Cellular Response To UV
Cellular Response To Interferon-alpha
Skeletal Muscle Cell Differentiation
Middle Ear Morphogenesis
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Alkaloid
Pigmentation
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Fibroblast Apoptotic Process
Negative Regulation Of Monocyte Differentiation
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Negative Regulation Of Fibroblast Proliferation
Skeletal System Morphogenesis
Positive Regulation Of Epithelial Cell Proliferation
Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound
Chromosome Organization
Negative Regulation Of Cell Division
Positive Regulation Of Transcription Initiation By RNA Polymerase II
Negative Regulation Of Transcription Initiation By RNA Polymerase II
ERK1 And ERK2 Cascade
Response To Growth Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of MiRNA Transcription
Regulation Of Somatic Stem Cell Population Maintenance
Positive Regulation Of Acinar Cell Proliferation
Acinar Cell Proliferation
Positive Regulation Of Apoptotic Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Meiotic Spindle Organization
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Chromatin Remodeling
Protein Phosphorylation
Apoptotic Process
Spindle Organization
Mitotic Spindle Organization
Spindle Assembly Involved In Female Meiosis I
Centrosome Cycle
Mitotic Centrosome Separation
Response To Wounding
Anterior/posterior Axis Specification
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Gene Expression
Peptidyl-serine Phosphorylation
Cell Projection Organization
Regulation Of Protein Stability
Negative Regulation Of Protein Binding
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Regulation Of Microtubule-based Process
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cell Cycle G2/M Phase Transition
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Centrosome Cycle
Protein Autophosphorylation
Cell Division
Meiotic Cell Cycle
Centrosome Localization
Cilium Disassembly
Protein Localization To Centrosome
Positive Regulation Of Cell Cycle Process
Positive Regulation Of Mitochondrial Fission
Liver Regeneration
Positive Regulation Of Oocyte Maturation
Regulation Of Signal Transduction By P53 Class Mediator
Neuron Projection Extension
Pathways
Transcription of E2F targets under negative control by DREAM complex
Signaling by ALK
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Binding of TCF/LEF:CTNNB1 to target gene promoters
MAPK6/MAPK4 signaling
Ub-specific processing proteases
Interleukin-4 and Interleukin-13 signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
TFAP2 (AP-2) family regulates transcription of cell cycle factors
RUNX3 regulates WNT signaling
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
Regulation of CDH1 mRNA translation by microRNAs
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M Transition
SUMOylation of DNA replication proteins
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
AURKA Activation by TPX2
Interaction between PHLDA1 and AURKA
Drugs
Acetylsalicylic acid
Dimethyl sulfoxide
Doconexent
Nadroparin
Phosphonothreonine
AT9283
CYC116
Alisertib
SNS-314
Cenisertib
Enzastaurin
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
AKI-001
1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea
1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea
N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE
N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide
2-(1H-pyrazol-3-yl)-1H-benzimidazole
N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE
Fostamatinib
MK-5108
MLN8054
Diseases
Penile cancer
Breast cancer
Laryngeal cancer
Oral cancer
Multiple myeloma
Kaposi's sarcoma
Ovarian cancer
Choriocarcinoma
Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
Burkitt lymphoma
Small cell lung cancer
Osteosarcoma
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Alcohol use disorder (
30940813
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
30013184
)
Allergic sensitization (
23817571
)
Asthma (
34103634
32296059
30929738
)
Asthma (childhood onset) (
31036433
30929738
)
Bladder cancer (
20972438
)
Breast cancer (
29059683
23535729
)
Chronic lymphocytic leukemia (
23770605
)
Colorectal cancer (
24737748
25990418
26151821
23266556
)
Colorectal cancer or advanced adenoma (
30510241
)
Diffuse large B cell lymphoma (
25261932
)
Endometrial cancer (
30093612
27135401
)
Endometrial cancer (endometrioid histology) (
30093612
)
Endometrial endometrioid carcinoma (
27135401
)
Glioblastoma (
29743610
)
Glioma (
29743610
)
Height (
25429064
)
Multiple sclerosis (
21833088
)
Non-glioblastoma glioma (
29743610
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Ovarian cancer (
20852632
23535730
)
Pancreatic cancer (
27579533
29422604
25086665
)
Prostate cancer (
24753544
)
Prostate cancer (early onset) (
24740154
)
Prostate-specific antigen levels (
28139693
)
Prostate-specific antigen levels (conditioned on lead SNPs) (
28139693
)
Renal cell carcinoma (
24220699
)
Serum alkaline phosphatase levels (
33547301
)
Urinary bladder cancer (
24861552
18794855
20348956
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
182 interacting genes:
ACTL6A
AKT1
APP
ARAF
ARNT
ATAD2
ATG5
AURKA
AXIN1
BCL2
BIN1
BRCA1
BRD3
CBLC
CCAR2
CCNE1
CCNT1
CDC6
CDC73
CDCA7L
CDK1
CDK6
CDK8
CDKN1B
CDKN2A
CDKN2B
CDKN2C
CEBPA
CEBPB
CEP57
CHD8
CHUK
CIP2A
CREBBP
CSNK2A1
CSNK2A2
DACH1
DNMT3A
EFNB1
ELF3
ELP3
EP300
EP400
EPHA2
ERBB2
FBXO32
FBXO8
FBXW7
FBXW8
FGFR4
FZR1
GCN1
GLIS1
GLIS2
GPX2
GRM1
GSK3A
GSK3B
GTF2F1
GTF2I
HIF1A
HNRNPD
HSP90AA1
IKBKB
ING4
KAT2A
KAT2B
KAT5
KDELR2
KDM1A
KIDINS220
LATS2
LDOC1
MAP2K1
MAP2K5
MAPK1
MAPK14
MAPK3
MAPK7
MAPK8
MAX
MDM2
MED1
MED16
MEN1
MET
MLH1
MOK
MXD1
MXI1
MYCBP
MYCBP2
NDRG1
NEK11
NF2
NFIC
NFYB
NFYC
NMI
NONO
NOTCH3
NUCB1
OTUB1
PAK2
PARP10
PCGF6
PDGFRA
PFDN5
PIK3CA
PLAU
PLK1
PML
PPP2CA
PPP3R1
PRDX1
PSMC3
PTEN
RAF1
RASSF1
RB1
RBL1
RELA
RIOX2
SAP130
SENP2
SF3B1
SKP1
SKP2
SMAD2
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SNIP1
SNRNP70
SOX3
SOX4
SP1
SPAG9
STK11
SUPT3H
TADA2A
TAF12
TAF1B
TAF9
TBP
TEAD2
TERT
TFAP2A
TFAP2B
TIAM1
TONSL
TP53
TP73
TRIB3
TRIM6
TRIM63
TRIP12
TRRAP
TSC1
TUBA1A
TUBA1B
TUBA3C
TUBA4A
TUBA8
UBB
UBE3B
UBR5
USP1
USP2
USP36
USP37
USP45
USP7
VDR
WT1
YAF2
YBX1
YY1
ZBTB17
ZNF281
171 interacting genes:
AATF
AJUBA
AKT1
ANGPTL4
ANP32B
APP
ARPC1B
ARPC2
ATRX
AUNIP
AURKAIP1
BAAT
BCL2L1
BEX2
BIRC5
BLID
BORA
BRAF
BRCA1
BTK
CBX3
CCND2
CCNE1
CDC20
CDC25B
CDH13
CDK8
CEBPA
CHFR
CKAP5
CORO2A
CPEB1
CSN2
CTCFL
CYLC2
DACH1
DKK3
EHMT2
EPHA2
EPSTI1
ERBB2
ERRFI1
FANCA
FBP2
FOXF1
FOXP1
GADD45A
GMNN
GSK3B
GTF3C4
H3-4
H3C1
HDAC2
HEMGN
HIF1A
HNRNPF
HNRNPK
IFI16
IGFBP3
IKBKB
KIF11
KIF2C
KLHL18
KLK5
LATS2
LEF1
LYPD3
MAP2K1
MAP2K3
MAP3K5
MAPK3
MAPRE2
MAPRE3
MBD3
MBP
MDM2
MED26
MTA3
MYC
MYT1
MYT1L
NANS
NAT2
NDC80
NEDD9
NF2
NFKBIA
NFXL1
NIN
NKX1-1
NME1
NSD2
NUF2
OLA1
OTUB1
PARP10
PAX4
PAX8
PDGFRA
PDLIM2
PLK3
PML
POU4F3
PPP1CA
PPP1CB
PPP1CC
PPP3R2
PPP6C
PRKACA
PSEN2
PSMC3IP
PSRC1
PTPRD
PTTG1
PUM2
RASA1
RASSF1
RELA
REST
S100A14
SCGB3A1
SEC61B
SFRP4
SIN3B
SOX18
SOX3
SOX30
SOX4
SREBF2
SRPK1
SRPK2
SSRP1
STAT2
STK11
STX17
SUPT20H
SWT1
TACC1
TACC3
TBC1D2
TBX10
TCEAL2
TCERG1
TCF3
TEAD2
TFAP2B
TGFB1
THRSP
TLK1
TLK2
TP53
TP73
TPX2
TRMO
TRRAP
TSC1
TSTD2
UBE2C
UBE2I
UBE2N
UBTF
USP2
USP21
VHL
WIF1
XPA
YY1
ZFHX3
ZKSCAN2
ZNF189
ZNF510
Entrez ID
4609
6790
HPRD ID
01818
04066
Ensembl ID
ENSG00000136997
ENSG00000087586
Uniprot IDs
P01106
O14965
PDB IDs
1A93
1EE4
1MV0
1NKP
2A93
2OR9
4Y7R
5I4Z
5I50
6C4U
6E16
6E24
6G6J
6G6K
6G6L
7T1Y
7T1Z
8J2Q
8OTS
8OTT
8Q1N
8WLG
8X8S
8X8V
1MQ4
1MUO
1OL5
1OL6
1OL7
2BMC
2C6D
2C6E
2DWB
2J4Z
2J50
2NP8
2W1C
2W1D
2W1E
2W1F
2W1G
2WQE
2WTV
2WTW
2X6D
2X6E
2X81
2XNE
2XNG
2XRU
3COH
3E5A
3EFW
3FDN
3H0Y
3H0Z
3H10
3HA6
3K5U
3LAU
3M11
3MYG
3NRM
3O50
3O51
3P9J
3QBN
3R21
3R22
3UNZ
3UO4
3UO5
3UO6
3UOD
3UOH
3UOJ
3UOK
3UOL
3UP2
3UP7
3VAP
3W10
3W16
3W18
3W2C
4B0G
4BN1
4BYI
4BYJ
4C3P
4C3R
4CEG
4DEA
4DEB
4DED
4DEE
4DHF
4J8M
4J8N
4JAI
4JAJ
4JBO
4JBP
4JBQ
4O0S
4O0U
4O0W
4PRJ
4UYN
4UZD
4UZH
4ZS0
4ZTQ
4ZTR
4ZTS
5AAD
5AAE
5AAF
5AAG
5DN3
5DNR
5DOS
5DPV
5DR2
5DR6
5DR9
5DRD
5DT0
5DT3
5DT4
5EW9
5G15
5G1X
5L8J
5L8K
5L8L
5LXM
5OBJ
5OBR
5ODT
5ONE
5ORL
5ORN
5ORO
5ORP
5ORR
5ORS
5ORT
5ORV
5ORW
5ORX
5ORY
5ORZ
5OS0
5OS1
5OS2
5OS3
5OS4
5OS5
5OS6
5OSD
5OSE
5OSF
5ZAN
6C2R
6C2T
6C83
6CPE
6CPF
6CPG
6GRA
6HJJ
6HJK
6I2U
6R49
6R4A
6R4B
6R4C
6R4D
6VPG
6VPH
6VPI
6VPJ
6VPL
6VPM
6XKA
6Z4Y
7AYH
7AYI
7FIC
7O2V
7ZTL
8C14
8C15
8C1D
8C1E
8C1F
8C1G
8C1H
8C1I
8C1K
8C1M
8GUW
8JF4
8JG8
8JMX
8OF5
8PR7
8SSO
8SSP
9BZG
9BZL
Enriched GO Terms of Interacting Partners
?
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of Macromolecule Metabolic Process
Regulation Of DNA-templated Transcription
Nucleoplasm
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cell Population Proliferation
Cellular Response To Stress
Regulation Of Cellular Response To Stress
Regulation Of DNA Metabolic Process
Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Regulation Of Apoptotic Process
DNA-binding Transcription Factor Binding
Regulation Of Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Regulation Of Developmental Process
Regulation Of Cell Differentiation
Chromatin Organization
Regulation Of Cell Cycle Phase Transition
Regulation Of Protein Stability
Protein Modification Process
Regulation Of Protein Modification Process
Chromatin Binding
Nucleus
Regulation Of Primary Metabolic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Intracellular Signal Transduction
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Cell Division
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Differentiation
Regulation Of Developmental Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Population Proliferation
Chromatin
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Response To Radiation
Regulation Of Mitotic Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Cellular Component Organization
DNA-binding Transcription Factor Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Cellular Response To Stress
Cytoplasm
Regulation Of Signal Transduction
Anatomical Structure Morphogenesis
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