ARRB1 and PTAFR

Number of citations of the paper that reports this interaction (PMID 16709866)
23

Data Source:
BioGRID (affinity chromatography technology, fluorescent resonance energy transfer)

		ARRB1	PTAFR
Gene Name		arrestin, beta 1	platelet-activating factor receptor
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Cytosol Heterotrimeric G-protein Complex Plasma Membrane Coated Pit Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Angiotensin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity G-protein Coupled Receptor Activity Platelet Activating Factor Receptor Activity Phospholipid Binding G-protein Coupled Purinergic Nucleotide Receptor Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation G-protein Coupled Receptor Internalization Positive Regulation Of Receptor Internalization Transcription From RNA Polymerase II Promoter Post-Golgi Vesicle-mediated Transport Notch Signaling Pathway Blood Coagulation Phototransduction Protein Transport Protein Ubiquitination Platelet Activation Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Stress Fiber Assembly Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation	Cytokine Production Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Interferon-gamma-mediated Signaling Pathway
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Golgi Associated Vesicle Biogenesis Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Hedgehog 'on' state Signaling by NOTCH1 Signaling by Hedgehog Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Platelet activation, signaling and aggregation trans-Golgi Network Vesicle Budding FBXW7 Mutants and NOTCH1 in Cancer Activation of SMO	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Interferon Signaling Cytokine Signaling in Immune system Metabolic disorders of biological oxidation enzymes GPCR ligand binding Interferon gamma signaling G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		52 interactors: ADH6 ADRB1 ADRB2 ADRBK1 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 PTAFR PTH1R PTHLH RALGDS RPL15 SLC9A5 SREBF2 STAM TRHR ZBTB43	9 interactors: ARR3 ARRB1 ARRB2 CALM1 GORAB GTPBP3 RGS4 SPATA24 TYK2
Entrez ID		408	5724
HPRD ID		00146	01422
Ensembl ID		ENSG00000137486	ENSG00000169403
Uniprot IDs		B7Z1Q3 P49407	A8K7N8 P25105
PDB IDs		2IV8	2B0X
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Signal Transduction Signaling Cell Communication Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune Response Innate Immune Response Innate Immune Response-activating Signal Transduction Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Immune Response Intracellular Signal Transduction Defense Response Activation Of Innate Immune Response Regulation Of Signal Transduction Positive Regulation Of Immune System Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling Immune System Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune System Process Response To Stimulus Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Cellular Metabolic Process Pattern Recognition Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway Regulation Of Protein Phosphorylation Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Internalization Regulation Of Protein Phosphorylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Detection Of Abiotic Stimulus Regulation Of Phosphorylation Platelet Activation Regulation Of Receptor Internalization Regulation Of Phosphorus Metabolic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Receptor Internalization Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Calcium Ion Transport Phototransduction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Detection Of Light Stimulus Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Detection Of Stimulus Regulation Of Body Fluid Levels Vesicle-mediated Transport Positive Regulation Of ERK1 And ERK2 Cascade Wound Healing Regulation Of MAPK Cascade Regulation Of Signal Transduction Notch Signaling Pathway Regulation Of Protein Binding Endocytosis Cell Activation Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?		11q13 adrenergic apparently ark ark1 arrestin beta chromosome coding cofactor color consisting coupled desensitization determining far fish functionally grk homologous kinases localized map mapping member multigene named occupied phosphorylates	10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?