PTAFR

Gene Name		platelet-activating factor receptor
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Receptor Activity G-protein Coupled Receptor Activity Platelet Activating Factor Receptor Activity Phospholipid Binding G-protein Coupled Purinergic Nucleotide Receptor Activity
	Biological Process	Cytokine Production Chemotaxis Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Inositol Trisphosphate Biosynthetic Process G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Interferon-gamma-mediated Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Interferon Signaling Cytokine Signaling in Immune system Metabolic disorders of biological oxidation enzymes GPCR ligand binding Interferon gamma signaling G alpha (q) signalling events GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: ARR3 ARRB1 ARRB2 CALM1 GORAB GTPBP3 RGS4 SPATA24 TYK2
Entrez ID		5724
HPRD ID		01422
Ensembl ID		ENSG00000169403
Uniprot IDs		A8K7N8 P25105
PDB IDs		2B0X
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Internalization Regulation Of Protein Phosphorylation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Receptor Internalization Detection Of Abiotic Stimulus Regulation Of Phosphorylation Platelet Activation Regulation Of Receptor Internalization Regulation Of Phosphorus Metabolic Process Negative Regulation Of Interleukin-6 Production Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Cellular Protein Metabolic Process Receptor Internalization Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Receptor Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Calcium Ion Transport Phototransduction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Interleukin-6 Production Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Endocytosis Detection Of Light Stimulus Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Detection Of Stimulus Regulation Of Body Fluid Levels Vesicle-mediated Transport Positive Regulation Of ERK1 And ERK2 Cascade Wound Healing Regulation Of MAPK Cascade Regulation Of Signal Transduction Notch Signaling Pathway Regulation Of Protein Binding Endocytosis Cell Activation Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		10d a2a adenosine adora1 adora2a adora3 b4 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene ltb4r mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl purinergic sell selplg slc29a1 slc29a2