PTAFR and RGS4

Number of citations of the paper that reports this interaction (PubMedID 11297424)
0

Data Source:
HPRD (in vitro)

		PTAFR	RGS4
Description		platelet activating factor receptor	regulator of G protein signaling 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Secretory Granule Membrane Tertiary Granule Membrane	Nucleus Cytoplasm Plasma Membrane Protein-containing Complex
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding Protein Kinase Binding
	Biological Process	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway	Response To Amphetamine G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Heart Rate Response To Cocaine Response To Ethanol Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Calcium Ion Transport Negative Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Actin Filament Organization Negative Regulation Of Glycine Import Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Potassium Ion Transmembrane Transport Dorsal Root Ganglion Development Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs		Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825)	Daytime nap ( 33568662) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mTOR inhibitor (rapamycin) ( 24009623)
Interacting Genes		19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SLC33A2 SPATA24 TMEM120A TMX2 TYK2	15 interacting genes: CALM1 COPB1 COPB2 EGFR ERBB3 GABBR1 GNAI1 GNAI2 GNAO1 GNAQ KCMF1 KRIT1 PLCB1 PTAFR UBR1
Entrez ID		5724	5999
HPRD ID		01422	03947
Ensembl ID		ENSG00000169403	ENSG00000117152
Uniprot IDs		A8K7N8 P25105	P49798
PDB IDs		5ZKP 5ZKQ 8XYD
Enriched GO Terms of Interacting Partners?		Myelin Sheath Compact Myelin G Protein-coupled Receptor Internalization Modulation Of Chemical Synaptic Transmission Regulation Of Calcium Ion Transport Regulation Of Monoatomic Cation Transmembrane Transport Structural Constituent Of Myelin Sheath Myelination Axon Ensheathment Regulation Of Monoatomic Ion Transmembrane Transport Protein Heterooligomerization Positive Regulation Of Synaptic Transmission Regulation Of Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Positive Regulation Of Excitatory Postsynaptic Potential Response To Interferon-beta Positive Regulation Of Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Substantia Nigra Development Regulation Of Monoatomic Ion Transport Terminal Bouton Propylene Metabolic Process Positive Regulation Of Metalloendopeptidase Activity Type 8 Metabotropic Glutamate Receptor Binding Response To Virus Regulation Of Membrane Potential Positive Regulation Of Receptor Signaling Pathway Via STAT Calmodulin Binding Modulation Of Excitatory Postsynaptic Potential Regulation Of Synaptic Plasticity Cellular Response To Amyloid-beta Angiotensin Receptor Binding Positive Regulation Of Cell Communication Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Excitatory Postsynaptic Potential Intracellular Signal Transduction Positive Regulation Of Signaling Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Response To Glycine Response To Amyloid-beta Negative Regulation Of Glycine Import Across Plasma Membrane Type I Interferon-mediated Signaling Pathway Regulation Of Transcytosis TRNA 5-taurinomethyluridine Synthase Activity Mitochondrial TRNA Wobble Uridine Modification Nervous System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Potassium Ion Transmembrane Transport	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Secretion G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Positive Regulation Of Mitotic Cell Cycle Phase Transition Adenylate Cyclase Regulator Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Plasma Membrane Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Signaling Pathway Inositol Trisphosphate Metabolic Process Postsynaptic Signal Transduction Negative Regulation Of Secretion By Cell Regulation Of G1/S Transition Of Mitotic Cell Cycle Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Signaling Pathway COPI Vesicle Coat Receptor Complex Regulation Of Secretion Regulation Of Peptide Hormone Secretion G Protein-coupled Receptor Binding G Protein Activity Membrane COPI-coated Vesicle Membrane Protein Tyrosine Kinase Activator Activity Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle Process GABA-ergic Synapse Positive Regulation Of Cell Cycle Process Regulation Of Hormone Secretion Purinergic Nucleotide Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission ERBB2 Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Prostaglandin E Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inositol Phosphate Metabolic Process Membrane Coat Protein Tyrosine Kinase Activity
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