JUN and STAT3

Number of citations of the paper that reports this interaction (PMID 10490649)
41

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		JUN	STAT3
Gene Name		jun proto-oncogene	signal transducer and activator of transcription 3 (acute-phase response factor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytosol Transcriptional Repressor Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrial Inner Membrane Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Rho GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding R-SMAD Binding HMG Box Domain Binding	RNA Polymerase II Repressing Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Phosphatase Binding CCR5 Chemokine Receptor Binding Glucocorticoid Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Dimerization Activity
	Biological Process	Angiogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Liver Development Positive Regulation Of Endothelial Cell Proliferation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Aging Learning Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Response To Mechanical Stimulus Monocyte Differentiation Axon Regeneration Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Rho GTPase Activity Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Leading Edge Cell Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Response To Hydrogen Peroxide Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Innate Immune Response Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Potassium Ion Starvation Stress-activated MAPK Cascade Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Negative Regulation Of Transcription From RNA Polymerase II Promoter Temperature Homeostasis Eye Photoreceptor Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Protein Import Into Nucleus Movement Of Cell Or Subcellular Component Acute-phase Response Signal Transduction JAK-STAT Cascade Nervous System Development Cell Proliferation Negative Regulation Of Cell Proliferation Viral Process Phosphorylation Cytokine-mediated Signaling Pathway Sexual Reproduction Intracellular Receptor Signaling Pathway Response To Estradiol Cellular Response To Hormone Stimulus Somatic Stem Cell Maintenance Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Eating Behavior Response To Ethanol Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Astrocyte Differentiation Radial Glial Cell Differentiation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Negative Regulation Of Cell Death Interleukin-6-mediated Signaling Pathway Negative Regulation Of Neuron Migration
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Pre-NOTCH Transcription and Translation MyD88 dependent cascade initiated on endosome Pre-NOTCH Expression and Processing TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases	Signaling by PDGF Signalling by NGF Signaling by FGFR in disease Cellular Senescence Interleukin-6 signaling Senescence-Associated Secretory Phenotype (SASP) Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Signaling by SCF-KIT Signaling by Interleukins Transcriptional regulation of pluripotent stem cells Downstream signal transduction Signaling by FGFR1 mutants Signalling to STAT3 Signaling by FGFR mutants Signaling by FGFR1 fusion mutants POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Leptin Growth hormone receptor signaling
Drugs		Vinblastine Irbesartan Arsenic trioxide
Diseases
GWAS		Cognitive performance ( 19734545)	Crohn's disease ( 18587394 21102463 23266558) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 21833088 20159113)
Protein-Protein Interactions		185 interactors: ABL1 APLP2 APP AR ARRB1 ASCC1 ASCC2 ASCC3 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BATF3 BBS7 BCL3 BCL6 BRCA1 CASP9 CEBPE CEBPG CLINT1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CREB3 CREB5 CREBBP CSNK2A1 CSNK2A2 CSNK2B DACH1 DDIT3 DDX21 DHX9 EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GOPC GPS1 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFATC2 NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RFWD2 RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBE2I VAV1 VDR	161 interactors: ADRB2 AMBP AR ARFIP2 ASXL1 BCKDK BHLHE40 BICD1 BLK BMX BRCA1 CAPN1 CAPNS1 CCND1 CCR1 CCR5 CDK9 CDKN1A CEP120 CORO1A CREBBP CSF2RB CSF3R CXCR4 DAXX ECH1 EGFR EIF2AK2 ELP2 EP300 EPHA3 ERBB2 ERBB2IP FER FES FGFR3 FGFR4 FGR FHL2 FLT1 FOXM1 FYN GATA1 GATA2 GHR GNB2L1 GNL3 GTF2I HCK HDAC1 HDAC2 HDAC3 HES1 HES5 HIC1 HIF1A HIVEP1 HLA-A HNF1A HNRNPM HOXC11 HSP90AA1 HSP90AB1 IFNAR1 IFNAR2 IGF1R IL1RAP IL22RA1 IL23R IL2RA IL2RB IL6R IL6ST IL7R IRAK1 JAK1 JAK2 JAK3 JUN KAT5 KDM1A KHDRBS1 KPNA1 KPNA6 LAMB2 LCK LEP LEPR LMO2 LYN MAP3K13 MAP3K7 MAPK1 MAPK3 MAPK8 MET MORC4 MRPS31 MTOR MYOD1 NCOA1 NDUFA13 NFKB1 NFKBIZ NIF3L1 NLK NMI NR3C1 NR4A1 OGDHL PCBD2 PDGFRA PDGFRB PDIA3 PELP1 PIAS3 PML PRKCD PTK2B PTMA PTPN1 PTPN11 PTPN2 RAC1 RB1 RELA RET RPA2 RPL11 RPS6KA5 RPS9 SCAF11 SETD7 SIAH1 SIAH2 SIN3A SMARCA4 SPRY1 SRC SRI SRRT SS18L1 SSSCA1 STAP2 STAT1 STAT4 STAT5A STAT5B STAT6 STMN1 SULT2A1 SUMO4 SUPT20H SYK TRIM28 TRIP10 TSHR TSLP ZFPM2 ZNF148 ZNF467
Entrez ID		3725	6774
HPRD ID		01302	00026
Ensembl ID		ENSG00000177606	ENSG00000168610
Uniprot IDs		P05412	K7ENL3 P40763
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Cellular Response To Stress Cell Differentiation Multicellular Organismal Development Response To Organic Substance Anatomical Structure Development Response To Stress Organ Development Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance System Development DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter	Cellular Response To Organic Substance Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Defense Response Response To Cytokine Regulation Of Signal Transduction Immune System Process Regulation Of Nitrogen Compound Metabolic Process Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Cell Communication Signaling Positive Regulation Of Gene Expression Response To Stress Response To Stimulus Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Regulation Of Immune Response Immune Response Protein Autophosphorylation Regulation Of Protein Metabolic Process Regulation Of Cellular Process Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Peptidyl-amino Acid Modification Positive Regulation Of Cell Proliferation Positive Regulation Of Immune System Process Regulation Of Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Positive Regulation Of Signal Transduction Intracellular Signal Transduction Response To External Stimulus Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation
Tagcloud ?		acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus jun mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Difference) ?		acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield	1r a25 ang angiotensin at1 bfgf cho constructs dependently dominant fibroblast ikappabalpha janus mek mek1 messengers modulators overexpress pathophysiological raf ras redox shared stat1 stimulatory transcriptionally transfection transiently tyrphostin
Tagcloud (Intersection) ?		jun