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JUN and SUMO2
Number of citations of the paper that reports this interaction (PubMedID
16620772
)
0
Data Source:
HPRD
(in vivo)
JUN
SUMO2
Description
Jun proto-oncogene, AP-1 transcription factor subunit
small ubiquitin like modifier 2
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromatin
Euchromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Transcription Repressor Complex
Transcription Factor AP-1 Complex
RNA Polymerase II Transcription Regulator Complex
Nucleus
Nucleoplasm
PML Body
Hippocampal Mossy Fiber To CA3 Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
GABA-ergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
GTPase Activator Activity
Protein Binding
Enzyme Binding
Ubiquitin Protein Ligase Binding
CAMP Response Element Binding
Identical Protein Binding
Ubiquitin-like Protein Ligase Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
R-SMAD Binding
General Transcription Initiation Factor Binding
Sequence-specific Double-stranded DNA Binding
RNA Binding
Protein Binding
SUMO Transferase Activity
Protein Tag Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-like Protein Ligase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Microglial Cell Activation
Liver Development
Positive Regulation Of Endothelial Cell Proliferation
Outflow Tract Morphogenesis
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
JNK Cascade
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Positive Regulation Of Epithelial Cell Migration
Release From Viral Latency
Monocyte Differentiation
Axon Regeneration
Response To Endoplasmic Reticulum Stress
Leading Edge Cell Differentiation
Response To Muscle Stretch
Regulation Of Cell Population Proliferation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Negative Regulation Of Neuron Apoptotic Process
Host-mediated Suppression Of Viral Transcription
Host-mediated Activation Of Viral Transcription
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Response To Steroid Hormone
Regulation Of Cell Cycle
SMAD Protein Signal Transduction
Eyelid Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Calcium Ion
Cellular Response To Anisomycin
Integrated Stress Response Signaling
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of DNA-templated Transcription Initiation
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Pre-NOTCH Transcription and Translation
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Activation of anterior HOX genes in hindbrain development during early embryogenesis
MAPK6/MAPK4 signaling
TP53 Regulates Transcription of DNA Repair Genes
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Regulation of PD-L1(CD274) transcription
Vitamin D (calciferol) metabolism
SUMO is conjugated to E1 (UBA2:SAE1)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is proteolytically processed
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Adapalene
Vinblastine
Pseudoephedrine
Irbesartan
Arsenic trioxide
LGD-1550
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Cognitive performance (
19734545
)
Night sleep phenotypes (
27126917
)
Deep white matter hyperintensities (
32517579
)
Gamma glutamyl transferase levels (
29403010
33339817
)
Serum metabolite levels (
33031748
)
Type 2 diabetes (
32499647
)
Interacting Genes
181 interacting genes:
ABL1
AKAP5
APLP2
APP
AR
ARRB1
ATF1
ATF2
ATF3
ATF4
BATF
BATF2
BBS7
BCL3
BCL6
BLM
BRCA1
CASP9
CCND1
CEBPE
CEBPG
CLINT1
COP1
COPS5
CREB3
CREB5
CREBBP
CSNK2A1
DACH1
DDIT3
DDX21
DHX9
DNMT3L
EDF1
EGR1
ELF3
ELOF1
EN1
EP300
EPAS1
ERG
ESR1
ETS1
ETS2
ETV1
ETV4
EWSR1
FBXW7
FOS
FOSL1
FOSL2
GATA2
GGA1
GGA2
GOPC
GSK3B
GTF2B
GTF2E2
GTF2F1
GTF2F2
HCFC1
HDAC3
HDAC9
HDGF
HHEX
HIF1A
HMGA1
HNRNPM
HOXA9
HOXC8
HSP90AA1
HSPA8
IKBKB
IRAK1
ITCH
ITPK1
JDP2
KLF5
KMT2C
KPNA2
M6PR
MACF1
MAF
MAFB
MAP2K4
MAP2K7
MAPK10
MAPK11
MAPK14
MAPK3
MAPK8
MAPK9
MAPKAPK5
MAPRE3
MBD3
MDM2
MECOM
MOK
MTA1
MYBBP1A
MYOD1
NACA
NAT14
NCOA1
NCOA2
NCOA3
NCOA6
NCOR2
NEDD4
NELFB
NFE2L1
NFE2L2
NFYA
NR3C1
NR5A1
NRIP1
NTRK3
PACS1
PHOX2A
PIAS1
PIAS2
PIN1
POU1F1
PPARG
PPP3CB
PPP4C
PRKD1
PRKDC
PRRC2A
RB1
RBM39
RELA
RNF187
RPL18A
RPS6KA2
RUNX1
RUNX2
SKI
SMAD2
SMAD3
SMAD4
SMARCD1
SMARCD3
SNAPC5
SNRK
SOX10
SOX8
SP1
SPI1
SPIB
STAT1
STAT3
STAT4
STRN4
SUMO1
SUMO2
SUMO3
SUMO4
TAF1
TAF4
TBP
TCF20
TCF4
TDG
TGIF1
TOP1
TOP2A
TP53
TPM1
TPM2
TRAF2
TRIP4
TSC22D3
TSG101
UBB
UBC
UBE2I
USP6
VAV1
VDR
ZBTB7C
459 interacting genes:
AARS1
ABCF1
ABRAXAS1
ACIN1
ACTB
AFG2A
AFG2B
AHCYL1
AHNAK
AHNAK2
AIMP1
ALAS1
ANAPC1
ANAPC2
ANLN
ANXA1
APRT
ARF3
ARF4
ARID2
ARK2N
ARRB2
ASNS
ASS1
ATF7IP
ATRX
ATXN7
BABAM2
BAD
BAZ1A
BAZ1B
BLM
BOD1L1
BPTF
BRCC3
BZW1
CAD
CALM1
CARS1
CAST
CCAR2
CCNE2
CCT2
CCT3
CCT4
CCT5
CCT6A
CDK2
CEBPA
CENPC
CHAF1A
CHAF1B
CHAMP1
CHD3
CHD4
CHD8
CKAP5
CLTC
CMTM6
COPA
COPB2
COPG1
CPSF2
CPSF7
CSE1L
CSNK2B
CTNNBL1
CTNND1
CTR9
CUL3
CUX1
DAB2
DARS1
DAXX
DCD
DDX1
DDX17
DDX21
DDX39A
DDX3X
DDX5
DIDO1
DIP2B
DNAJA1
DNM1L
DNMT1
DYNC1H1
EDC4
EEF1A1
EEF1A2
EEF1G
EEF2
EFTUD2
EGLN3
EHD4
EHMT1
EIF4A1
EIF4A2
EIF4G1
EIF4G2
EIF5A
ELAC2
EME1
EMG1
EML3
ENO1
EP300
EP400
EPPK1
EPRS1
ERCC4
ERCC6
EXOSC10
EXOSC9
EZR
FARSB
FASN
FBXO38
FLNA
FLNB
FOS
GALK1
GAPVD1
GATAD2B
GCN1
GEMIN5
GPATCH8
GTF2I
GTF3C1
GTF3C2
GTF3C4
GYS1
HCFC1
HDAC1
HDAC2
HDAC4
HDAC9
HDLBP
HIPK2
HK2
HMGXB4
HNRNPA0
HNRNPA1L2
HNRNPA2B1
HNRNPF
HNRNPH1
HNRNPH2
HNRNPK
HNRNPL
HNRNPLL
HNRNPM
HNRNPR
HNRNPU
HOMEZ
HP1BP3
HPS6
HSF2
HSP90AA1
HSP90AB1
HSPA1A
HSPA5
HSPA8
HSPA9
HSPB1
HSPD1
HUWE1
IARS1
ILK
IMPDH2
INTS3
IPO5
IQGAP1
JUN
KALRN
KARS1
KDM1A
KDM5C
KIF11
KIF18B
KIF23
KIF2A
KIF2C
KIF4A
KIF5B
KPNA2
KRT8
LARS1
LAS1L
LEF1
LMNA
LMO7
MAF1
MAP4
MARS1
MAST2
MCM3
MCM4
MDC1
MDN1
MKI67
MMS19
MORC3
MPI
MRE11
MSH2
MSH3
MSH6
MSX1
MTA1
MTA2
MTHFD1
MUS81
MYB
MYG1
NAP1L1
NARS1
NAT10
NBN
NCAPD2
NCAPD3
NCAPG
NCAPH2
NCL
NCOR1
NFATC2IP
NFE2L2
NIBAN2
NIPBL
NOL9
NONO
NOP2
NPM1
NSUN2
NUMA1
NUP107
NUP160
NUP214
ORC3
P4HA1
P4HB
PAF1
PALLD
PARN
PARP1
PBRM1
PCBP2
PDCD4
PDCD6IP
PDS5A
PELP1
PFKL
PFKM
PFKP
PGK1
PHF3
PHF5A
PHF8
PIAS1
PIAS2
PIAS3
PIAS4
PKM
PKN2
PLEC
PML
POGZ
POLA1
POLD1
POLR2A
PPIE
PPP1CC
PPP2R1A
PRC1
PRDX6
PRKDC
PRPF6
PRPF8
PSMC1
PSMC3
PSMC4
PSMC5
PTBP1
RAD21
RAD50
RAD51
RAD54L2
RAN
RANBP2
RANGAP1
RARS1
RBBP4
RBBP7
RCC1
RCOR1
RCOR2
RCOR3
RFC2
RFC4
RFC5
RIF1
RNF111
RNF168
RNF20
RNF213
RNF216
RNF4
RNF8
RPL10
RPL3
RPL4
RPS3
RPS4X
RPS6KA3
RREB1
RRM1
RUVBL1
S100A10
SAE1
SAFB
SAFB2
SALL1
SAMHD1
SARS1
SART1
SCAF11
SENP1
SENP2
SENP3
SENP5
SENP6
SENP7
SERPINB6
SETDB1
SETX
SF3A1
SF3B1
SF3B2
SIMC1
SIN3A
SIRT1
SLC22A2
SLX4IP
SMARCA4
SMARCAD1
SMC1A
SMC3
SMC4
SMCHD1
SND1
SNRNP200
SNW1
SNX27
SOBP
SOX10
SOX6
SP1
SP100
SPR
SPTAN1
SPTBN1
SRCAP
SRP68
SRRM2
SRRT
SSRP1
STAG2
STIP1
STRAP
SUPT16H
SUPT5H
SYMPK
SYNCRIP
TAF1
TAGLN2
TCERG1
TCP1
TDG
TDP2
TEAD3
TEX10
TK1
TLN1
TMPO
TNIP1
TOP2A
TOP2B
TOPORS
TP53BP1
TP53BP2
TPR
TPX2
TRAF1
TRIM25
TRIM26
TRIM28
TRIM63
TRIML2
TRIP13
TRMT1L
TSR1
TTI1
TTLL12
TUBA1B
TUBA1C
TUBA4A
TUBB
TUBB4A
TUBB4B
TUBB6
U2AF2
UBA1
UBA2
UBAP2L
UBE2I
UBR4
UIMC1
UMPS
UPF1
USP11
USP25
USP28
USP36
USP48
USP5
USP7
USP9X
USPL1
VARS1
VIM
WAPL
WASHC2C
WDHD1
WRN
XAB2
XPNPEP1
XPO1
XPO5
XRCC5
XRCC6
YWHAQ
ZBED1
ZBTB2
ZBTB25
ZBTB33
ZBTB39
ZC3H11A
ZCCHC12
ZCCHC7
ZHX1
ZMAT3
ZMIZ2
ZMYM2
ZMYM3
ZMYM4
ZMYM5
ZMYND8
ZNF451
ZNF496
ZNF638
Entrez ID
3725
6613
HPRD ID
01302
04332
Ensembl ID
ENSG00000177606
ENSG00000188612
Uniprot IDs
P05412
P61956
PDB IDs
1A02
1FOS
1JNM
1JUN
1S9K
1T2K
5FV8
5T01
6Y3V
8SOS
1WM2
1WM3
1WZ0
2AWT
2CKH
2D07
2IO0
2IO3
2IYD
2N1W
2N9E
2RPQ
3UIN
3UIO
3ZO5
4BKG
4NPN
5D2M
5ELU
5EQL
5GHB
5GHC
6JXW
6JXX
7ZJV
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Chromatin
Regulation Of Primary Metabolic Process
Regulation Of Macromolecule Metabolic Process
Nucleus
Nucleoplasm
Regulation Of Metabolic Process
DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Transcription Regulator Complex
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-templated Transcription
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Regulator Complex
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Negative Regulation Of Biosynthetic Process
Sequence-specific DNA Binding
Transcription By RNA Polymerase II
Intracellular Signal Transduction
Negative Regulation Of Metabolic Process
Regulation Of Cell Differentiation
Cellular Developmental Process
Intracellular Signaling Cassette
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Nucleobase-containing Compound Biosynthetic Process
Nucleus
Nucleoplasm
Nucleic Acid Metabolic Process
RNA Binding
Nucleobase-containing Compound Metabolic Process
Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Metabolic Process
DNA Metabolic Process
DNA Repair
ATP Hydrolysis Activity
Regulation Of Metabolic Process
DNA Damage Response
ATP Binding
Nucleotide Binding
Cellular Response To Stress
Cytosol
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
RNA Metabolic Process
Regulation Of DNA Metabolic Process
Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Chromatin Organization
Chromosome
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Nucleolus
Cytoplasm
Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Chromatin Remodeling
Chromatin Binding
Positive Regulation Of Metabolic Process
Regulation Of Chromosome Organization
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Negative Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Chromosome Organization
Positive Regulation Of Macromolecule Biosynthetic Process
Chromosome, Telomeric Region
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of DNA Metabolic Process
Double-strand Break Repair
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