JUN and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 16620772)
0

Data Source:
HPRD (in vivo)

		JUN	SUMO3
Description		Jun proto-oncogene, AP-1 transcription factor subunit	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Nuclear Chromosome Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Transcription Factor AP-1 Complex RNA Polymerase II Transcription Regulator Complex	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding GTPase Activator Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding General Transcription Initiation Factor Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein Tag Activity Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Microglial Cell Activation Liver Development Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway JNK Cascade Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Epithelial Cell Migration Release From Viral Latency Monocyte Differentiation Axon Regeneration Response To Endoplasmic Reticulum Stress Leading Edge Cell Differentiation Response To Muscle Stretch Regulation Of Cell Population Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Response To Steroid Hormone Regulation Of Cell Cycle SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Calcium Ion Cellular Response To Anisomycin Integrated Stress Response Signaling Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of DNA-templated Transcription Initiation	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping Signaling by ALK fusions and activated point mutants Regulation of PD-L1(CD274) transcription	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs		Adapalene Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)	Delirium ( 29631748)
Interacting Genes		181 interacting genes: ABL1 AKAP5 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GGA1 GGA2 GOPC GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MECOM MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TP53 TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C	62 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A COPS5 CUL3 DAXX EGLN3 FAM221A FOS HIPK1 HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 MORC3 PAX6 PCGF2 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RAD54L2 RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SNRNP70 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZMYM2 ZNF451 ZNF496
Entrez ID		3725	6612
HPRD ID		01302	03754
Ensembl ID		ENSG00000177606	ENSG00000184900
Uniprot IDs		P05412	P55854
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01 6Y3V 8SOS	1U4A 2IO1 2MP2 6K5R 6NNQ 7R2E 7ZJU
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Positive Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Chromatin Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Nucleoplasm Regulation Of Metabolic Process DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Negative Regulation Of Biosynthetic Process Sequence-specific DNA Binding Transcription By RNA Polymerase II Intracellular Signal Transduction Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Cellular Developmental Process Intracellular Signaling Cassette DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Nucleobase-containing Compound Biosynthetic Process	PML Body Protein Sumoylation Nucleus Nucleoplasm Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Post-translational Protein Modification Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Protein Modification Process Regulation Of Transcription By RNA Polymerase II SUMO Transferase Activity Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process SUMO Binding SMAD Protein Signal Transduction Cellular Response To Stress SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Postsynaptic Cytosol Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Post-translational Protein Modification Transcription Corepressor Activity Positive Regulation Of Macromolecule Metabolic Process DeSUMOylase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Protein Sumoylation Protein Desumoylation Transcription Coregulator Activity Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Presynaptic Cytosol
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