JUN and PIN1

Number of citations of the paper that reports this interaction (PMID 11432833)
89

Data Source:
HPRD (in vitro, in vivo)

		JUN	PIN1
Gene Name		jun proto-oncogene	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytosol Transcriptional Repressor Complex	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Midbody
	Molecular Function	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Rho GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding R-SMAD Binding HMG Box Domain Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Phosphoserine Binding Phosphothreonine Binding
	Biological Process	Angiogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Liver Development Positive Regulation Of Endothelial Cell Proliferation Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Import Into Nucleus Aging Learning Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Response To Mechanical Stimulus Monocyte Differentiation Axon Regeneration Negative Regulation Of Protein Autophosphorylation Positive Regulation Of Rho GTPase Activity Response To Lipopolysaccharide Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Leading Edge Cell Differentiation TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Response To Drug Response To Hydrogen Peroxide Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Innate Immune Response Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Potassium Ion Starvation Stress-activated MAPK Cascade Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Cellular Response To Calcium Ion Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Protein Peptidyl-prolyl Isomerization Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Motility
Pathways		Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Activation of the AP-1 family of transcription factors MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Pre-NOTCH Transcription and Translation MyD88 dependent cascade initiated on endosome Pre-NOTCH Expression and Processing TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signaling by NOTCH TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade Senescence-Associated Secretory Phenotype (SASP) MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Oxidative Stress Induced Senescence Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Fc epsilon receptor (FCERI) signaling MAPK targets/ Nuclear events mediated by MAP kinases	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs		Vinblastine Irbesartan Arsenic trioxide
Diseases
GWAS		Cognitive performance ( 19734545)
Protein-Protein Interactions		185 interactors: ABL1 APLP2 APP AR ARRB1 ASCC1 ASCC2 ASCC3 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BATF3 BBS7 BCL3 BCL6 BRCA1 CASP9 CEBPE CEBPG CLINT1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 CREB3 CREB5 CREBBP CSNK2A1 CSNK2A2 CSNK2B DACH1 DDIT3 DDX21 DHX9 EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSL1 FOSL2 GATA2 GOPC GPS1 GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAP3K1 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFATC2 NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RFWD2 RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBE2I VAV1 VDR	184 interactors: ABI2 ADAMTSL4 ADARB1 AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ATP5B BAG6 BCL2 BCL6 BCLAF1 CAPRIN1 CARHSP1 CASP6 CBS CCDC184 CCDC33 CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 EFTUD2 EIF3G EP300 ETV6 FASLG FOXO4 FOXP2 G3BP1 G3BP2 GGA2 GOLGA2 GPAA1 GPHN HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ IKZF1 IKZF3 JAKMIP2 JUN KIAA1429 KIF20B KIF5A KLHL20 KMT2B KRT31 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX2 MOCS1 MTFR1 MTUS2 MYT1 NAB2 NCOA3 NEK6 NFATC2 NONO NUP62 PABPC1 PKIB PKM PKMYT1 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS RAB4A RAF1 RAI1 RARA RBBP8 RBPMS RELA REPS1 RNPS1 RPL4 RPS6KB1 SFPQ SHKBP1 SMAD3 SNRNP200 SOCS3 SPERT SREK1 SRRM1 SRRM2 SRSF11 SSBP3 STIL SUPT5H TAB3 TBC1D4 TCF4 TFG THAP7 THRAP3 TLE3 TNIP1 TOP2A TP53 TP73 TRAF1 TRAF2 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN4 UNC119 WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB22 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446
Entrez ID		3725	5300
HPRD ID		01302	03031
Ensembl ID		ENSG00000177606	ENSG00000127445
Uniprot IDs		P05412	Q13526
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K	1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M9E 2M9F 2M9I 2M9J 2Q5A 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Cellular Response To Stress Cell Differentiation Multicellular Organismal Development Response To Organic Substance Anatomical Structure Development Response To Stress Organ Development Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance System Development DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter	RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle RNA Processing Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Death Death Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated MRNA Processing Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation
Tagcloud ?		acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield	13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes
Tagcloud (Difference) ?		acidic administered adulthood artificial biased ca3 cerebrospinal counting delayed excitotoxins fibrillary glial immediate intracerebroventricular ka kainic limbic neuronal neuropsychiatric neurotoxicity nmol p14 p45 p7 p75 perhaps preweanling produce subfield	13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes
Tagcloud (Intersection) ?