LTA4H and TINF2

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		LTA4H	TINF2
Gene Name		leukotriene A4 hydrolase	TERF1 (TRF1)-interacting nuclear factor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Perinucleolar Chromocenter Nuclear Matrix
	Molecular Function	Aminopeptidase Activity Epoxide Hydrolase Activity Leukotriene-A4 Hydrolase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Poly(A) RNA Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Proteolysis Leukotriene Metabolic Process Inflammatory Response Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Peptide Catabolic Process Small Molecule Metabolic Process	Telomere Maintenance Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein ADP-ribosylation Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Leukotrienes (LT) and Eoxins (EX)	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine 3-(Benzyloxy)Pyridin-2-Amine Bestatin 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole N-(pyridin-3-ylmethyl)aniline (4-fluorophenyl)(pyridin-4-yl)methanone 1-(2,2\'-bithiophen-5-yl)methanamine N-[4-(benzyloxy)phenyl]glycinamide (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid 4-amino-N-[4-(benzyloxy)phenyl]butanamide N-methyl-1-(2-thiophen-2-ylphenyl)methanamine {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 1-(4-thiophen-2-ylphenyl)methanamine N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 4-(2-amino-1,3-thiazol-4-yl)phenol N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanine 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol
Diseases
GWAS		Height ( 20966902)
Protein-Protein Interactions		3 interactors: ARPC3 TINF2 TMEM62	88 interactors: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CTTN DBN1 DCX DHFRL1 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM POT1 PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		4048	26277
HPRD ID		01056	16056
Ensembl ID		ENSG00000111144	ENSG00000092330
Uniprot IDs		P09960	B4DFJ1 Q9BSI4
PDB IDs		1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR	3BQO 3BU8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein ADP-ribosylation Regulation Of Protein ADP-ribosylation Positive Regulation Of Organelle Organization Negative Regulation Of Protein Glycosylation Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Telomere Assembly Negative Regulation Of Telomere Maintenance Regulation Of Protein Glycosylation Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Telomere Maintenance Regulation Of Organelle Organization Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of DNA Replication Actin Nucleation Telomere Maintenance Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Ephrin Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization	Negative Regulation Of Telomere Maintenance Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Glycolytic Process Protection From Non-homologous End Joining At Telomere Carbohydrate Catabolic Process Negative Regulation Of DNA Replication Telomere Assembly Catabolic Process Negative Regulation Of DNA Metabolic Process Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Catalytic Activity Positive Regulation Of Telomerase Activity Pyruvate Metabolic Process Telomere Maintenance Telomere Maintenance Via Telomerase Pathogenesis Generation Of Precursor Metabolites And Energy Glucose Metabolic Process Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Chromosome Organization Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of DNA Biosynthetic Process Regulation Of Catalytic Activity Carboxylic Acid Metabolic Process Age-dependent Telomere Shortening Telomeric Loop Formation Nervous System Development Regulation Of Signaling Positive Regulation Of DNA Biosynthetic Process Glycogen Metabolic Process RNA-dependent DNA Replication Nucleoside Metabolic Process Telomere Maintenance Via Telomere Shortening Regulation Of Signal Transduction Hexose Metabolic Process Cellular Process Regulation Of DNA Replication Monocarboxylic Acid Metabolic Process Cellular Carbohydrate Metabolic Process Response To Stimulus Protein Localization To Chromosome Organelle Organization Telomere Maintenance Via Telomere Lengthening Polysaccharide Metabolic Process
Tagcloud ?		69kda abilities alb amylase capability de depletion desmoplakin elute eluted fluids iggs immunoaffinity immunoglobulins page plastin remove removing saa salivary sequentially spots tag triple twofold unmasked venue visualization visualized	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Difference) ?		69kda abilities alb amylase capability de depletion desmoplakin elute eluted fluids iggs immunoaffinity immunoglobulins page plastin remove removing saa salivary sequentially spots tag triple twofold unmasked venue visualization visualized	acd add broader clustered clustering convincingly correction cosegregated ends families fisher germline inactivating lod logarithm melanoma nonsense pot1 predispose probands q320x r364x shelterin tailed terf1 terf2 terf2ip yates
Tagcloud (Intersection) ?