LTA4H and ARPC3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		LTA4H	ARPC3
Description		leukotriene A4 hydrolase	actin related protein 2/3 complex subunit 3
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Cytoskeleton Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Cell Leading Edge Filamentous Actin Site Of Double-strand Break Cell Projection Growth Cone Leading Edge Extracellular Exosome
	Molecular Function	RNA Binding Aminopeptidase Activity Epoxide Hydrolase Activity Leukotriene-A4 Hydrolase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Tripeptide Aminopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Proteolysis Lipid Metabolic Process Leukotriene Metabolic Process Response To Zinc Ion Leukotriene Biosynthetic Process Protein Metabolic Process Peptide Catabolic Process Response To Peptide Hormone Type I Pneumocyte Differentiation	Regulation Of Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Actin Polymerization-dependent Cell Motility Regulation Of Synaptic Vesicle Endocytosis Cellular Response To Nerve Growth Factor Stimulus
Pathways		Synthesis of Leukotrienes (LT) and Eoxins (EX) Neutrophil degranulation Biosynthesis of D-series resolvins Biosynthesis of protectins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Captopril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine 3-(Benzyloxy)Pyridin-2-Amine Imidazole Ubenimex DG051 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole N-(pyridin-3-ylmethyl)aniline (4-fluorophenyl)(pyridin-4-yl)methanone 1-(2,2'-bithiophen-5-yl)methanamine N-[4-(benzyloxy)phenyl]glycinamide (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid 4-amino-N-[4-(benzyloxy)phenyl]butanamide N-methyl-1-(2-thiophen-2-ylphenyl)methanamine {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 1-(4-thiophen-2-ylphenyl)methanamine N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 4-(2-amino-1,3-thiazol-4-yl)phenol Kelatorphan 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol Tosedostat	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Blood protein levels ( 30072576) Diffusing capacity of carbon monoxide ( 30694715) Height ( 20966902) Refractive error ( 32231278) Small intestine neuroendocrine tumor ( 27492634) Thyroid stimulating hormone levels ( 32769997)	Automobile speeding propensity ( 30643258) Bipolar disorder ( 31043756) Femoral neck bone mineral density ( 30172743)
Interacting Genes		3 interacting genes: ARPC3 TINF2 TMEM62	31 interacting genes: ACTR3 ARAP1 ARPC4 BAG6 CCR10 CDKN2B CEBPA CETP DUSP29 EFTUD2 FAM9A GOLGA2 HOXA3 LATS1 LGALS4 LTA4H MAPK6 NRIP1 OTUD5 POU2F1 PRMT1 RBBP8NL RETREG3 RPS4X SYBU TARS3 THNSL2 WAS WASF2 WASL ZNF576
Entrez ID		4048	10094
HPRD ID		01056	09175
Ensembl ID		ENSG00000111144	ENSG00000111229
Uniprot IDs		A0A140VK27 P09960	O15145
PDB IDs		1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR 4L2L 4MKT 4MS6 4R7L 4RSY 4RVB 5AEN 5BPP 5FWQ 5N3W 5NI2 5NI4 5NI6 5NIA 5NID 5NIE 6ENB 6ENC 6END 6O5H 7AUZ 7AV0 7AV1 7AV2 7KZE 7LLQ 8AVA 8AWH 8QOW 8QPN 8QQ4 8RX3 8RX7 8RX9 8TWX	6UHC 6YW6 6YW7 8P94
Enriched GO Terms of Interacting Partners?		Growth Cone Leading Edge Perinucleolar Chromocenter Arp2/3 Protein Complex Actin Polymerization-dependent Cell Motility Nuclear Telomere Cap Complex Shelterin Complex Telomere Assembly Protein Localization To Chromosome, Telomeric Region Telomere Capping Actin Nucleation Filamentous Actin Regulation Of Synaptic Vesicle Endocytosis Arp2/3 Complex-mediated Actin Nucleation Regulation Of Synaptic Vesicle Recycling Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of Telomere Maintenance Via Telomerase	Regulation Of Cell Projection Assembly Negative Regulation Of Actin Filament Bundle Assembly Actin Filament Polymerization Regulation Of Lamellipodium Assembly Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Regulation Of Actin Filament Organization Actin Filament Organization Regulation Of Lamellipodium Organization Arp2/3 Protein Complex Actin Polymerization Or Depolymerization Actin Cytoskeleton Actin Filament-based Movement HMG Box Domain Binding Asymmetric Cell Division Protein Polymerization Regulation Of Actin Cytoskeleton Organization Nucleus Arp2/3 Complex-mediated Actin Nucleation Positive Regulation Of Cell Projection Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Stress Fiber Assembly Regulation Of Supramolecular Fiber Organization Site Of Double-strand Break
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