LTA4H

Gene Name		leukotriene A4 hydrolase
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Aminopeptidase Activity Epoxide Hydrolase Activity Leukotriene-A4 Hydrolase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Proteolysis Leukotriene Metabolic Process Inflammatory Response Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Peptide Catabolic Process Small Molecule Metabolic Process
Pathways		Arachidonic acid metabolism Metabolism of lipids and lipoproteins Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs		N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine 3-(Benzyloxy)Pyridin-2-Amine Bestatin 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole N-(pyridin-3-ylmethyl)aniline (4-fluorophenyl)(pyridin-4-yl)methanone 1-(2,2\'-bithiophen-5-yl)methanamine N-[4-(benzyloxy)phenyl]glycinamide (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid 4-amino-N-[4-(benzyloxy)phenyl]butanamide N-methyl-1-(2-thiophen-2-ylphenyl)methanamine {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 1-(4-thiophen-2-ylphenyl)methanamine N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 4-(2-amino-1,3-thiazol-4-yl)phenol N-[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]-L-alanine 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol
Diseases
GWAS		Height ( 20966902)
Protein-protein Interactions		3 interactors: ARPC3 TINF2 TMEM62
Entrez ID		4048
HPRD ID		01056
Ensembl ID		ENSG00000111144
Uniprot IDs		P09960
PDB IDs		1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein ADP-ribosylation Regulation Of Protein ADP-ribosylation Positive Regulation Of Organelle Organization Negative Regulation Of Protein Glycosylation Negative Regulation Of Telomere Maintenance Via Telomerase Protein Localization To Chromosome, Telomeric Region Telomere Assembly Negative Regulation Of Telomere Maintenance Regulation Of Protein Glycosylation Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Telomere Maintenance Regulation Of Organelle Organization Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of DNA Replication Actin Nucleation Telomere Maintenance Regulation Of Cellular Component Organization Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Ephrin Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization
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