LTA4H

Description		leukotriene A4 hydrolase
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Aminopeptidase Activity Epoxide Hydrolase Activity Leukotriene-A4 Hydrolase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Tripeptide Aminopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Proteolysis Lipid Metabolic Process Leukotriene Metabolic Process Response To Zinc Ion Leukotriene Biosynthetic Process Protein Metabolic Process Peptide Catabolic Process Response To Peptide Hormone Type I Pneumocyte Differentiation
Pathways		Synthesis of Leukotrienes (LT) and Eoxins (EX) Neutrophil degranulation Biosynthesis of D-series resolvins Biosynthesis of protectins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins
Drugs		Captopril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine 3-(Benzyloxy)Pyridin-2-Amine Imidazole Ubenimex DG051 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole N-(pyridin-3-ylmethyl)aniline (4-fluorophenyl)(pyridin-4-yl)methanone 1-(2,2'-bithiophen-5-yl)methanamine N-[4-(benzyloxy)phenyl]glycinamide (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid 4-amino-N-[4-(benzyloxy)phenyl]butanamide N-methyl-1-(2-thiophen-2-ylphenyl)methanamine {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 1-(4-thiophen-2-ylphenyl)methanamine N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 4-(2-amino-1,3-thiazol-4-yl)phenol Kelatorphan 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol Tosedostat
Diseases
GWAS		Blood protein levels ( 30072576) Diffusing capacity of carbon monoxide ( 30694715) Height ( 20966902) Refractive error ( 32231278) Small intestine neuroendocrine tumor ( 27492634) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		3 interacting genes: ARPC3 TINF2 TMEM62
Entrez ID		4048
HPRD ID		01056
Ensembl ID		ENSG00000111144
Uniprot IDs		A0A140VK27 P09960
PDB IDs		1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR 4L2L 4MKT 4MS6 4R7L 4RSY 4RVB 5AEN 5BPP 5FWQ 5N3W 5NI2 5NI4 5NI6 5NIA 5NID 5NIE 6ENB 6ENC 6END 6O5H 7AUZ 7AV0 7AV1 7AV2 7KZE 7LLQ 8AVA 8AWH 8QOW 8QPN 8QQ4 8RX3 8RX7 8RX9 8TWX
Enriched GO Terms of Interacting Partners?		Growth Cone Leading Edge Perinucleolar Chromocenter Arp2/3 Protein Complex Actin Polymerization-dependent Cell Motility Nuclear Telomere Cap Complex Shelterin Complex Telomere Assembly Protein Localization To Chromosome, Telomeric Region Telomere Capping Actin Nucleation Filamentous Actin Regulation Of Synaptic Vesicle Endocytosis Arp2/3 Complex-mediated Actin Nucleation Regulation Of Synaptic Vesicle Recycling Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of Telomere Maintenance Via Telomerase
Tagcloud ?