CD82 and CD19

Number of citations of the paper that reports this interaction (PubMedID 9804823)
0

Data Source:
HPRD (in vivo)

		CD82	CD19
Description		CD82 molecule	CD19 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Membrane Protein-containing Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding
	Biological Process		B-1 B Cell Differentiation Adaptive Immune Response B Cell Proliferation Involved In Immune Response Immune System Process Immunoglobulin Mediated Immune Response B Cell Mediated Immunity B Cell Proliferation Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of B Cell Receptor Signaling Pathway Regulation Of B Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways			PIP3 activates AKT signaling Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Regulation of Complement cascade Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Coltuximab ravtansine Blinatumomab Depatuxizumab mafodotin Inebilizumab Tisagenlecleucel Axicabtagene ciloleucel Tafasitamab Brexucabtagene autoleucel Loncastuximab tesirine Lisocabtagene maraleucel
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Blond vs. brown/black hair color ( 30531825) Cadmium levels ( 26025379) Hemostatic factors and hematological phenotypes ( 22443383) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte count ( 32888494) Male-pattern baldness ( 27182965) Mean reticulocyte volume ( 32888494) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) TNF-alpha gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		29 interacting genes: BDKRB2 BRCC3 CANX CD19 CD4 CD63 CHRM5 CREB3 EGFR ERBB2 ERBB3 FFAR2 HBEGF HLA-DMA HLA-DMB HLA-DRA IGSF8 ITGA3 ITGA4 ITGA6 ITGB1 ITGB2 KLRC1 LRP1 NLRP3 NUP88 PTGFRN SMIM3 VANGL1	21 interacting genes: ABL1 BTK CBL CD22 CD79A CD79B CD81 CD82 CD9 CR2 ECT2 FYN GRB2 LYN MAPK1 PIK3R1 PLCG2 SOS1 SYK VAV1 VAV2
Entrez ID		3732	930
HPRD ID		09004	00113
Ensembl ID		ENSG00000085117	ENSG00000177455
Uniprot IDs		P27701	P15391
PDB IDs			6AL5 7JIC 7URV 7URX
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Complex Integrin Complex Cell Surface Receptor Signaling Pathway Membrane Positive Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Process Signaling Receptor Activity Cell-matrix Adhesion Regulation Of Cell Adhesion ERBB2 Signaling Pathway Immune System Process MHC Class II Protein Complex Binding Regulation Of Leukocyte Cell-cell Adhesion Cell-substrate Adhesion ERBB2-EGFR Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Plasma Membrane Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Cell Migration ERBB3:ERBB2 Complex MHC Class II Protein Complex Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Coreceptor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Immune System Process Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Immune Effector Process Focal Adhesion Clathrin-coated Endocytic Vesicle Membrane Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Integrin Alpha4-beta1 Complex ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery	Immune Response-activating Cell Surface Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Lymphocyte Activation Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response B Cell Activation Phosphotyrosine Residue Binding Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Fc Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Effector Process Immune System Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Regulation Of Cell Activation Leukocyte Proliferation Positive Regulation Of Intracellular Signal Transduction Regulation Of Lymphocyte Activation B Cell Proliferation Plasma Membrane Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway B Cell Differentiation Lymphocyte Proliferation Mononuclear Cell Differentiation Mononuclear Cell Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Ephrin Receptor Binding Immune Response Leukocyte Differentiation Lymphocyte Differentiation Positive Regulation Of Signal Transduction Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of T Cell Activation Cellular Developmental Process Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Defense Response
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