CD82 and KLRC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CD82	KLRC1
Description		CD82 molecule	killer cell lectin like receptor C1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Cytoplasmic Vesicle Phagocytic Vesicle Extracellular Exosome	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Inhibitory MHC Class Ib Receptor Activity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process		Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Cadmium levels ( 26025379) Hemostatic factors and hematological phenotypes ( 22443383) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Lymphocyte count ( 32888494) Male-pattern baldness ( 27182965) Mean reticulocyte volume ( 32888494) Plasma parathyroid hormone levels ( 30134803) Red cell distribution width ( 27863252 28957414 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) TNF-alpha gene expression levels in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		29 interacting genes: BDKRB2 BRCC3 CANX CD19 CD4 CD63 CHRM5 CREB3 EGFR ERBB2 ERBB3 FFAR2 HBEGF HLA-DMA HLA-DMB HLA-DRA IGSF8 ITGA3 ITGA4 ITGA6 ITGB1 ITGB2 KLRC1 LRP1 NLRP3 NUP88 PTGFRN SMIM3 VANGL1	46 interacting genes: AKT1 ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CATSPERH CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC TMEM182 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1
Entrez ID		3732	3821
HPRD ID		09004	01192
Ensembl ID		ENSG00000085117	ENSG00000134545
Uniprot IDs		P27701	P26715
PDB IDs			2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Complex Integrin Complex Cell Surface Receptor Signaling Pathway Membrane Positive Regulation Of Cell Adhesion Regulation Of Multicellular Organismal Process Signaling Receptor Activity Cell-matrix Adhesion Regulation Of Cell Adhesion ERBB2 Signaling Pathway Immune System Process MHC Class II Protein Complex Binding Regulation Of Leukocyte Cell-cell Adhesion Cell-substrate Adhesion ERBB2-EGFR Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Signal Transduction Positive Regulation Of Immune Response Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Plasma Membrane Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Cell Migration ERBB3:ERBB2 Complex MHC Class II Protein Complex Integrin Alpha6-beta1 Complex Integrin Alpha3-beta1 Complex Coreceptor Activity Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Motility Regulation Of Immune System Process Cell Motility Positive Regulation Of Locomotion Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Immune Effector Process Focal Adhesion Clathrin-coated Endocytic Vesicle Membrane Regulation Of Locomotion Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation Integrin Alpha4-beta1 Complex ERBB Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Localization To Cell Periphery	Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Bleb Assembly Intercellular Transport Structural Constituent Of Myelin Sheath Natural Killer Cell Mediated Immunity Axon Ensheathment Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Gap Junction Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Innate Immune Response-activating Signaling Pathway Myelination Negative Regulation Of Neutrophil Activation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Gap Junction Assembly Positive Regulation Of Defense Response T Cell Costimulation Activation Of Innate Immune Response Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Lymphocyte Mediated Immunity Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Central Nervous System Myelination Endosomal Lumen Acidification Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Symbiont Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Proton-transporting V-type ATPase Complex Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane T Cell Activation Cell Communication By Electrical Coupling Regulation Of Tumor Necrosis Factor Production Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Carbohydrate Binding
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