LMO2 and CBY2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		LMO2	CBY2
Description		LIM domain only 2	chibby family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex	Cytoplasmic Vesicle
	Molecular Function	Transcription Coregulator Binding Transcription Coactivator Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding	Protein Binding Identical Protein Binding
	Biological Process	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Cognitive performance ( 19734545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Major depressive disorder x sex interaction ( 34099189) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Red blood cell count ( 27863252 32888494)
Interacting Genes		190 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 AIRIM ALDH6A1 ARHGEF5 ARID5A ARNT2 ATOSB AXIN1 BANP BCAS2 BEX2 BLZF1 BYSL C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DMRT3 DRAP1 DRC4 DSCAM DYDC1 EFHC1 EFHC2 EHMT2 EIF3B EIF4EBP1 ELF2 ENKD1 ERBIN FAAP20 FAM228A FAM90A1 FHL3 FHL5 GATA1 GATA2 GATA3 GFAP GMEB2 GOLGA2 GRB2 HDAC5 HNRNPC HNRNPM HOOK1 ICA1L IFT43 IHO1 IKZF1 IKZF3 INCA1 ISL1 ISY1 KANK2 KAZN KDM5A KIF2A KIF3B KLHL20 KPRP KRT15 KRT34 KRT40 KRT75 KRT80 KRTAP10-7 LDB1 LDB2 LDOC1 LMO4 LMOD3 LYL1 LZTS1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MISP MRFAP1L1 MSN MTUS2 MYOZ3 N4BP2L2 NCAPH2 NDOR1 NDUFAB1 NDUFB7 NFKBID NHLH1 NIF3L1 NOTCH2NLA NOXA1 NSMF NTAQ1 NUP62 NUTM1 PATZ1 PAX9 PBX4 PDE9A PHC2 POLR2G PRDM6 PRKG1 PSMA1 RBBP8 RCN1 REL RELA RINT1 RLIM ROCK1 RTL8C RUSC1 SAXO1 SAXO4 SGTB SKP1 SMAD2 SMUG1 SNAPC5 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TBX2 TCP10L TEKT3 TFIP11 TFPT THAP6 TLE5 TLX3 TRIB3 TRIM23 TRIM54 TRIM55 TRIM63 TRIP6 TSC1 TSC22D4 TSEN15 TSEN54 TSGA10IP TSPYL2 TSSK3 TUFT1 UBA6 UBASH3B UBE2I USH1G VBP1 VEZF1 VMAC WASF1 WASHC1 YOD1 YPEL3 ZFP64 ZMYND12 ZNF185 ZNF19 ZNF24 ZNF250 ZNF34 ZNF410 ZNF641 ZNF655 ZNF688	119 interacting genes: ACTN1 AIMP2 AIRIM ARHGEF40 ARMC7 BEX3 C19orf44 CCDC146 CCDC185 CCDC187 CCDC198 CCDC57 CCHCR1 CCNG1 CDC23 CDC37 CDK18 CDK2 CEP44 CEP55 CEP57L1 CEP95 CHCHD3 CHIC2 CIBAR1 CKS1B CNNM3 CYTH4 DGCR6 DTNB DUSP14 DZIP1L EFCAB3 EIF4E2 ELOA ENKD1 FAM161A FANCG FARS2 FBXO17 FRS3 GADD45A GADD45GIP1 GOLGA2 GOLGA6A GOLGA6L2 GRAP2 HAUS1 HSF2BP ING5 ISCU KIAA0408 KIFC3 KLC3 LATS1 LENG1 LMO1 LMO2 LMO3 LNX1 MCRS1 MED28 METTL17 MLH1 MMAB MOS NDUFA5 NEK6 NINL NME7 NTAQ1 OIP5 PID1 PIN1 PLEKHN1 POLR1C PPFIA3 PPP1R13B PPP1R18 PRPF18 PRPF31 RCOR3 RNF6 RPL9 RTP5 RUNX1T1 SCNM1 SDCBP SH3RF2 SNAPC5 SSX3 SYCE1 SYT17 TCEA2 TCEANC TCHP TEX11 TRIM42 TRIML2 TSC2 TSGA10 TSGA10IP TUBGCP4 TXK TXLNA TXLNB USHBP1 ZC2HC1C ZFYVE26 ZMAT2 ZNF250 ZNF417 ZNF564 ZNF572 ZNF581 ZNF655 ZNF688 ZNF764 ZNF785
Entrez ID		4005	220082
HPRD ID		01586	14856
Ensembl ID		ENSG00000135363	ENSG00000174015
Uniprot IDs		P25791	A0A140VJV5 Q8NA61
PDB IDs		2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Cytoskeleton Regulation Of RNA Metabolic Process Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Transcription Regulator Complex Nucleoplasm Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Mitotic Spindle Astral Microtubule End Cellular Developmental Process Microtubule DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Cell Differentiation Cytoplasm Microtubule Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Spindle Assembly Microtubule-based Process Neuron Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Erythrocyte Differentiation Microtubule Binding Developmental Process Transcription Cis-regulatory Region Binding Positive Regulation Of Erythrocyte Differentiation	Protein Binding Centrosome Cytoskeleton Centriole Spindle Pole Microtubule-based Process Microtubule Organizing Center Organization Organelle Organization Cell Division Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Ciliary Basal Body Male Meiosis Chromosome Segregation Microtubule Cytoskeleton Organization Centrosome Cycle Microtubule Binding
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