LMO2 and ELF2

Number of citations of the paper that reports this interaction (PMID 9001422)
2

Data Source:
HPRD (in vitro, two hybrid)

		LMO2	ELF2
Gene Name		LIM domain only 2 (rhombotin-like 1)	E74-like factor 2 (ets domain transcription factor)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Protein Binding Zinc Ion Binding BHLH Transcription Factor Binding Cofactor Binding E-box Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Multicellular Organismal Development Embryonic Hemopoiesis MRNA Transcription From RNA Polymerase II Promoter Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Thyroid Hormone Stimulus	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Cognitive performance ( 19734545)
Protein-Protein Interactions		96 interactors: ABI2 ADAMTSL4 AES AGTRAP AIMP2 ALDH6A1 AXIN1 BANP BEX2 BLZF1 C1orf94 CALCOCO2 CCDC33 CCDC36 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DRAP1 EHMT2 ELF2 ERBB2IP FAM154A FHL3 GATA1 GATA2 GATA3 GFAP GOLGA2 GRB2 HNRNPC HNRNPM HOOK1 IFT43 IKZF3 ISL1 KANK2 KDM5A KIF3B KRT15 KRT40 KRTAP10-7 LDB1 LYL1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MLLT4 MRFAP1L1 MTUS2 N4BP2L2 NCAPH2 NHLH1 NIF3L1 NOTCH2NL NUP62 NUTM1 PDE9A PHC2 PRKG1 RBBP8 REL RELA RINT1 RLIM ROCK1 SKP1 SMAD2 SOX5 SP1 SPERT SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TFPT TLX3 TRIM23 TRIM54 TRIP6 TSC22D4 TUFT1 UBE2I ZFP64 ZNF24	5 interactors: APP EIF2AK2 LMO2 RUNX1 ZBTB32
Entrez ID		4005	1998
HPRD ID		01586	16856
Ensembl ID		ENSG00000135363	ENSG00000109381
Uniprot IDs		P25791	B7Z720 E9PCX3 Q15723
PDB IDs		2XJY 2XJZ 2YPA
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Developmental Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Organelle Organization Biosynthetic Process Multicellular Organismal Development Positive Regulation Of Metabolic Process Anatomical Structure Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Negative Regulation Of Signal Transduction Cell Fate Commitment Definitive Hemopoiesis Regulation Of Cell Differentiation Negative Regulation Of Cell Differentiation Mitotic Cell Cycle Regulation Of Cell Proliferation Negative Regulation Of Signaling	Immune System Process Embryonic Hemopoiesis Negative Regulation Of Immune System Process RNA Metabolic Process Gene Expression Regulation Of Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Hemopoiesis Regulation Of Transcription, DNA-templated Evasion Or Tolerance By Virus Of Host Immune Response Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Immune System Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Progesterone Secretion Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Myeloid Cell Differentiation Collateral Sprouting In Absence Of Injury Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Progesterone Secretion Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Regulation Of Hair Follicle Cell Proliferation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Hematopoietic Stem Cell Proliferation Organ Development Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Translation Axon Choice Point Recognition Regulation Of Immune System Process Response To Host Immune Response Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Transcription, DNA-templated Regulation Of NLRP3 Inflammasome Complex Assembly Myeloid Progenitor Cell Differentiation
Tagcloud ?		chimeric chromosomal contribution die disruption embryonic encodes erythropoiesis finger hematopoiesis hematopoietic homozygous leukemias lim lineage lineages master null precluded prevents probably reintroduction rescues sac stages tal1 translocations vector yolk	agent bases clarke dai deduced delta dimers dsrbms dsrna extending footprinting mathews opposed p1 p68 pkr portion protected remarkable reproducibly ribonuclease rna segments stranded t1 tertiary thereof twice va
Tagcloud (Difference) ?		chimeric chromosomal contribution die disruption embryonic encodes erythropoiesis finger hematopoiesis hematopoietic homozygous leukemias lim lineage lineages master null precluded prevents probably reintroduction rescues sac stages tal1 translocations vector yolk	agent bases clarke dai deduced delta dimers dsrbms dsrna extending footprinting mathews opposed p1 p68 pkr portion protected remarkable reproducibly ribonuclease rna segments stranded t1 tertiary thereof twice va
Tagcloud (Intersection) ?