LIPC and LRP1

Number of citations of the paper that reports this interaction (PMID 7721852)
13

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		LIPC	LRP1
Gene Name		lipase, hepatic	low density lipoprotein receptor-related protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space High-density Lipoprotein Particle	Nucleolus Cytoplasm Lysosomal Membrane Endosome Plasma Membrane Integral Component Of Plasma Membrane Coated Pit Focal Adhesion Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Phospholipase Activity Triglyceride Lipase Activity Heparin Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding	Protease Binding Receptor Activity Calcium Ion Binding Protein Binding Protein Complex Binding Apolipoprotein Binding Lipoprotein Transporter Activity Poly(A) RNA Binding Lipoprotein Particle Receptor Binding
	Biological Process	Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis	Retinoid Metabolic Process Receptor-mediated Endocytosis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Aging Phototransduction, Visible Light Cholesterol Metabolic Process Cell Proliferation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Transport Beta-amyloid Clearance Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways			Scavenging of heme from plasma Visual phototransduction Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease (cognitive decline) ( 23535033) Amyotrophic lateral sclerosis ( 18084291) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Cognitive performance ( 20125193) HDL cholesterol ( 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) Hematological and biochemical traits ( 20139978) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 22916037 19043545) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 22359512) Red blood cell traits ( 23222517) Triglycerides ( 18193043 20686565)	Abdominal aortic aneurysm ( 22055160) HDL cholesterol ( 20686565) Migraine ( 22683712 21666692) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Triglycerides ( 20686565)
Protein-Protein Interactions		3 interactors: ADHFE1 APOB LRP1	63 interactors: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CD82 CTGF CTSG DAB1 DAB2 DLG4 ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 NOS1AP PDGFB PID1 PLAT PLAUR PRKACA RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		3990	4035
HPRD ID		01058	00138
Ensembl ID		ENSG00000166035	ENSG00000123384
Uniprot IDs		A6H8L5 E7EUJ1 P11150	Q07954 Q59FG2
PDB IDs			1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?		Lipoprotein Transport Artery Morphogenesis Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Beta-amyloid Clearance Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Molecular Hydrogen Transport Steroid Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Receptor-mediated Endocytosis Response To Selenium Ion Blood Vessel Morphogenesis Small Molecule Metabolic Process Very-low-density Lipoprotein Particle Assembly Response To Radiation Triglyceride Mobilization Blood Vessel Development Low-density Lipoprotein Particle Remodeling Regulation Of Phospholipase A2 Activity Vasculature Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Detection Of Stimulus 2-oxoglutarate Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Lipoprotein Catabolic Process Protein-lipid Complex Assembly Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Cholesterol Efflux Cellular Response To Prostaglandin Stimulus Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Regulation Of Cholesterol Efflux Low-density Lipoprotein Particle Clearance Aorta Morphogenesis Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling	Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Catalytic Activity Regulation Of Proteolysis Negative Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Response To Wounding Regulation Of Protein Phosphorylation Blood Coagulation Hemostasis Regulation Of Protein Kinase Activity Response To Stress Regulation Of Kinase Activity Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Endocytosis Negative Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Platelet Activation Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Protein Kinase Activity Regulation Of Body Fluid Levels Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction Wound Healing Regulation Of Protein Processing Vesicle-mediated Transport Positive Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Processing Locomotion Extracellular Matrix Disassembly Regulation Of Protein Binding Regulation Of Vesicle-mediated Transport Regulation Of Blood Coagulation Anatomical Structure Morphogenesis Response To Stimulus Secretion By Cell
Tagcloud ?		abcg2 accessed americans architecture blacks contrasting direction eagle ethnicities ethnicity exposing fourteen genotypic hispanic mexican nhanes phenome phewas pleiotropic pleiotropy protoporphyrin race replicated replicating rs1800588 rs2231142 snp surveys whites	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Difference) ?		abcg2 accessed americans architecture blacks contrasting direction eagle ethnicities ethnicity exposing fourteen genotypic hispanic mexican nhanes phenome phewas pleiotropic pleiotropy protoporphyrin race replicated replicating rs1800588 rs2231142 snp surveys whites	aacr an2 ang4043 angiopep bbb biologics bt confers conjugate conjugated conjugation crosses endows entity extending implanted indications intracarotid intracranially kin mab neuro penetrant penetrates penetration retains systemically ther transcytosis
Tagcloud (Intersection) ?