LIPC and APOB

Number of citations of the paper that reports this interaction (PubMedID 9685400)
0

Data Source:
HPRD (in vitro)

		LIPC	APOB
Description		lipase C, hepatic type	apolipoprotein B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen High-density Lipoprotein Particle	Extracellular Region Extracellular Space Cytoplasm Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Clathrin-coated Endocytic Vesicle Membrane Endosome Lumen Mature Chylomicron Chylomicron Remnant Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Chylomicron Neuronal Cell Body Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Endocytic Vesicle Lumen
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Triacylglycerol Lipase Activity Protein Binding Heparin Binding Phospholipase A1 Activity Lipase Activity Hydrolase Activity Low-density Lipoprotein Particle Binding Apolipoprotein Binding Carboxylic Ester Hydrolase Activity	Lipid Transporter Activity Protein Binding Phospholipid Binding Heparin Binding Lipase Binding Receptor Ligand Activity Low-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis	In Utero Embryonic Development Lipid Metabolic Process Triglyceride Mobilization Lipid Transport Signal Transduction Spermatogenesis Nervous System Development Steroid Metabolic Process Cholesterol Metabolic Process Fertilization Response To Virus Post-embryonic Development Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Lipid Catabolic Process Triglyceride Catabolic Process Cholesterol Transport Flagellated Sperm Motility Cholesterol Efflux Low-density Lipoprotein Particle Remodeling Very-low-density Lipoprotein Particle Assembly Low-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Lipoprotein Biosynthetic Process Lipoprotein Catabolic Process Cholesterol Homeostasis Lipoprotein Transport Regulation Of Cholesterol Biosynthetic Process Artery Morphogenesis Establishment Of Localization In Cell Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways		Assembly of active LPL and LIPC lipase complexes Chylomicron clearance	Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance Chylomicron clearance LDL clearance LDL clearance LDL remodeling VLDL clearance VLDL clearance Heme signaling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases			Hypercholesterolemia, autosomal dominant; Hyperlipoproteinemia, type IIa
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 21665990 23455636) Alanine aminotransferase levels ( 33547301 34315874) Alzheimer's disease (cognitive decline) ( 23535033) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Amyotrophic lateral sclerosis ( 18084291) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301 34315874) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol efflux capacity ( 30369316) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Cognitive performance ( 20125193) Eosinophil count ( 32888494) Gout ( 22179738) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 18193043 18193044 19060906 19060910 19060911 20686565 20864672 21347282 23505323 24097068 25961943 26160806 26582766 26780889 29404214) HDL cholesterol levels ( 26690388 28334899 30698716 31087446 31694877 32203549 32759990) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels in HIV infection ( 33109212) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29403010 29615537 30718733 31211820 33339817 33499410) Ischemic stroke ( 26089329) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222 22286219) Lipid traits ( 24023260 24386095) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Lymphocyte count ( 32888494) Lysophosphatidylethanolamine levels ( 31551469) Metabolic syndrome ( 22399527 30382898 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 19043545 22916037 23281178 23823483) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phosphatidylethanolamine levels ( 31551469) Phospholipid levels (plasma) ( 22359512) Postprandial triglyceride response ( 32603185) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Stroke ( 26089329) Total cholesterol levels ( 28334899 29403010 29615537 33339817) Triglyceride levels ( 28334899 29403010 30698716 31087446 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in HIV infection ( 33109212) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193043 20686565 24097068 25961943 26582766 30275531) Tumor necrosis factor levels ( 32805626)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Barrett's esophagus or Esophageal adenocarcinoma ( 31527586) Binge eating behaviour and bipolar disorder ( 24882193) Cardiovascular disease risk factors ( 21943158) Carotid intima media thickness ( 30510157) Cholesterol, total ( 19060911 20686565 24097068 25961943 26582766) Coronary artery disease ( 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Erectile dysfunction and prostate cancer treatment ( 20932654) Gastroesophageal reflux disease ( 31527586) HDL cholesterol ( 19060911 20686565 20864672 25961943 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 33339817) Hypertriglyceridemia ( 20657596) LDL (oxidized) ( 23247145) LDL cholesterol ( 18193043 18193044 18262040 19060906 19060910 19060911 20686565 20864672 21059979 21347282 23726366 24097068 24507774 25961943 26582766 26780889 30275531) LDL cholesterol levels ( 17463246 26690388 28334899 30698716 31087446 32203549 32759990) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels in HIV infection ( 33109212) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Lipid or lipoprotein levels ( 23696881) Lipoprotein (a) levels ( 33730874) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302) Low density lipoprotein cholesterol levels ( 33339817) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 31589552) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Non-HDL cholesterol levels ( 32902719) Oxidized LDL cholesterol levels ( 31150472) Pancreatic cancer ( 30206226) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 30224653) Red cell distribution width ( 32888494) Response to statin therapy ( 20339536) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 26690388 28334899 30275531 30718733 31087446 32902719 33339817) Triglyceride levels ( 29403010 32154731 32203549 33339817) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 18193044 19060906 19060911 20686565 20864672 25961943 26160806)
Interacting Genes		3 interacting genes: ADHFE1 APOB LRP1	25 interacting genes: AKT2 APOA1 ARFGAP1 BGN CALR CANX CD36 HSP90AA1 HSP90B1 HSPA1A HSPA5 HSPA8 LDLR LIPC LRP2 LRP6 MDM2 MTTP PDIA4 PPIB PRDX4 SEC61A2 SEC61B SMAD3 TREM2
Entrez ID		3990	338
HPRD ID		01058	00133
Ensembl ID		ENSG00000166035	ENSG00000084674
Uniprot IDs		A6H8L5 P11150	A0AAG2UUW0 P04114 Q59HB3 Q7Z7Q0
PDB IDs			9BD1 9BD8 9BDE 9BDT 9COO 9E9R 9EA7 9EAG
Enriched GO Terms of Interacting Partners?		Lipoprotein Transport Artery Morphogenesis Cellular Response To Amyloid-beta Response To Amyloid-beta Blood Vessel Morphogenesis Mature Chylomicron Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity L-glutamate Catabolic Process Via 2-hydroxyglutarate Hydroxyacid-oxoacid Transhydrogenase Activity Lipid Metabolic Process Chylomicron Remnant Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Triglyceride Mobilization Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Intermediate-density Lipoprotein Particle Positive Regulation Of Lysosomal Protein Catabolic Process Tube Morphogenesis Early Endosome Lipoprotein Biosynthetic Process Positive Regulation Of Cholesterol Storage Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis L-glutamate Catabolic Process Lipase Binding Clathrin Heavy Chain Binding Alcohol Dehydrogenase (NAD+) Activity Very-low-density Lipoprotein Particle Assembly Regulation Of Lysosomal Protein Catabolic Process Lipoprotein Catabolic Process Chylomicron Low-density Lipoprotein Particle Low-density Lipoprotein Particle Clearance Plasma Membrane Protein Complex Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Endocytic Vesicle Lumen Astrocyte Activation Heparan Sulfate Proteoglycan Binding Apolipoprotein Binding	Unfolded Protein Binding Protein Folding Intracellular Protein Localization Endoplasmic Reticulum Lumen Lipoprotein Particle Binding Protein Folding Chaperone Establishment Of Protein Localization Protein Transport Regulation Of Protein Stability ATP-dependent Protein Folding Chaperone Protein Folding In Endoplasmic Reticulum Low-density Lipoprotein Particle Receptor Activity Catabolic Process Melanosome Protein Catabolic Process Low-density Lipoprotein Particle Binding Endocytic Vesicle Lumen Response To Endoplasmic Reticulum Stress Protein Stabilization Amyloid-beta Metabolic Process Endoplasmic Reticulum Amyloid-beta Clearance Cholesterol Import Plasma Lipoprotein Particle Clearance Protein Refolding Macromolecule Catabolic Process Sterol Transport Amyloid-beta Clearance By Cellular Catabolic Process Post-translational Protein Targeting To Membrane, Translocation Ubiquitin Protein Ligase Binding ERAD Pathway Cellular Response To Lipoprotein Particle Stimulus High-density Lipoprotein Particle Binding Endoplasmic Reticulum Chaperone Complex Positive Regulation Of Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Catabolic Process Brush Border Membrane Regulation Of Defense Response Protein Metabolic Process Response To Hormone Apolipoprotein Binding Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Heat Shock Protein Binding Cell Surface Regulation Of Programmed Cell Death Cholesterol Transport Negative Regulation Of Programmed Cell Death
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