ARHGAP6 and TEC

		ARHGAP6	TEC
Description		Rho GTPase activating protein 6	tec protein tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Actin Cytoskeleton Mitotic Spindle	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity Phospholipase Activator Activity SH3 Domain Binding Phospholipase Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Actin Filament Organization Signal Transduction Rho Protein Signal Transduction Actin Filament Polymerization Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Intracellular Signal Transduction	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		RHOA GTPase cycle RAC3 GTPase cycle	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016)	Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		2 interacting genes: LNX1 MAP1LC3A	37 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		395	7006
HPRD ID		02124	02786
Ensembl ID		ENSG00000047648	ENSG00000135605
Uniprot IDs		O43182 Q59HG6	P42680
PDB IDs			2LUL
Enriched GO Terms of Interacting Partners?		Phospholipid Binding Response To Iron(II) Ion Response To Oxygen-glucose Deprivation Cellular Response To Oxygen-glucose Deprivation Autolysosome Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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