WEE2-AS1 and USP1

Number of citations of the paper that reports this interaction (PubMedID 36123327)
40

Data Source:
BioGRID (unspecified method)

		WEE2-AS1	USP1
Description		WEE2 antisense RNA 1	ubiquitin specific peptidase 1
Image		No pdb structure
GO Annotations	Cellular Component	U1 SnRNP	Nucleus Nucleoplasm Cytosol
	Molecular Function	Pre-mRNA 5'-splice Site Binding	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	MRNA 5'-splice Site Recognition	Skeletal System Development DNA Repair Regulation Of DNA Repair Proteolysis DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To UV Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Error-prone Translesion Synthesis
Pathways			Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
Drugs
Diseases
GWAS			Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Red blood cell count ( 32888494) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels ( 32203549) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1	20 interacting genes: BCAT2 DTX3 EZH2 EZR FANCD2 FANCI KLHDC2 MAX MYC NMRAL1 PARP1 PHF7 TAGLN TRAF6 TRIM46 UBB UBC UBE2K WDR48 WEE2-AS1
Entrez ID		285962	7398
HPRD ID		08286	04593
Ensembl ID		ENSG00000228775	ENSG00000162607
Uniprot IDs			O94782
PDB IDs			6DO5 7AY0 7AY1 7AY2 7ZH3 7ZH4 8A9J 8A9K 9EBS 9FCI 9FCJ 9HNW
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization	Myc-Max Complex Nucleoplasm Ubiquitin Protein Ligase Binding Regulation Of Protein Monoubiquitination Post-translational Protein Modification Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Protein Modification Process Regulation Of Protein Modification Process Protein Ubiquitination Regulation Of Protein Ubiquitination Protein Modification By Small Protein Conjugation DNA Repair Complex Ubiquitin-ubiquitin Ligase Activity Regulation Of Post-translational Protein Modification Protein Tag Activity DNA Damage Response Positive Regulation Of Protein Metabolic Process Seminiferous Tubule Development Positive Regulation Of Protein Ubiquitination Protein Modification Process Animal Organ Morphogenesis DNA Polymerase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of DNA-templated Transcription, Elongation Modification-dependent Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Binding NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Chromatin NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Nuclear Body NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of MAP Kinase Activity Hepatocyte Homeostasis Regulation Of Kidney Development Regulation Of Protein Metabolic Process Anatomical Structure Morphogenesis Interstrand Cross-link Repair Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Positive Regulation Of Signal Transduction By P53 Class Mediator Vesicle Protein-DNA Complex
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