WEE2-AS1 and FLG

Number of citations of the paper that reports this interaction (PubMedID 36123327)
40

Data Source:
BioGRID (unspecified method)

		WEE2-AS1	FLG
Description		WEE2 antisense RNA 1	filaggrin
Image		No pdb structure
GO Annotations	Cellular Component	U1 SnRNP	Cornified Envelope Nucleus Cytosol Extracellular Matrix Keratohyalin Granule Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Pre-mRNA 5'-splice Site Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Skin Epidermis Metal Ion Binding Transition Metal Ion Binding
	Biological Process	MRNA 5'-splice Site Recognition	Peptide Cross-linking Keratinocyte Differentiation Establishment Of Skin Barrier
Pathways			Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases			Ichthyosis vulgaris
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 30929738 34103634 32296059 31959851 31619474 31361310) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 21666691 26482879 25574825 23886662) Atopic march ( 26542096) Eating disorders ( 23568457) Eczema ( 31361310) Male-pattern baldness ( 28196072)
Interacting Genes		161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1	5 interacting genes: CSNK2A1 PCSK6 UBXN7 UCHL5 WEE2-AS1
Entrez ID		285962	2312
HPRD ID		08286	15920
Ensembl ID		ENSG00000228775	ENSG00000143631
Uniprot IDs			P20930
PDB IDs			4PCW
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization	Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Protein Catabolic Process Nerve Growth Factor Production Zygotic Determination Of Anterior/posterior Axis, Embryo Protein Kinase CK2 Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Pre-mRNA 5'-splice Site Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Aggrephagy Nerve Growth Factor Binding Macromolecule Catabolic Process Regulation Of DNA Repair DNA Recombination MRNA 5'-splice Site Recognition VCP-NPL4-UFD1 AAA ATPase Complex Forebrain Morphogenesis Proteolysis Anterior/posterior Axis Specification, Embryo Double-strand Break Repair Via Classical Nonhomologous End Joining Aggrephagy Protein Targeting To Vacuole Involved In Autophagy Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Protein Metabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage Lateral Ventricle Development Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of DNA Strand Elongation Ino80 Complex MRNA Methylguanosine-cap Decapping Proteasome Binding U1 SnRNP RNA Decapping Sin3-type Complex Peptidase Activity
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