WEE2-AS1 and FLG2

Number of citations of the paper that reports this interaction (PubMedID 36123327)
40

Data Source:
BioGRID (unspecified method)

		WEE2-AS1	FLG2
Description		WEE2 antisense RNA 1	filaggrin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	U1 SnRNP	Cornified Envelope Extracellular Region Nucleus Cytoplasm Keratohyalin Granule Tertiary Granule Lumen
	Molecular Function	Pre-mRNA 5'-splice Site Binding	Structural Molecule Activity Calcium Ion Binding Metal Ion Binding Transition Metal Ion Binding
	Biological Process	MRNA 5'-splice Site Recognition	Cell Adhesion Epidermis Morphogenesis Establishment Of Skin Barrier
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474 31959851) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Eating disorders ( 23568457) Systemic sclerosis ( 33069728)
Interacting Genes		161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1	3 interacting genes: HSP90AA1 USP7 WEE2-AS1
Entrez ID		285962	388698
HPRD ID		08286	11815
Ensembl ID		ENSG00000228775	ENSG00000143520
Uniprot IDs			Q5D862
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization	Rho GDP-dissociation Inhibitor Binding CTP Binding Protein Stabilization DATP Binding Neurofibrillary Tangle Assembly Regulation Of Intracellular Transport Protein-RNA Complex Assembly UTP Binding Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Sulfonylurea Receptor Binding Symbiont-mediated Disruption Of Host Cell PML Body Pre-mRNA 5'-splice Site Binding Chaperone-mediated Autophagy Sperm Mitochondrial Sheath Nitric-oxide Synthase Regulator Activity Regulation Of Protein Catabolic Process Regulation Of Protein Stability Dendritic Growth Cone Sperm Plasma Membrane TPR Domain Binding Telomerase Holoenzyme Complex Assembly Regulation Of Establishment Of Protein Localization To Chromosome Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi MRNA 5'-splice Site Recognition Positive Regulation Of Cardiac Muscle Contraction Inclusion Body Assembly Monoubiquitinated Protein Deubiquitination Positive Regulation Of Cell Size Protein Unfolding DNA Alkylation Repair Transcription-coupled Nucleotide-excision Repair Regulation Of DNA Metabolic Process Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Striated Muscle Contraction Striated Muscle Cell Apoptotic Process Regulation Of Telomere Capping Regulation Of Cellular Localization Cellular Component Assembly Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Establishment Of Protein Localization Enzyme-substrate Adaptor Activity Endocytic Vesicle Lumen Positive Regulation Of Catabolic Process Response To Salt Stress Muscle Cell Apoptotic Process Negative Regulation Of Gluconeogenesis K48-linked Deubiquitinase Activity U1 SnRNP
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