WEE2-AS1 and TANK

Number of citations of the paper that reports this interaction (PubMedID 36168628)
47

Data Source:
BioGRID (unspecified method)

		WEE2-AS1	TANK
Description		WEE2 antisense RNA 1	TRAF family member associated NFKB activator
Image		No pdb structure
GO Annotations	Cellular Component	U1 SnRNP	Cytoplasm Cytosol Protein-containing Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Pre-mRNA 5'-splice Site Binding	Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Deubiquitinase Activator Activity Metal Ion Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity
	Biological Process	MRNA 5'-splice Site Recognition	DNA Damage Response Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ionizing Radiation Positive Regulation Of Protein Deubiquitination Positive Regulation Of Ubiquitin-specific Protease Activity
Pathways			TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
GWAS			Alcohol consumption ( 27911795) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Dietary macronutrient intake ( 23372041) Educational attainment ( 25201988) Educational attainment (years of education) ( 23722424) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Obesity-related traits ( 23251661) Presence of antiphospholipid antibodies ( 23509613) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Smoking status (ever vs never smokers) ( 30643258) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Subcutaneous adipose tissue ( 22589738) Tourette syndrome ( 30818990) Treatment response for severe sepsis ( 22310353) Weight ( 31647587)
Interacting Genes		161 interacting genes: AASS ACSL3 ACTG1 AGAP1 AHNAK AJUBA AKAP11 ALB ALKBH4 ANXA2 ARL6IP4 ASPSCR1 ATAD3A BCLAF1 BRAT1 CALML5 CLPB COPB2 COPG1 CSTF1 CTNND1 CTU2 DAXX DDX1 DDX23 DIDO1 DLST DNAAF5 DOHH DPYSL4 DSC1 DSP EEF1A1 EGR2 EIF3A ELL EMD EPM2AIP1 ERAP1 ERH EXOC4 FAM120B FAM83H FLG FLG2 FMR1 FOXK1 FXR1 FXR2 GAB1 GAPDH GBF1 GNL3 GRB10 GSDME GSN GTF3C1 GTPBP1 GTSE1 HARS1 HAX1 HMGA1 HMGCS1 HNRNPA2B1 HNRNPC HNRNPH1 HNRNPH2 HNRNPLL HNRNPM HSP90AA1 HSP90AB1 HSPA6 HSPA8 HSPB1 IFIT1 IGF2BP1 IGF2BP3 KCTD3 KIF20A KIF22 LAMC1 LARP7 LDLR LUC7L2 MAGED2 MAP1A MED23 MINDY3 MOB1A MSH6 MYH9 MYO1C NCKAP1 NDFIP1 NEK9 NISCH NPM1 NUP160 NXF1 PABPC1 PALS2 PARP1 PCMT1 PDCD2L PDXP PIGU PJA2 PLEC POP1 PPL PPM1F PRKAR2A PSMB1 PSMD1 PTK2 QTRT2 RAB5A RAF1 RETREG2 RPL13 RPLP2 RPN2 RPP30 RPRD1B RPS17 RPS2 RPS28 RPS29 RPS8 S100A14 S100A7 SEC13 SERBP1 SHKBP1 SHTN1 SKIC2 SLC25A11 SLC27A3 SNX8 SQSTM1 SRP68 STAT5B TANK THBS1 THRAP3 TIMELESS TMPO TOR1AIP2 TPR TRIM21 TRIM56 TRMT10C TTC28 TUBA1B TUBB3 TUBB4B U2AF1 UBB USP1 XRCC6 YBX1	32 interacting genes: AIMP2 APBA3 APP ATP6V1H BIK CD40 CHUK COPB1 FBLN1 HLA-C IKBKB IKBKE IKBKG INPP5K KPNA2 LAMC1 MAP4K5 MARCHF5 RACGAP1 SDC4 SMAD3 SRSF11 TBK1 TP53BP2 TRAF1 TRAF2 TRAF3 TRAF6 TSC1 USP7 WEE2-AS1 ZC3H12A
Entrez ID		285962	10010
HPRD ID		08286	04870
Ensembl ID		ENSG00000228775	ENSG00000136560
Uniprot IDs			B2R7S3 Q6NW12 Q92844
PDB IDs			1KZZ 1L0A 5H10
Enriched GO Terms of Interacting Partners?		RNA Binding Cytosol Ribonucleoprotein Complex Cytoplasm Nucleus Focal Adhesion Extracellular Exosome Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Nucleic Acid Metabolic Process RNA Metabolic Process Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule MRNA Binding N6-methyladenosine-containing RNA Reader Activity Protein Binding MRNA Processing RNA Transport Nucleolus MRNA Transport Biological_process RNA Processing Nucleic Acid Binding Cellular Response To Heat Translation Regulator Activity Positive Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cornified Envelope Positive Regulation Of Macromolecule Metabolic Process MRNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Heat Regulation Of Translation Regulation Of MRNA Stability CRD-mediated MRNA Stabilization Ficolin-1-rich Granule Lumen MRNA 3'-UTR Binding Nucleobase-containing Compound Transport Regulation Of RNA Stability Negative Regulation Of MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Ubiquitin Protein Ligase Binding Structural Molecule Activity Positive Regulation Of Gene Expression RNA Splicing Cadherin Binding Negative Regulation Of MRNA Catabolic Process Regulation Of Plasma Membrane Organization	CD40 Receptor Complex Regulation Of Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Regulation Of Cytokine Production Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Immune Response Response To Virus Intracellular Signaling Cassette Non-canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction IkappaB Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Signal Transduction Positive Regulation Of Type I Interferon Production Positive Regulation Of Immune System Process Positive Regulation Of Cytokine Production Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Communication Response To Other Organism Regulation Of Signaling Immune Response-regulating Signaling Pathway Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Activation Of Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Activation Of Innate Immune Response Immune Response Positive Regulation Of Defense Response Positive Regulation Of Gene Expression Regulation Of Type I Interferon Production IkappaB Kinase Complex Regulation Of Defense Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Tumor Necrosis Factor Receptor Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Response To External Biotic Stimulus Signaling Adaptor Activity Positive Regulation Of Signal Transduction Immune System Process Pattern Recognition Receptor Signaling Pathway CD40 Signaling Pathway
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