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L1CAM and ITGA5
Number of citations of the paper that reports this interaction (PubMedID
10871287
)
65
Data Source:
HPRD
(in vitro)
L1CAM
ITGA5
Description
L1 cell adhesion molecule
integrin subunit alpha 5
Image
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Axon
Dendrite
Growth Cone
Extracellular Matrix
Cell Projection
Neuronal Cell Body
Axonal Growth Cone
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Membrane
Cell Junction
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Postsynaptic Membrane
Anchoring Junction
Alphav-beta3 Integrin-vitronectin Complex
Glutamatergic Synapse
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Virus Receptor Activity
Signaling Receptor Binding
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Signaling Receptor Activity
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Cell Differentiation
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Axon Development
Angiogenesis
Formation Of Primary Germ Layer
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Tissue Development
Positive Regulation Of Cell-substrate Adhesion
Response To Muscle Activity
CD40 Signaling Pathway
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Regulation Of Angiogenesis
Symbiont Entry Into Host Cell
Cell-cell Adhesion
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
GPER1 signaling
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Ethanol
Resveratrol
Tauroursodeoxycholic acid
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
Hereditary spastic paraplegia (SPG)
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
32 interacting genes:
ACKR5
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
VTN
Entrez ID
3897
3678
HPRD ID
02394
00627
Ensembl ID
ENSG00000198910
ENSG00000161638
Uniprot IDs
P32004
B2R627
P08648
PDB IDs
8AFO
8AFP
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
7NWL
7NXD
9B9J
9B9K
9CKV
Enriched GO Terms of Interacting Partners
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Postsynaptic Membrane
Semaphorin Receptor Complex
Semaphorin Receptor Activity
Cell Projection Organization
Regulation Of Cellular Component Organization
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Plasma Membrane
Plasma Membrane Bounded Cell Projection Organization
Hypothalamus Cell Migration
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Localization To Early Endosome
Signal Transduction
Semaphorin-plexin Signaling Pathway
Neuron Projection Guidance
Positive Regulation Of Protein Localization To Endosome
Glutamatergic Synapse
Cell Adhesion
Focal Adhesion
Cell Migration
Neuron Migration
Vestibulocochlear Nerve Structural Organization
Dorsal Root Ganglion Morphogenesis
Sensory Neuron Axon Guidance
Facioacoustic Ganglion Development
Regulation Of Early Endosome To Late Endosome Transport
Regulation Of Protein Metabolic Process
Neuron Projection Development
Regulation Of Transport
Regulation Of Cell Migration
ATPase Binding
Regulation Of Cell Motility
Ventral Trunk Neural Crest Cell Migration
Apical Part Of Cell
Cell Motility
Regulation Of Cell Communication
Regulation Of Locomotion
Cell Adhesion Molecule Binding
Microvillus Membrane
Gland Morphogenesis
Cell Periphery
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Signal Transduction
Intracellular Signal Transduction
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Sympathetic Neuron Projection Guidance
Trigeminal Ganglion Development
Axon Guidance
Regulation Of Anatomical Structure Morphogenesis
Basolateral Plasma Membrane
Membrane To Membrane Docking
Cell Adhesion
Integrin Binding
Cell-substrate Adhesion
Cell-matrix Adhesion
Regulation Of Cell Migration
Regulation Of Cell Motility
Regulation Of Locomotion
Angiogenesis
Anatomical Structure Formation Involved In Morphogenesis
Positive Regulation Of Cell Migration
Extracellular Matrix
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Cell Surface Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Cell Migration
Receptor Complex
Response To Growth Factor
Signal Transduction
Cell Adhesion Mediated By Integrin
Enzyme-linked Receptor Protein Signaling Pathway
Cell Motility
Extracellular Exosome
Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Cellular Response To Growth Factor Stimulus
Regulation Of Response To Wounding
Regulation Of ERK1 And ERK2 Cascade
Focal Adhesion
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of Cell Adhesion
Extracellular Space
Negative Regulation Of Blood Coagulation
Cell Junction Organization
Negative Regulation Of Hemostasis
Negative Regulation Of Coagulation
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Transmembrane Receptor Protein Tyrosine Kinase Activity
Mesodermal Cell Differentiation
Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Extracellular Region
Regulation Of Cell-substrate Adhesion
Regulation Of Anatomical Structure Morphogenesis
Platelet Alpha Granule Membrane
Protein Tyrosine Kinase Activity
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Population Proliferation
Regulation Of Wound Healing
Regulation Of Cell Population Proliferation
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Tagcloud (Difference)
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Tagcloud (Intersection)
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