L1CAM

Name	L1 cell adhesion molecule
Structure
Interactors	24 interactors: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Axon Dendrite Growth Cone Extracellular Matrix Cell Projection Neuronal Cell Body Axonal Growth Cone
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding
	Biological Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Cell Differentiation Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Axon Development
Pathways	Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1
Drugs	Ethanol
Diseases	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum Hereditary spastic paraplegia (SPG)
GWAS	No GWAS studies recorded
Entrez ID	3897
HPRD ID	02394
Ensembl ID	ENSG00000198910
Uniprot IDs	P32004
PDB IDs	8AFO 8AFP
GO Terms Enriched among Interactors ?	Postsynaptic Membrane Semaphorin Receptor Complex Semaphorin Receptor Activity Cell Projection Organization Regulation Of Cellular Component Organization Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Hypothalamus Cell Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Signal Transduction Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Positive Regulation Of Protein Localization To Endosome Glutamatergic Synapse Cell Adhesion Focal Adhesion Cell Migration Neuron Migration Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Early Endosome To Late Endosome Transport Regulation Of Protein Metabolic Process Neuron Projection Development Regulation Of Transport Regulation Of Cell Migration ATPase Binding Regulation Of Cell Motility Ventral Trunk Neural Crest Cell Migration Apical Part Of Cell Cell Motility Regulation Of Cell Communication Regulation Of Locomotion Cell Adhesion Molecule Binding Microvillus Membrane Gland Morphogenesis Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Intracellular Signal Transduction Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Axon Guidance Regulation Of Anatomical Structure Morphogenesis Basolateral Plasma Membrane Membrane To Membrane Docking