L1CAM and ANK2

Number of citations of the paper that reports this interaction (PMID 9832558)
31

Data Source:
HPRD (in vivo)

		L1CAM	ANK2
Gene Name		L1 cell adhesion molecule	ankyrin 2, neuronal
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Presynaptic Membrane Terminal Bouton	Intracellular Cytosol Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Neuron Projection Costamere Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Integrin Binding Sialic Acid Binding Identical Protein Binding Protein Self-association	Structural Constituent Of Cytoskeleton Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding
	Biological Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Blood Coagulation Positive Regulation Of Cell-cell Adhesion Cell-cell Adhesion Mediated By Integrin Homotypic Cell-cell Adhesion Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis Axon Guidance Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Protein Targeting To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Regulation Of Cardiac Muscle Cell Membrane Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity
Pathways		Interaction between L1 and Ankyrins Signal transduction by L1 Axon guidance L1CAM interactions Recycling pathway of L1 Basigin interactions Cell surface interactions at the vascular wall	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS			Blood trace element (Cu levels) ( 23720494) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		21 interactors: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR ITGA5 ITGAV MSN NCAM1 NCAN NRP1 NUMB PEA15 PRNP RABGEF1 RANBP9 RDX RPS6KA1 RPS6KA2 UBC	12 interactors: DNAJB1 EPB42 KIAA0368 L1CAM NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53
Entrez ID		3897	287
HPRD ID		02394	00110
Ensembl ID		ENSG00000198910	ENSG00000145362
Uniprot IDs		P32004	Q01484
PDB IDs			4D8O
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Neuron Development Locomotion Cell Morphogenesis Cell Development Neuron Differentiation Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Response To External Stimulus Cell Differentiation Nervous System Development Anatomical Structure Morphogenesis Anatomical Structure Development Regulation Of Cellular Component Organization Developmental Process System Development Multicellular Organismal Development Negative Regulation Of Apoptotic Process Endothelial Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Endothelium Development Regulation Of Cellular Component Movement Regulation Of Apoptotic Process Response To Stimulus Establishment Of Endothelial Barrier Regulation Of Cell Death Cell Adhesion Regulation Of Protein Metabolic Process Membrane To Membrane Docking Negative Regulation Of Protein Metabolic Process Regulation Of Cell Migration Endothelial Cell Development Regulation Of Cellular Process Regulation Of Cell Motility Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway	Regulation Of Cellular Component Organization Regulation Of Cell Growth Membrane Organization Nervous System Development Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cell Differentiation Generation Of Neurons Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Morphogenesis Neurogenesis Anatomical Structure Development Regulation Of Intracellular Signal Transduction Axonogenesis Cell Morphogenesis Cell Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cellular Component Assembly Cell Projection Organization Regulation Of Growth Developmental Process Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Morphogenesis System Development Regulation Of Neurogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Component Size Regulation Of Axon Extension Neuron Projection Development Cell Projection Morphogenesis Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Neuron Projection Development Axon Guidance Neuron Development Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Endomembrane System Organization Regulation Of Signal Transduction B Cell Differentiation Negative Regulation Of Helicase Activity Protein Localization To M-band Positive Regulation Of Cell Growth Regulation Of Cell Projection Organization Protein Import Into Nucleus Protein Localization Protein Metabolic Process Nuclear Import Neuron Differentiation
Tagcloud ?		advocate androgen ar atlas bad cancers causally chip cohorts displaying endometrial exclusively find heterogeneous immuno inversely lysates mb436 overlaps precipitation preferentially progesterone serous similarities though tnbcs turn worst	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Difference) ?		advocate androgen ar atlas bad cancers causally chip cohorts displaying endometrial exclusively find heterogeneous immuno inversely lysates mb436 overlaps precipitation preferentially progesterone serous similarities though tnbcs turn worst	absent eif2alpha encode failed hela indirect inhibit insufficient interestingly k1 longer measure modest modification necessary pkr portion possesses prevented productive replicate restoration rk13 s2c theory third vaccinia virus viruses
Tagcloud (Intersection) ?