L1CAM and RPS6KA2

Number of citations: 0 (PubMedID 8663493)
Data Source: HPRD (in vivo, in vitro)

		L1CAM	RPS6KA2
Name		L1 cell adhesion molecule	ribosomal protein S6 kinase A2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Cell Surface Membrane Axon Dendrite Growth Cone Extracellular Matrix Cell Projection Neuronal Cell Body Axonal Growth Cone	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Synapse Meiotic Spindle
	Molecular Function	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Cell Differentiation Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Axon Development	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Intracellular Signal Transduction TORC1 Signaling Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus
Pathways		Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Ethanol	None
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum Hereditary spastic paraplegia (SPG)	None
GWAS		No GWAS studies recorded	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134 ) Alzheimer's disease progression score ( 29860282 ) Bipolar disorder ( 31043756 34002096 ) Bipolar I disorder ( 31043756 ) Blood pressure (smoking interaction) ( 25189868 ) Café-au-lait macule number in neurofibromatosis type1 ( 32869517 ) Dental caries ( 23259602 ) HDL cholesterol levels in HIV infection ( 33109212 ) Inflammatory bowel disease ( 23128233 27569725 ) Macrovascular complications in type 2 diabetes ( 33430853 ) Pre-treatment viral load in HIV-1 infection ( 31219150 ) Smooth-surface caries ( 24556642 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Waist circumference ( 28552196 )
Novel Interactors		None recorded	7 novel interactors: AFDN DYNLT1 DYNLT2 KCNJ6 OTUD4 TBXT THBS2
Interacting Genes		24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2	12 interacting genes: BAD CREB1 FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1 TP53
Entrez ID		3897	6196
HPRD ID		02394	03403
Ensembl ID		ENSG00000198910	ENSG00000071242
Uniprot IDs		P32004	B7Z3B5 F2Z2J1 Q15349 X5D337
PDB IDs		8AFO 8AFP	Not available
GO Terms Enriched among Interactors		Postsynaptic Membrane Semaphorin Receptor Complex Semaphorin Receptor Activity Cell Projection Organization Regulation Of Cellular Component Organization Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Hypothalamus Cell Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Signal Transduction Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Positive Regulation Of Protein Localization To Endosome Glutamatergic Synapse Cell Adhesion Focal Adhesion Cell Migration Neuron Migration Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Early Endosome To Late Endosome Transport Regulation Of Protein Metabolic Process Neuron Projection Development Regulation Of Transport Regulation Of Cell Migration ATPase Binding Regulation Of Cell Motility Ventral Trunk Neural Crest Cell Migration Apical Part Of Cell Cell Motility Regulation Of Cell Communication Regulation Of Locomotion Cell Adhesion Molecule Binding Microvillus Membrane Gland Morphogenesis Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Intracellular Signal Transduction Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Axon Guidance Regulation Of Anatomical Structure Morphogenesis Basolateral Plasma Membrane Membrane To Membrane Docking	Regulation Of Golgi Inheritance Trachea Formation ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Bergmann Glial Cell Differentiation Regulation Of Golgi Organization Regulation Of Early Endosome To Late Endosome Transport Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Face Development Schwann Cell Development Animal Organ Formation ERBB2 Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Interleukin-34-mediated Signaling Pathway Hematopoietic Or Lymphoid Organ Development Lung Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Astrocyte Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Cellular Developmental Process Regulation Of Stress-activated MAPK Cascade Cell Differentiation Gland Development Anatomical Structure Morphogenesis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Multicellular Organismal Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Positive Regulation Of Cellular Component Organization Response To Lipid Cell Surface Receptor Signaling Pathway Response To Nicotine Transcription Factor AP-1 Complex Regulation Of Cell Development Thymus Development Intracellular Signaling Cassette Cardiac Neural Crest Cell Development Involved In Heart Development Response To Epidermal Growth Factor ERK1 And ERK2 Cascade Positive Regulation Of MiRNA Transcription Outer Ear Morphogenesis Identical Protein Binding Cellular Response To Starvation Positive Regulation Of MiRNA Metabolic Process Glial Cell Development Response To Mechanical Stimulus