L1CAM and RPS6KA2

Number of citations of the paper that reports this interaction (PMID 8663493)
21

Data Source:
HPRD (in vitro, in vivo)

		L1CAM	RPS6KA2
Gene Name		L1 cell adhesion molecule	ribosomal protein S6 kinase, 90kDa, polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Presynaptic Membrane Terminal Bouton	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Nuclear Membrane
	Molecular Function	Integrin Binding Sialic Acid Binding Identical Protein Binding Protein Self-association	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Blood Coagulation Positive Regulation Of Cell-cell Adhesion Cell-cell Adhesion Mediated By Integrin Homotypic Cell-cell Adhesion Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration	Oocyte Maturation Brain Renin-angiotensin System Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Signal Transduction Synaptic Transmission Axon Guidance Heart Development Negative Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Apoptotic Process Innate Immune Response Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus
Pathways		Interaction between L1 and Ankyrins Signal transduction by L1 Axon guidance L1CAM interactions Recycling pathway of L1 Basigin interactions Cell surface interactions at the vascular wall	Signaling by GPCR CREB phosphorylation Axon guidance Toll Like Receptor 7/8 (TLR7/8) Cascade Cellular Senescence CREB phosphorylation L1CAM interactions Recycling pathway of L1 CREB phosphorylation through the activation of Ras Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK RSK activation Activation of NMDA receptor upon glutamate binding and postsynaptic events MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ERK/MAPK targets Post NMDA receptor activation events Innate Immune System Signalling by NGF MAP kinase activation in TLR cascade TRIF-mediated TLR3/TLR4 signaling Senescence-Associated Secretory Phenotype (SASP) NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade ERK/MAPK targets Toll Like Receptor 3 (TLR3) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Transmission across Chemical Synapses Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Dental caries ( 23259602) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		21 interactors: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR ITGA5 ITGAV MSN NCAM1 NCAN NRP1 NUMB PEA15 PRNP RABGEF1 RANBP9 RDX RPS6KA1 RPS6KA2 UBC	12 interactors: BAD CREB1 CSNK2B FLNC FOS JUN L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 SHANK1
Entrez ID		3897	6196
HPRD ID		02394	03403
Ensembl ID		ENSG00000198910	ENSG00000071242
Uniprot IDs		P32004	F2Z2J1 Q15349
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Neuron Development Locomotion Cell Morphogenesis Cell Development Neuron Differentiation Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Response To External Stimulus Cell Differentiation Nervous System Development Anatomical Structure Morphogenesis Anatomical Structure Development Regulation Of Cellular Component Organization Developmental Process System Development Multicellular Organismal Development Negative Regulation Of Apoptotic Process Endothelial Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Endothelium Development Regulation Of Cellular Component Movement Regulation Of Apoptotic Process Response To Stimulus Establishment Of Endothelial Barrier Regulation Of Cell Death Cell Adhesion Regulation Of Protein Metabolic Process Membrane To Membrane Docking Negative Regulation Of Protein Metabolic Process Regulation Of Cell Migration Endothelial Cell Development Regulation Of Cellular Process Regulation Of Cell Motility Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Fc Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Regulation Of Golgi Inheritance Response To External Stimulus MAPK Cascade Immune Response-regulating Signaling Pathway Innate Immune Response Neuron Projection Development Response To Organonitrogen Compound Regulation Of Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Signal Transduction By Phosphorylation Neuron Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Golgi Organization Neuron Projection Morphogenesis Neuron Differentiation Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Organization Response To Cytokine Cell Morphogenesis Involved In Differentiation Axon Guidance Cell Development Regulation Of Early Endosome To Late Endosome Transport Cellular Response To Organic Substance
Tagcloud ?		advocate androgen ar atlas bad cancers causally chip cohorts displaying endometrial exclusively find heterogeneous immuno inversely lysates mb436 overlaps precipitation preferentially progesterone serous similarities though tnbcs turn worst	00e 31e atlas bioinformatics brca1 chek2 classes detrimental driving eoc germline guide hereditary hg histologic inherited lethal mll4 mutational ovarian predispose serous signature soc somatic sporadic stratifies subgroups therapeutics
Tagcloud (Difference) ?		advocate androgen ar bad cancers causally chip cohorts displaying endometrial exclusively find heterogeneous immuno inversely lysates mb436 overlaps precipitation preferentially progesterone similarities though tnbcs turn worst	00e 31e bioinformatics brca1 chek2 classes detrimental driving eoc germline guide hereditary hg histologic inherited lethal mll4 mutational ovarian predispose signature soc somatic sporadic stratifies subgroups therapeutics
Tagcloud (Intersection) ?		atlas serous