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L1CAM and RPS6KA2
Number of citations of the paper that reports this interaction (PubMedID
8663493
)
0
Data Source:
HPRD
(in vivo, in vitro)
L1CAM
RPS6KA2
Description
L1 cell adhesion molecule
ribosomal protein S6 kinase A2
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Axon
Dendrite
Growth Cone
Extracellular Matrix
Cell Projection
Neuronal Cell Body
Axonal Growth Cone
Nucleus
Nucleoplasm
Cytoplasm
Spindle
Cytosol
Synapse
Meiotic Spindle
Molecular Function
Protein Binding
Axon Guidance Receptor Activity
Protein Domain Specific Binding
Nucleotide Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Ribosomal Protein S6 Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Chemotaxis
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Cell-matrix Adhesion
Nervous System Development
Axon Guidance
Cell Migration
Cell Differentiation
Neuron Projection Development
Positive Regulation Of Axon Extension
Synapse Organization
Axon Development
Oocyte Maturation
Brain Renin-angiotensin System
Signal Transduction
Chemical Synaptic Transmission
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Cardiac Muscle Cell Apoptotic Process
Intracellular Signal Transduction
TORC1 Signaling
Positive Regulation Of Apoptotic Process
Negative Regulation Of Cell Cycle
Negative Regulation Of Meiotic Nuclear Division
Heart Contraction
Regulation Of Protein Processing
Cellular Response To Carbohydrate Stimulus
Pathways
Basigin interactions
L1CAM interactions
L1CAM interactions
Recycling pathway of L1
Recycling pathway of L1
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Signal transduction by L1
ERK/MAPK targets
CREB phosphorylation
Senescence-Associated Secretory Phenotype (SASP)
Senescence-Associated Secretory Phenotype (SASP)
Recycling pathway of L1
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
RSK activation
RSK activation
Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Ethanol
Diseases
Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum
Hereditary spastic paraplegia (SPG)
GWAS
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Alzheimer's disease progression score (
29860282
)
Bipolar disorder (
31043756
34002096
)
Bipolar I disorder (
31043756
)
Blood pressure (smoking interaction) (
25189868
)
Café-au-lait macule number in neurofibromatosis type1 (
32869517
)
Dental caries (
23259602
)
HDL cholesterol levels in HIV infection (
33109212
)
Inflammatory bowel disease (
23128233
27569725
)
Macrovascular complications in type 2 diabetes (
33430853
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Smooth-surface caries (
24556642
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Waist circumference (
28552196
)
Interacting Genes
24 interacting genes:
ANK1
ANK2
CNTN1
CNTN2
CSNK2A1
EZR
FGFR1
ITGA5
ITGAV
LINC00839
MSN
NCAM1
NCAN
NRP1
NRP2
NUMB
PEA15
PLXNA1
PLXNB1
PRNP
RANBP9
RDX
RPS6KA1
RPS6KA2
12 interacting genes:
BAD
CREB1
FLNC
FOS
JUN
L1CAM
MAGI1
MAP2K1
MAPK1
MAPK3
SHANK1
TP53
Entrez ID
3897
6196
HPRD ID
02394
03403
Ensembl ID
ENSG00000198910
ENSG00000071242
Uniprot IDs
P32004
B7Z3B5
F2Z2J1
Q15349
X5D337
PDB IDs
8AFO
8AFP
Enriched GO Terms of Interacting Partners
?
Postsynaptic Membrane
Semaphorin Receptor Complex
Semaphorin Receptor Activity
Cell Projection Organization
Regulation Of Cellular Component Organization
Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus
Plasma Membrane
Plasma Membrane Bounded Cell Projection Organization
Hypothalamus Cell Migration
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Localization To Early Endosome
Signal Transduction
Semaphorin-plexin Signaling Pathway
Neuron Projection Guidance
Positive Regulation Of Protein Localization To Endosome
Glutamatergic Synapse
Cell Adhesion
Focal Adhesion
Cell Migration
Neuron Migration
Vestibulocochlear Nerve Structural Organization
Dorsal Root Ganglion Morphogenesis
Sensory Neuron Axon Guidance
Facioacoustic Ganglion Development
Regulation Of Early Endosome To Late Endosome Transport
Regulation Of Protein Metabolic Process
Neuron Projection Development
Regulation Of Transport
Regulation Of Cell Migration
ATPase Binding
Regulation Of Cell Motility
Ventral Trunk Neural Crest Cell Migration
Apical Part Of Cell
Cell Motility
Regulation Of Cell Communication
Regulation Of Locomotion
Cell Adhesion Molecule Binding
Microvillus Membrane
Gland Morphogenesis
Cell Periphery
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Signal Transduction
Intracellular Signal Transduction
Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching
Sympathetic Neuron Projection Guidance
Trigeminal Ganglion Development
Axon Guidance
Regulation Of Anatomical Structure Morphogenesis
Basolateral Plasma Membrane
Membrane To Membrane Docking
Regulation Of Golgi Inheritance
Trachea Formation
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Bergmann Glial Cell Differentiation
Regulation Of Golgi Organization
Regulation Of Early Endosome To Late Endosome Transport
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Face Development
Schwann Cell Development
Animal Organ Formation
ERBB2 Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Interleukin-34-mediated Signaling Pathway
Hematopoietic Or Lymphoid Organ Development
Lung Morphogenesis
Transforming Growth Factor Beta Receptor Signaling Pathway
Thyroid Gland Development
Astrocyte Differentiation
Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Developmental Process
Regulation Of Stress-activated MAPK Cascade
Cell Differentiation
Gland Development
Anatomical Structure Morphogenesis
Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Multicellular Organismal Process
Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly
Caveolin-mediated Endocytosis
Positive Regulation Of Macrophage Proliferation
Positive Regulation Of Cellular Component Organization
Response To Lipid
Cell Surface Receptor Signaling Pathway
Response To Nicotine
Transcription Factor AP-1 Complex
Regulation Of Cell Development
Thymus Development
Intracellular Signaling Cassette
Cardiac Neural Crest Cell Development Involved In Heart Development
Response To Epidermal Growth Factor
ERK1 And ERK2 Cascade
Positive Regulation Of MiRNA Transcription
Outer Ear Morphogenesis
Identical Protein Binding
Cellular Response To Starvation
Positive Regulation Of MiRNA Metabolic Process
Glial Cell Development
Response To Mechanical Stimulus
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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