L1CAM and NCAM1

Number of citations of the paper that reports this interaction (PMID 8509458)
17

Data Source:
HPRD (in vitro)

		L1CAM	NCAM1
Gene Name		L1 cell adhesion molecule	neural cell adhesion molecule 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Presynaptic Membrane Terminal Bouton	Golgi Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Anchored Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Integrin Binding Sialic Acid Binding Identical Protein Binding Protein Self-association	Identical Protein Binding
	Biological Process	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Blood Coagulation Positive Regulation Of Cell-cell Adhesion Cell-cell Adhesion Mediated By Integrin Homotypic Cell-cell Adhesion Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration	Cell Adhesion Axon Guidance Cytokine-mediated Signaling Pathway Extracellular Matrix Organization Interferon-gamma-mediated Signaling Pathway
Pathways		Interaction between L1 and Ankyrins Signal transduction by L1 Axon guidance L1CAM interactions Recycling pathway of L1 Basigin interactions Cell surface interactions at the vascular wall	Interferon gamma signaling Signal transduction by L1 NCAM1 interactions Axon guidance ECM proteoglycans Interferon Signaling L1CAM interactions Cytokine Signaling in Immune system NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS			Entorhinal cortical thickness ( 21116278) Left ventricular mass ( 21212386)
Protein-Protein Interactions		21 interactors: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR ITGA5 ITGAV MSN NCAM1 NCAN NRP1 NUMB PEA15 PRNP RABGEF1 RANBP9 RDX RPS6KA1 RPS6KA2 UBC	19 interactors: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1
Entrez ID		3897	4684
HPRD ID		02394	00301
Ensembl ID		ENSG00000198910	ENSG00000149294
Uniprot IDs		P32004	P13591
PDB IDs			2E3V 2HAZ 2VKW 2VKX 3MTR
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Neuron Development Locomotion Cell Morphogenesis Cell Development Neuron Differentiation Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis Response To External Stimulus Cell Differentiation Nervous System Development Anatomical Structure Morphogenesis Anatomical Structure Development Regulation Of Cellular Component Organization Developmental Process System Development Multicellular Organismal Development Negative Regulation Of Apoptotic Process Endothelial Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Negative Regulation Of Cell Death Endothelium Development Regulation Of Cellular Component Movement Regulation Of Apoptotic Process Response To Stimulus Establishment Of Endothelial Barrier Regulation Of Cell Death Cell Adhesion Regulation Of Protein Metabolic Process Membrane To Membrane Docking Negative Regulation Of Protein Metabolic Process Regulation Of Cell Migration Endothelial Cell Development Regulation Of Cellular Process Regulation Of Cell Motility Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway	Axonogenesis Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Chemotaxis Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Movement Of Cell Or Subcellular Component Cell Projection Organization Generation Of Neurons Locomotion Neurogenesis Cell Development Response To External Stimulus Anatomical Structure Morphogenesis Nervous System Development System Development Multicellular Organismal Development Anatomical Structure Development Cell Differentiation Developmental Process Single-organism Behavior Ganglioside Biosynthetic Process Response To Stimulus N-glycan Processing Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Response To Growth Factor Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Ganglioside Metabolic Process Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Glycosphingolipid Biosynthetic Process Negative Regulation Of Signaling Regulation Of Signal Transduction Learning Or Memory Cognition Axon Target Recognition Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Oligosaccharide Metabolic Process
Tagcloud ?		advocate androgen ar atlas bad cancers causally chip cohorts displaying endometrial exclusively find heterogeneous immuno inversely lysates mb436 overlaps precipitation preferentially progesterone serous similarities though tnbcs turn worst	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Difference) ?		advocate androgen ar atlas bad cancers causally chip cohorts displaying endometrial exclusively find heterogeneous immuno inversely lysates mb436 overlaps precipitation preferentially progesterone serous similarities though tnbcs turn worst	abundant astrocytes basic bcan cg clustering differentiated diverse embryos enriched fbln2 forebrain foundation functionally glial itih3 mesenchymal nervous networks neural nsc nscs ontology regulators rich tnr transcriptomes vcan wnt
Tagcloud (Intersection) ?