KRT17 and SNAPIN

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		KRT17	SNAPIN
Description		keratin 17	SNAP associated protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Cell Periphery	Golgi Membrane Acrosomal Vesicle Manchette Cytoplasm Lysosome Lysosomal Membrane Golgi Apparatus Cytosol Synaptic Vesicle Membrane Secretory Granule Synaptic Vesicle Membrane BLOC-1 Complex Cytoplasmic Vesicle Synapse Perinuclear Region Of Cytoplasm Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm Microvesicle
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	SNARE Binding Protein Binding
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Growth Epithelial Cell Differentiation Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development	Intracellular Protein Transport Exocytosis Lysosome Organization Lysosomal Lumen Acidification Chemical Synaptic Transmission Neurotransmitter Secretion Anterograde Axonal Transport Retrograde Axonal Transport Endosome To Lysosome Transport Negative Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Neuron Projection Development Protein-containing Complex Localization Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Lysosome Localization Melanosome Organization Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Protein Maturation Establishment Of Vesicle Localization Regulation Of Lysosome Size Neuron Cellular Homeostasis Organelle Transport Along Microtubule Terminal Button Organization Autophagosome Maturation Late Endosome To Lysosome Transport Positive Regulation Of Late Endosome To Lysosome Transport Regulation Of Synaptic Vesicle Exocytosis
Pathways		Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells	Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS
Interacting Genes		12 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 NEIL3 SNAPIN TRIM69 ZDHHC17	103 interacting genes: ABI2 ACTN2 ATG14 ATP1A1 BANP BFSP1 BFSP2 BIN1 BLOC1S1 BLOC1S2 BLOC1S4 BLOC1S5 BLOC1S6 BNIPL C20orf202 CCDC102B CDC42BPA CEP170 CMYA5 CSNK1D DDR1 DENND1C DES DNM2 DOCK9 DST DTNBP1 DYRK3 DYSF EBAG9 EEF1G ELP1 ENO3 EXOC7 FAM114A1 FSD2 GPRASP1 GRIK1 HAP1 HMGB2 IKBIP IMMT KANK2 KAT5 KAT7 KIF5C KPNB1 KRT10 KRT15 KRT16 KRT17 KRT19 KRT20 KRT24 KRT26 LAMA2 LAMC1 LMNB1 LRP12 MACF1 MAPK14 MET MORC3 MTNR1A MYH14 MYH3 MYH7 NECAB2 NEDD9 NME7 NUP62CL PCYT1A PLAC9 PLEC PRKACA RABEP1 RABGEF1 RETREG1 RGS7 RNF13 SHBG SKA1 SMAD2 SMG1 SNAP23 SNAP25 SPAG5 SPP1 SPTB SPTBN1 ST7 TFIP11 TOMM70 TPM1 TPM2 TPM3 TPM4 TRIM63 TRPV1 TSG101 WASHC3 YWHAE YWHAZ
Entrez ID		3872	23557
HPRD ID		01019	06111
Ensembl ID		ENSG00000128422	ENSG00000143553
Uniprot IDs		Q04695 Q14666	O95295
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Ruffle Assembly Cellular Response To Gamma Radiation Intermediate Filament Anatomical Structure Morphogenesis Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Multivesicular Body, Internal Vesicle Lumen Response To Gamma Radiation Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Late Endosome To Lysosome Transport MCM Complex Binding Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Size Golgi Membrane Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of ERK1 And ERK2 Cascade Shc-EGFR Complex Cellular Response To Ionizing Radiation GTPase Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Insulin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Golgi Apparatus Regulation Of MiRNA Metabolic Process Positive Regulation Of Protein Kinase C Signaling Regulation Of Fibroblast Proliferation Epidermal Growth Factor Receptor Activity Phospholipase C Activator Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ruffle Membrane Positive Regulation Of Cold-induced Thermogenesis	Cytoskeleton Organization Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Organization Establishment Of Organelle Localization Intermediate Filament Supramolecular Fiber Organization Organelle Localization Structural Constituent Of Cytoskeleton BLOC-1 Complex Actin Filament Binding Synaptic Vesicle Transport Establishment Of Vesicle Localization Structural Molecule Activity Axo-dendritic Transport Axon Cytoplasm Axonal Transport Vesicle Localization Establishment Of Localization In Cell Anterograde Axonal Transport Cytosol Anterograde Synaptic Vesicle Transport Muscle Thin Filament Tropomyosin Structural Constituent Of Skin Epidermis Cytoplasm Transport Along Microtubule Vesicle Transport Along Microtubule Cellular Localization Cytoskeleton-dependent Intracellular Transport Vesicle Cytoskeletal Trafficking Regulation Of Cellular Component Organization Microtubule-based Transport Melanosome Organization Keratin Filament Intracellular Transport Pigment Granule Organization Structural Constituent Of Muscle Actomyosin Structure Organization Muscle System Process Actin Binding Muscle Contraction Extracellular Exosome Contractile Muscle Fiber Stress Fiber Organelle Transport Along Microtubule Tissue Morphogenesis Intracellular Protein Localization Z Disc
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