KRT17

Description		keratin 17
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Cell Periphery
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Growth Epithelial Cell Differentiation Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development
Pathways		Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells
Drugs
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS
Novel Interacting Genes		1 novel interacting genes: EVL
Interacting Genes		12 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 NEIL3 SNAPIN TRIM69 ZDHHC17
Entrez ID		3872
HPRD ID		01019
Ensembl ID		ENSG00000128422
Uniprot IDs		Q04695 Q14666
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Ruffle Assembly Cellular Response To Gamma Radiation Intermediate Filament Anatomical Structure Morphogenesis Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Multivesicular Body, Internal Vesicle Lumen Response To Gamma Radiation Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Late Endosome To Lysosome Transport MCM Complex Binding Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Size Golgi Membrane Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of ERK1 And ERK2 Cascade Shc-EGFR Complex Cellular Response To Ionizing Radiation GTPase Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Insulin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Golgi Apparatus Regulation Of MiRNA Metabolic Process Positive Regulation Of Protein Kinase C Signaling Regulation Of Fibroblast Proliferation Epidermal Growth Factor Receptor Activity Phospholipase C Activator Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ruffle Membrane Positive Regulation Of Cold-induced Thermogenesis
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