KRT17 and KRT72

Number of citations of the paper that reports this interaction (PubMedID 29859926)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		KRT17	KRT72
Description		keratin 17	keratin 72
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Cytosol Cytoskeleton Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Cell Periphery	Cytosol Intermediate Filament Keratin Filament Extracellular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Growth Epithelial Cell Differentiation Hair Follicle Morphogenesis Keratinization Intermediate Filament Organization Positive Regulation Of Translation Positive Regulation Of Hair Follicle Development	Keratinization Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells	Keratinization Formation of the cornified envelope
Drugs
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS			High density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		12 interacting genes: APC CCDC85B EGFR HRAS KDM1A KRT6A KRT7 KRT72 NEIL3 SNAPIN TRIM69 ZDHHC17	25 interacting genes: BLOC1S6 HSPB1 KRT13 KRT14 KRT15 KRT16 KRT17 KRT18 KRT19 KRT20 KRT24 KRT25 KRT26 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 UBC
Entrez ID		3872	140807
HPRD ID		01019	09746
Ensembl ID		ENSG00000128422	ENSG00000170486
Uniprot IDs		Q04695 Q14666	B4DXK4 Q14CN4
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Keratinization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Regulation Of Cellular Component Organization Regulation Of Ruffle Assembly Cellular Response To Gamma Radiation Intermediate Filament Anatomical Structure Morphogenesis Supramolecular Fiber Organization Regulation Of Cell Projection Assembly Multivesicular Body, Internal Vesicle Lumen Response To Gamma Radiation Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of Late Endosome To Lysosome Transport MCM Complex Binding Positive Regulation Of Fibroblast Proliferation Regulation Of Cellular Component Size Golgi Membrane Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Cellular Component Organization Perinuclear Region Of Cytoplasm Regulation Of ERK1 And ERK2 Cascade Shc-EGFR Complex Cellular Response To Ionizing Radiation GTPase Complex Negative Regulation Of Entry Of Bacterium Into Host Cell Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Insulin Receptor Signaling Pathway Positive Regulation Of Cell Projection Organization Golgi Apparatus Regulation Of MiRNA Metabolic Process Positive Regulation Of Protein Kinase C Signaling Regulation Of Fibroblast Proliferation Epidermal Growth Factor Receptor Activity Phospholipase C Activator Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ruffle Membrane Positive Regulation Of Cold-induced Thermogenesis	Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Morphogenesis Of An Epithelium Epithelial Cell Differentiation Cytoskeleton Organization Tissue Morphogenesis Cytoskeleton Organelle Organization Anatomical Structure Morphogenesis Extracellular Exosome Cytosol Cell Differentiation Cellular Developmental Process Hair Cycle Intermediate Filament Cytoskeleton Structural Constituent Of Cytoskeleton Developmental Process Keratinization Epidermis Development Hair Follicle Morphogenesis Cornified Envelope Tissue Development Hair Cycle Process Cell Periphery Keratin Filament Binding Negative Regulation Of Protein Kinase C Signaling Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle
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