KRTAP10-8 and ECE1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP10-8	ECE1
Description		keratin associated protein 10-8	endothelin converting enzyme 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Lysosomal Membrane Endosome Early Endosome Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Membrane Vesicle Weibel-Palade Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Peptide Hormone Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process		Positive Regulation Of Receptor Recycling Regulation Of Systemic Arterial Blood Pressure By Endothelin Proteolysis Signal Transduction G Protein-coupled Receptor Signaling Pathway Axon Guidance Heart Development Anatomical Structure Morphogenesis Gene Expression Substance P Catabolic Process Bradykinin Catabolic Process Calcitonin Catabolic Process Protein Processing Peptide Hormone Processing Regulation Of Vasoconstriction Neuron Projection Development Endothelin Maturation Embryonic Heart Tube Development Hormone Catabolic Process Embryonic Digit Morphogenesis Ear Development Pharyngeal System Development Axonogenesis Involved In Innervation Sympathetic Neuron Axon Guidance Semaphorin-plexin Signaling Pathway Involved In Axon Guidance
Pathways		Keratinization	Peptide ligand-binding receptors
Drugs			5-(2-hydroxyethyl)nonane-1,9-diol
Diseases
GWAS			Appendicular lean mass ( 33097823) Body mass index ( 28552196) Body size at age 10 ( 32376654) Feeling worry ( 29500382) Height ( 25282103) Longevity (age >90th survival percentile) ( 31413261) Morning person ( 30696823) Obesity-related traits ( 23251661) Weight ( 28552196)
Interacting Genes		400 interacting genes: ACY3 ADAM12 ADAMTS1 ADAMTSL3 ADAMTSL4 AEBP2 AEN AK3 ALDH3B1 ALPI ALPP AMMECR1 ANKS1A ANXA2R-AS1 AP1M1 APOL6 AQP1 AREG ARHGAP33 ARID5A ASPSCR1 ATG9A ATP5F1D AVPI1 AXIN2 BAHD1 BCL6B BEX2 BMP7 BRME1 C10orf62 C11orf87 C17orf50 C19orf25 C22orf39 C2orf68 C3 CAMK1G CARD10 CARHSP1 CATSPER1 CCDC26 CCNJL CHIC2 CHRD CHRNG CLK4 CNNM3 COL8A1 COX17 CRCT1 CREB5 CRH CRY2 CSF1 CST2 CTRC CYP2S1 CYSRT1 DAAM2 DCX DDX43 DDX55 DDX6 DERL2 DHRS1 DHX57 DMRT3 DOCK2 ECE1 EFEMP2 EIF4E2 ENKD1 EPDR1 FADS6 FAH FAM110A FAM161A FAM221B FAM27E3 FAM74A4 FAM76B FAM90A1 FARS2 FBXO34 FBXW5 FEZF1 FOXB1 FRS3 FTHL17 FZD10 GARIN6 GEM GFOD1 GLIDR GLP1R GLRX3 GLYAT GNAI2 GNE GOLGA8EP GPANK1 GPHB5 GPRIN2 GRN GUCD1 HAPLN2 HCK HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HS6ST1 HSD3B7 HSPA12B HSPD1 ICAM1 IGFBP6 IGSF8 IL10 IL16 IL2RG INO80B INS INTS5 IP6K3 ITGB2 ITGB4 ITGB5 JOSD1 JPH3 KCNS2 KLHL38 KLK8 KPRP KRT20 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP13-2 KRTAP15-1 KRTAP17-1 KRTAP19-7 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 KSR2 LAGE3 LASP1 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LENG1 LINC00656 LMF2 LNX1 LRCH4 LRFN4 LUZP4 LYVE1 MACROH2A1 MAPKBP1 MATN3 MEIS2 MELTF MEOX2 MLLT6 MOBP MTA1 MTNR1A MUL1 MXD3 MXI1 MYPOP NAB2 NAXD NBPF19 NECTIN2 NECTIN3 NEK6 NKD1 NOTCH2NLA NPDC1 NR1D2 NR4A3 NTN4 NUFIP2 OLIG3 OPCML OTX1 P2RX7 P2RY6 PAX5 PCED1A PCSK5 PDE9A PDIA4 PGAP6 PGLS PHLDA1 PIGS PIN1 PKD2 PLA2G10 PLSCR4 POM121L8P POU1F1 POU4F2 PRF1 PRKAB2 PRPF31 PRR13 PRR19 PTGER3 PTK7 PTPMT1 PTPRH PVR QPRT R3HDM2 RAB19 RAB3A RALGDS RANBP3 RASD1 RECK RGL2 RHBDL1 RHNO1 RNF38 RNF8 RPS19BP1 RPS28 RTN4RL1 SCARF1 SCNM1 SEMA3B SH3GLB2 SHFL SLC13A5 SLC22A23 SLC23A1 SLC25A10 SLC25A31 SLC25A42 SLC6A20 SLIT1 SMARCE1 SMCP SMG9 SMOC1 SPACA9 SPAG8 SPATA24 SPATA3 SPRY1 SPRY2 SSC4D STK16 SUSD2 SUSD6 SUV39H1 TACSTD2 TAPBPL TBC1D16 TBC1D23 TCAF1 TCEA2 TCEANC TFAP2D TGFB1 THAP10 THAP7 TIE1 TLE5 TMEM140 TMEM150A TMIE TNIP3 TNP2 TNPO3 TNS2 TRIM41 TRIM42 TRPV6 TSPAN4 TTC23 TXNDC5 TYMSOS TYRO3 UBL5 UTP23 UXT VASN VENTX VEZF1 VGLL3 VPS11 VWC2 VWC2L WIF1 WNT11 WT1 WT1-AS YIPF3 YY1 ZBTB24 ZBTB25 ZDHHC1 ZFYVE21 ZIC1 ZNF101 ZNF107 ZNF121 ZNF124 ZNF138 ZNF165 ZNF20 ZNF23 ZNF250 ZNF264 ZNF266 ZNF319 ZNF32 ZNF330 ZNF408 ZNF414 ZNF417 ZNF419 ZNF439 ZNF440 ZNF444 ZNF473 ZNF490 ZNF491 ZNF497 ZNF524 ZNF559 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF625 ZNF648 ZNF669 ZNF696 ZNF697 ZNF775 ZNF786 ZNF79 ZNF792 ZNF837 ZSCAN12 ZSCAN21	14 interacting genes: AGT CALCA CLK1 CLK2 CYSRT1 EDN1 KNG1 KRTAP1-3 KRTAP10-1 KRTAP10-5 KRTAP10-8 MTDH MTNR1A MYOC
Entrez ID		386681	1889
HPRD ID		11194	02690
Ensembl ID		ENSG00000187766	ENSG00000117298
Uniprot IDs		P60410	P42892
PDB IDs			3DWB
Enriched GO Terms of Interacting Partners?		Intermediate Filament Protein Binding Keratin Filament Keratinization Epidermis Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Zinc Ion Binding DNA Binding Regulation Of Transcription By RNA Polymerase II Hair Cycle Tissue Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Axis Elongation Sequence-specific Double-stranded DNA Binding	Keratin Filament Hormone Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Intermediate Filament Skeletal Muscle Adaptation Regulation Of Renal Sodium Excretion Vascular Process In Circulatory System Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Renal Sodium Ion Transport Receptor Ligand Activity Renal Sodium Ion Absorption Circulatory System Process Positive Regulation Of Extracellular Matrix Organization Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Vasoconstriction Regulation Of Blood Pressure Positive Regulation Of Cardiac Muscle Hypertrophy Response To Testosterone Renal Absorption Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Response To Dexamethasone Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelin A Receptor Binding Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Rhythmic Excitation Skeletal Muscle Hypertrophy G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger System Process Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of Coagulation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Muscle Cell Apoptotic Process Cellular Response To Glucocorticoid Stimulus Regulation Of Muscle System Process Regulation Of Smooth Muscle Contraction Muscle System Process Regulation Of Extracellular Matrix Organization Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Membrane Hyperpolarization Negative Regulation Of Cation Transmembrane Transport G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Type 2 Angiotensin Receptor Binding Regulation Of Monoatomic Cation Transmembrane Transport
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