KRTAP10-8 and PKD2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KRTAP10-8	PKD2
Gene Name		keratin associated protein 10-8	polycystic kidney disease 2 (autosomal dominant)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Keratin Filament	Polycystin Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Cilium Basal Plasma Membrane Lamellipodium Motile Primary Cilium Nonmotile Primary Cilium Filamentous Actin Ciliary Basal Body Basal Cortex Ciliary Membrane Extracellular Vesicular Exosome Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Mitotic Spindle
	Molecular Function		Receptor Binding Voltage-gated Ion Channel Activity Voltage-gated Calcium Channel Activity Voltage-gated Sodium Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Voltage-gated Cation Channel Activity Identical Protein Binding Protein Homodimerization Activity Actinin Binding HLH Domain Binding Ion Channel Binding Calcium-induced Calcium Release Activity ATPase Binding Phosphoprotein Binding Muscle Alpha-actinin Binding
	Biological Process		Branching Involved In Ureteric Bud Morphogenesis Liver Development Embryonic Placenta Development Heart Looping Detection Of Nodal Flow Calcium Ion Transport Cell Cycle Arrest JAK-STAT Cascade Determination Of Left/right Symmetry Heart Development Negative Regulation Of Cell Proliferation Spinal Cord Development Neural Tube Development Regulation Of CAMP Metabolic Process Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Reactive Oxygen Species Metanephric Part Of Ureteric Bud Development Sodium Ion Transmembrane Transport Aorta Development Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Detection Of Mechanical Stimulus Release Of Sequestered Calcium Ion Into Cytosol Centrosome Duplication Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Placenta Blood Vessel Development Renal Tubule Morphogenesis Renal Artery Morphogenesis Calcium Ion Transmembrane Transport Positive Regulation Of Cell Cycle Arrest Cellular Response To Hydrostatic Pressure Cellular Response To Osmotic Stress Cellular Response To Fluid Shear Stress Potassium Ion Transmembrane Transport Determination Of Liver Left/right Asymmetry Metanephric Mesenchyme Development Mesonephric Tubule Development Mesonephric Duct Development Metanephric Smooth Muscle Tissue Development Metanephric Cortex Development Metanephric Ascending Thin Limb Development Metanephric Cortical Collecting Duct Development Metanephric Distal Tubule Development Metanephric S-shaped Body Morphogenesis Regulation Of Calcium Ion Import Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance VxPx cargo-targeting to cilium Assembly of the primary cilium
Drugs
Diseases
GWAS			Dental caries ( 23064961)
Protein-Protein Interactions		163 interactors: ACY3 ADAMTSL3 ADAMTSL4 AEN AES ALDH3B1 ALPI APOL6 ASPSCR1 ATG9A BEX2 BMP7 C11orf87 C19orf66 C9orf9 CARHSP1 CARKD CATSPER1 CCDC26 CCNJL CHIC2 CHRD CHRNG CLK4 CNNM3 COL8A1 CRCT1 CREB5 DAAM2 DCX DDX55 DDX6 DERL2 DHRS1 DHX57 DMRT3 DOCK2 EIF4E2 FAH FAM27E3 FAM74A4 FAM76B FBXW5 FOXB1 GFOD1 GLIDR GLP1R GLRX3 GLYAT GNAI2 GNE GOLGA8EP HHEX HOXA1 HPCAL1 HSD3B7 HSPD1 IGSF8 ITGB5 JOSD1 KLHL38 KRT20 KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE3C LCE3E LCE4A LINC00656 LOC153684 LRCH4 LUZP4 LYVE1 MAPKBP1 MATN3 MEOX2 MLLT6 MTA1 MXI1 NAB2 NOTCH2NL NUFIP2 OTX1 P2RX7 PCED1A PCSK5 PDE9A PGLS PIGS PKD2 POM121L8P PRKAB2 PRPF31 PRR13 PTGER3 PTPMT1 PTPRH PVR PVRL3 QPRT R3HDM2 RANBP3 RPS28 RTN4RL1 SCNM1 SLC22A23 SLC23A1 SLC25A10 SLC6A20 SMCP SMOC1 SPATA3 SPRY1 SPRY2 STK16 SUSD6 TBC1D16 TBC1D23 THAP10 THAP7 TMEM150A TNIP3 TNP2 TNS2 TRPV6 TXNDC5 TYMSOS TYRO3 UTP23 UXT VPS11 WIF1 WT1 WT1-AS YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF138 ZNF20 ZNF32 ZNF417 ZNF439 ZNF473 ZNF572 ZNF578 ZNF587 ZNF697 ZSCAN21	15 interactors: ACTN2 CD2AP DIAPH1 HAX1 KRT40 KRTAP10-3 KRTAP10-8 MAGEA8 PACS1 PACS2 PKD1 PLSCR1 TNNI3 TPM1 TRPC1
Entrez ID		386681	5311
HPRD ID		11194	01437
Ensembl ID		ENSG00000187766	ENSG00000118762
Uniprot IDs		P60410	Q13563 Q9UEU6
PDB IDs			2KLD 2KLE 2KQ6 2Y4Q 3HRN 3HRO
Enriched GO Terms of Interacting Partners?		Keratinization RNA Biosynthetic Process Transcription, DNA-templated Gene Expression RNA Metabolic Process Pattern Specification Process Keratinocyte Differentiation Organ Development Epithelium Development Cellular Nitrogen Compound Metabolic Process Developmental Process Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Aromatic Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Epidermis Development Tissue Development Negative Regulation Of Glomerulus Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Epidermal Cell Differentiation Macromolecule Biosynthetic Process Metanephric Mesenchyme Development Heterocycle Metabolic Process Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Sperm Motility Negative Regulation Of Cell Proliferation Involved In Kidney Development Fertilization Biosynthetic Process Anterior/posterior Pattern Specification Anatomical Structure Development Epithelial Cell Differentiation Regulation Of Neurotrophin TRK Receptor Signaling Pathway Metanephric S-shaped Body Morphogenesis Single Fertilization System Development Branching Morphogenesis Of An Epithelial Tube Regulation Of Glomerular Mesangial Cell Proliferation Penetration Of Zona Pellucida S-shaped Body Morphogenesis Positive Regulation Of Immune Response To Tumor Cell Floor Plate Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Tube Development Skin Development Bud Elongation Involved In Lung Branching Morphogenesis Of A Branching Epithelium Negative Regulation Of Mesenchymal Cell Apoptotic Process Epithelial Tube Branching Involved In Lung Morphogenesis Morphogenesis Of A Branching Structure	Actin-myosin Filament Sliding Muscle Filament Sliding Regulation Of ATPase Activity Actin-mediated Cell Contraction Actin Filament-based Movement Regulation Of Cellular Localization Endomembrane System Organization Regulation Of Intracellular Transport Regulation Of Cytoskeleton Organization Positive Regulation Of ATPase Activity Cell Projection Organization Muscle Contraction Plasma Membrane Organization Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Actin Filament-based Process Ventricular Cardiac Muscle Tissue Morphogenesis Muscle System Process Cardiac Muscle Contraction Ventricular Cardiac Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Muscle Tissue Morphogenesis Heart Contraction Regulation Of Protein Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Movement Of Cell Or Subcellular Component Metanephric Distal Tubule Morphogenesis Positive Regulation Of Heart Rate By Epinephrine Muscle Organ Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Calcium Ion Transport Into Cytosol Establishment Of Protein Localization To Plasma Membrane Striated Muscle Contraction Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Protein Kinase D Signaling Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Regulation Of Systemic Arterial Blood Pressure Cellular Cation Homeostasis Regulation Of Peptidyl-serine Phosphorylation Cellular Ion Homeostasis Cardiac Ventricle Development Metal Ion Homeostasis Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Tagcloud ?			acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd1 polycystic polycystin progressive severity
Tagcloud (Difference) ?			acts adpkd autosomal chaperone coil coiled complexing determinant disrupted distal glycoform gps heterozygotes illustrating inherited interbreeding maturation mature missense nephropathy nonequimolar pathogenic pc1 pc2 pkd1 polycystic polycystin progressive severity
Tagcloud (Intersection) ?